1. Dutch Prospective Observational Study on Prehospital Treatment of Severe Traumatic Brain Injury: The BRAIN-PROTECT Study Protocol
- Author
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Bossers, SM, Boer, C, Greuters, S, Bloemers, FW, den Hartog, Dennis, Van Lieshout, Esther M.M., Hoogerwerf, N, Innemee, G, van der Naalt, J, Absalom, AR, Peerdeman, SM, Visser, M, Loer, S, Schober, P, Boer, D, Goslings, JC, van Helden, SH, Hesselink, DA, van Aken, G, Beishuizen, A, Egberink, RE, ter Bogt, N, de Jongh, MAC, Lansink, K, Roks, G, Joosse, P, Ponsen, KJ, van Spengler, LL, Aspers, S, de Leeuw, MA, Schwarte, LA, Toor, A, Houmes, RJM, Ditshuizen, Jan, van Voorden, Tea, Edwards, MJR, Dercksen, B, Spanjersberg, R, Venema, L, Weelink, E, Reininga, HF, Surgery, Emergency Medicine, Anesthesiology, IOO, ACS - Diabetes & metabolism, ACS - Microcirculation, APH - Quality of Care, Amsterdam Movement Sciences - Restoration and Development, Other Research, Neurosurgery, AII - Inflammatory diseases, APH - Methodology, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), and Molecular Neuroscience and Ageing Research (MOLAR)
- Subjects
Adult ,Male ,medicine.medical_specialty ,Emergency Medical Services ,Adolescent ,Traumatic brain injury ,Psychological intervention ,030204 cardiovascular system & hematology ,Emergency Nursing ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Clinical Protocols ,Trauma Centers ,Epidemiology ,Brain Injuries, Traumatic ,Emergency medical services ,Medicine ,Humans ,Glasgow Coma Scale ,Prospective Studies ,Registries ,Child ,Aged ,Netherlands ,Aged, 80 and over ,business.industry ,Mortality rate ,Head injury ,Infant ,030208 emergency & critical care medicine ,Middle Aged ,medicine.disease ,Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] ,Child, Preschool ,Emergency medicine ,Emergency Medicine ,Observational study ,Female ,business - Abstract
Contains fulltext : 215205.pdf (Publisher’s version ) (Open Access) Background: Severe traumatic brain injury (TBI) is associated with a high mortality rate and those that survive commonly have permanent disability. While there is a broad consensus that appropriate prehospital treatment is crucial for a favorable neurological outcome, evidence to support currently applied treatment strategies is scarce. In particular, the relationship between prehospital treatments and patient outcomes is unclear. The BRAIN-PROTECT study therefore aims to identify prehospital treatment strategies associated with beneficial or detrimental outcomes. Here, we present the study protocol. Study Protocol: BRAIN-PROTECT is the acronym for BRAin INjury: Prehospital Registry of Outcome, Treatments and Epidemiology of Cerebral Trauma. It is a prospective observational study on the prehospital treatment of patients with suspected severe TBI in the Netherlands. Prehospital epidemiology, interventions, medication strategies, and nonmedical factors that may affect outcome are studied. Multivariable regression based modeling will be used to identify confounder-adjusted relationships between these factors and patient outcomes, including mortality at 30 days (primary outcome) or mortality and functional neurological outcome at 1 year (secondary outcomes). Patients in whom severe TBI is suspected during prehospital treatment (Glasgow Coma Scale score
- Published
- 2019
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