1. Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir
- Author
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Monini, P, Sgadari, C, Grosso, M, Bellino, S, Di Biagio, A, Toschi, E, Bacigalupo, I, Sabbatucci, M, Cencioni, G, Salvi, E, Leone, P, Ensoli, B, Barillari, G, Moracci, G, Carratelli, L, Gatti, G, Brambilla, L, Brambati, M, Ferrucci, S, De Pita, O, Pilla, M, Di Carlo, A, Giuliani, M, Cottoni, F, Cuccuru, M, Calvieri, S, Clerico, R, Potenza, C, Tirelli, U, Simonelli, C, Martellotta, F, Strumia, R, Borghi, A, Del Giacco, S, Moi, L, Piludu, G, Sirianni, M, Campagna, M, Sarmati, L, Andreoni, M, Bianchini, G, Sheldon, J, Milzer, J, and Schulz, T
- Subjects
Aged ,Aged, 80 and over ,Antibodies, Viral ,Antineoplastic Agents ,Biomarkers, Tumor ,HIV Protease Inhibitors ,HIV Seronegativity ,Herpesvirus 8, Human ,Humans ,Indinavir ,Middle Aged ,Sarcoma, Kaposi ,Treatment Outcome ,Settore MED/09 - Medicina Interna ,Settore MED/17 - Malattie Infettive ,Immunology ,Kaposi ,Biology ,Virus ,Antibodies ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,80 and over ,Immunology and Allergy ,HIV Protease Inhibitor ,Protease inhibitor (pharmacology) ,Viral ,Herpesvirus 8 ,Kaposi's sarcoma ,Tumor ,virus diseases ,Sarcoma ,Settore MED/07 - Microbiologia e Microbiologia Clinica ,medicine.disease ,biology.organism_classification ,Infectious Diseases ,Lentivirus ,Biomarkers ,medicine.drug ,Human - Abstract
HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.
- Published
- 2009