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1. 2018 Annual Report of the European Liver Transplant Registry (ELTR) - 50-year evolution of liver transplantation

Author

Adam, René, Karam, Vincent, Cailliez, Valérie, O Grady, John G, Mirza, Darius, Cherqui, Daniel, Klempnauer, Jurgen, Salizzoni, Mauro, Pratschke, Johann, Jamieson, Neville, Hidalgo, Ernest, Paul, Andreas, Andujar, Rafael Lopez, Lerut, Jan, Fisher, Lutz, Boudjema, Karim, Fondevila, Constantino, Soubrane, Olivier, Bachellier, Philippe, Pinna, Antonio D, Berlakovich, Gabriela, Bennet, William, Pinzani, Massimo, Schemmer, Peter, Zieniewicz, Krzysztof, Romero, Carlos Jimenez, De Simone, Paolo, Ericzon, Bo-Goran, Schneeberger, Stefan, Wigmore, Stephen J, Prous, Joan Fabregat, Colledan, Michele, Porte, Robert J, Yilmaz, Sezai, Azoulay, Daniel, Pirenne, Jacques, Line, Pal-Dag, Trunecka, Pavel, Navarro, Francis, Lopez, Andres Valdivieso, De Carlis, Luciano, Pena, Sebastian Rufian, Kochs, Eberhard, Duvoux, Christophe, all the other 126 contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA), Hôpital Paul Brousse, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse, Modèles de Cellules Souches Malignes et Thérapeutiques, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Strasbourg, Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Groningen Institute for Organ Transplantation (GIOT), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Adam, R, Karam, V, Cailliez, V, O Grady, J, Mirza, D, Cherqui, D, Klempnauer, J, Salizzoni, M, Pratschke, J, Jamieson, N, Hidalgo, E, Paul, A, Andujar, R, Lerut, J, Fisher, L, Boudjema, K, Fondevila, C, Soubrane, O, Bachellier, P, Pinna, A, Berlakovich, G, Bennet, W, Pinzani, M, Schemmer, P, Zieniewicz, K, Romero, C, De Simone, P, Ericzon, B, Schneeberger, S, Wigmore, S, Prous, J, Colledan, M, Porte, R, Yilmaz, S, Azoulay, D, Pirenne, J, Line, P, Trunecka, P, Navarro, F, Lopez, A, De Carlis, L, Pena, S, Kochs, E, Duvoux, C, Hôpital Paul Brousse-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon, and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)

Subjects
Male, Registry study, medicine.medical_treatment, Medizin, Disease, 030230 surgery, Liver transplantation, registry, Single Center, DISEASE, Hemangioendothelioma, Outcome, Registry, 0302 clinical medicine, Surveys and Questionnaires, HEPATOCELLULAR-CARCINOMA, Epidemiology, Prospective Studies, Registries, Child, Geography, liver transplantation, Liver Diseases, liver transplantation, outcome, registry, Graft Survival, Liver Neoplasms, Annual report, Middle Aged, Tissue Donors, 3. Good health, Europe, Hepatocellular carcinoma, SURVIVAL, outcome, 030211 gastroenterology & hepatology, Female, Adult, Reoperation, medicine.medical_specialty, Adolescent, PLACE, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Time-to-Treatment, 03 medical and health sciences, Young Adult, QUALITY-CONTROL, medicine, Humans, Aged, Transplantation, business.industry, General surgery, MORTALITY, GRAFT, medicine.disease, HEMANGIOENDOTHELIOMA, CENTERS, EXPERIENCE, business
Abstract

The purpose of this registry study was to provide an overview of trends and results of liver transplantation (LT) in Europe from 1968 to 2016. These data on LT were collected prospectively from 169 centers from 32 countries, in the European Liver Transplant Registry (ELTR) beginning in 1968. This overview provides epidemiological data, as well as information on evolution of techniques, and outcomes in LT in Europe over more than five decades; something that cannot be obtained from only a single center experience. ispartof: TRANSPLANT INTERNATIONAL vol:31 issue:12 pages:1293-1317 ispartof: location:Switzerland status: published

Published
2018
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2. Renal function and cardiopulmonary bypass: Effect of perfusion pressure

Author

Guillermo Bugedo, Andres Valdivieso, Guillermo Lema, Roberto Canessa, Sergio Moran, Sergio Troncoso, Manuel Irarrazaval, Jorge Urzua, Gladys Meneses, and Hernán Muñoz

Subjects
Hemodynamics, Renal function, Blood Pressure, Kidney, law.invention, Phenylephrine, Random Allocation, chemistry.chemical_compound, law, Cardiopulmonary bypass, medicine, Humans, Prospective Studies, Cardiac Surgical Procedures, Aged, Creatinine, Cardiopulmonary Bypass, business.industry, Osmolar Concentration, Sodium, Extracorporeal circulation, Middle Aged, Stimulation, Chemical, Anesthesiology and Pain Medicine, Blood pressure, chemistry, Anesthesia, Potassium, Cardiology and Cardiovascular Medicine, business, Perfusion, medicine.drug
Abstract

Controversy continues as to whether hypotension during cardiopulmonary bypass (CPB) impairs intraoperative and postoperative renal function. Therefore, 21 patients with normal renal function (plasma creatinine less than 1.2 mg/dL, creatinine clearance greater than 70 mL/min), aged 50 to 70 years, without associated pathology, scheduled for elective coronary surgery were studied prospectively. Patients were randomized into two groups: group 1 included 14 patients whose arterial blood pressure during CPB was left untreated, and group 2 consisted of 7 patients who received phenylephrine to maintain their arterial pressure above 70 mmHg. Plasma and urine creatinine, sodium, potassium, and osmolality were measured preoperatively, intraoperatively and postoperatively. Creatinine, osmolal and free water clearances, and excreted sodium fraction were calculated. Plasma creatinine remained normal throughout the study in all patients. Creatinine clearances were similar preoperatively (101.9 +/- 36.7 in group 1 and 120.6 +/- 50.7 mL/min in group 2). In group 1, creatinine clearance decreased during CPB to 88.7 +/- 39.7 mL/min, whereas in group 2 it increased to 157.6 +/- 79.5 mL/min; the difference between groups was significant. Early postoperatively, there was no difference: 136.2 +/- 86.6 mL/min in group 1 and 100 +/- 21.4 mL/min in group 2. One week postoperatively, values were 100.5 +/- 37.9 and 101.9 +/- 18.4, respectively. There was a significant correlation between the creatinine clearance and perfusion pressure intraoperatively, but not postoperatively. Osmolal clearance also correlated with perfusion pressure intraoperatively, but it was significantly lower in the phenylephrine group postoperatively. Postoperative renal function was normal in all patients; no deleterious effect of a low arterial pressure during bypass could be identified.

Published
1992
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