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1. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study

Author

Yoshihiro Kokubo, Isao Saito, Hiroyasu Iso, Kazumasa Yamagishi, Hiroshi Yatsuya, Junko Ishihara, Koutatsu Maruyama, Manami Inoue, Norie Sawada, Shoichiro Tsugane, S. Tsugane, N. Sawada, M. Iwasaki, S. Sasazuki, T. Yamaji, T. Shimazu, T. Hanaoka, J. Ogata, S. Baba, T. Mannami, A. Okayama, Y. Kokubo, K. Miyakawa, F. Saito, A. Koizumi, Y. Sano, I. Hashimoto, T. Ikuta, Y. Tanaba, H. Sato, Y. Roppongi, T. Takashima, H. Suzuki, Y. Miyajima, N. Suzuki, S. Nagasawa, Y. Furusugi, N. Nagai, Y. Ito, S. Komatsu, T. Minamizono, H. Sanada, Y. Hatayama, F. Kobayashi, H. Uchino, Y. Shirai, T. Kondo, R. Sasaki, Y. Watanabe, Y. Miyagawa, Y. Kobayashi, M. Machida, K. Kobayashi, M. Tsukada, Y. Kishimoto, E. Takara, T. Fukuyama, M. Kinjo, M. Irei, H. Sakiyama, K. Imoto, H. Yazawa, T. Seo, A. Seiko, F. Ito, F. Shoji, R. Saito, A. Murata, K. Minato, K. Motegi, T. Fujieda, S. Yamato, K. Matsui, T. Abe, M. Katagiri, M. Suzuki, M. Doi, A. Terao, Y. Ishikawa, T. Tagami, H. Sueta, H. Doi, M. Urata, N. Okamoto, F. Ide, H. Goto, R. Fujita, N. Onga, H. Takaesu, M. Uehara, T. Nakasone, M. Yamakawa, F. Horii, I. Asano, H. Yamaguchi, K. Aoki, S. Maruyama, M. Ichii, M. Takano, Y. Tsubono, K. Suzuki, Y. Honda, K. Yamagishi, S. Sakurai, N. Tsuchiya, M. Kabuto, M. Yamaguchi, Y. Matsumura, S. Sasaki, S. Watanabe, M. Akabane, T. Kadowaki, M. Inoue, M. Noda, T. Mizoue, Y. Kawaguchi, Y. Takashima, Y. Yoshida, K. Nakamura, R. Takachi, J. Ishihara, S. Matsushima, S. Natsukawa, H. Shimizu, H. Sugimura, S. Tominaga, N. Hamajima, H. Iso, T. Sobue, M. Iida, W. Ajiki, A. Ioka, S. Sato, E. Maruyama, M. Konishi, K. Okada, I. Saito, N. Yasuda, S. Kono, S. Akiba, and T. Isobe

Subjects
Male, medicine.medical_specialty, Coronary Disease, Disease, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Dietary Magnesium, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Japan, Risk Factors, Surveys and Questionnaires, Internal medicine, Humans, Medicine, Magnesium, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Stroke, Aged, Nutrition and Dietetics, business.industry, Hazard ratio, Middle Aged, medicine.disease, Diet Records, Coronary heart disease, Confidence interval, Diet, Physical therapy, Population study, Female, business
Abstract

Summary Background & aims The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

Published
2018
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2. Dietary patterns and colorectal cancer risk in middle-aged adults: A large population-based prospective cohort study

Author

M. Ichii, S. Sakurai, Yoshihiro Kokubo, Y. Tsubono, N. Suzuki, H. Goto, T. Kondo, Y. Sato, Takashi Fujieda, Hiroyasu Iso, K. Aoki, M. Doi, T. Isobe, M. Kinjo, Kouji Minato, Norie Sawada, K. Imoto, H. Suzuki, E. Takara, Y. Watanabe, S. Tominaga, R. Sasaki, S. Sato, T. Abe, Y. Ito, Y. Roppongi, T. Tagami, Y. Kishimoto, M. Iwasaki, Y. Miyajima, K. Nakamura, T. Seo, S. Komatsu, Minoru Iida, S. Matsushima, Taiki Yamaji, J. Ogata, A. Seiko, N. Okamoto, M. Uehara, K. Matsui, H. Yazawa, H. Sueta, Kazumasa Yamagishi, S. Akiba, H. Yamaguchi, T. Shimazu, S. Kono, Y. Shirai, I. Asano, Y. Tanaba, N. Tsuchiya, H. Sugimura, Y. Hatayama, S. Tsugane, I. Hashimoto, N. Nagai, Y. Matsumura, K. Miyakawa, A. Okayama, Akiko Nanri, A. Terao, T. Minamizono, K. Suzuki, M. Urata, S. Natsukawa, T. Fukuyama, Tetsuya Mizoue, Shoichiro Tsugane, J. Ishihara, Nobuyuki Hamajima, Y. Honda, M. Katagiri, Y. Yoshida, M. Inoue, H. Sato, Ribeka Takachi, K. Kobayashi, R. Saito, Sangah Shin, M. Irei, R. Takachi, Y. Ishikawa, Y. Kawaguchi, Tomotaka Sobue, Eiko Saito, S. Nagasawa, Mitsuhiko Noda, Taichi Shimazu, T. Nakasone, M. Kabuto, Nobufumi Yasuda, Isao Saito, K. Okada, Yukiaki Miyagawa, M. Akabane, F. Kobayashi, T. Hanaoka, S. Sasaki, M. Suzuki, A. Ioka, F. Ide, F. Shoji, Y. Kobayashi, S. Sasazuki, Hiroshi Sakiyama, M. Yamakawa, K. Motegi, H. Shimizu, S. Yamato, Shizuka Sasazuki, A. Murata, Junko Ishihara, F. Ito, M. Tsukada, Toshifumi Mannami, S. Baba, F. Horii, Motoki Iwasaki, H. Uchino, W. Ajiki, Takashi Kadowaki, T. Takashima, Y. Furusugi, N. Onga, Masamitsu Konishi, S. Watanabe, A. Koizumi, T. Ikuta, M. Takano, H. Doi, S. Maruyama, Yasuhiro Takashima, Y. Sano, H. Sanada, M. Yamaguchi, E. Maruyama, M. Machida, R. Fujita, H. Takaesu, F. Saito, and Manami Inoue

Subjects
Adult, Male, Gerontology, medicine.medical_specialty, Colorectal cancer, Critical Care and Intensive Care Medicine, Diet Surveys, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Japan, Risk Factors, Surveys and Questionnaires, Epidemiology, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Aged, Nutrition and Dietetics, business.industry, Public health, Confounding, Cancer, Middle Aged, Dietary pattern, medicine.disease, Diet, 030220 oncology & carcinogenesis, Cohort, Female, Colorectal Neoplasms, business, Demography
Abstract

A finding between dietary pattern and cancer may provide visions beyond the assessment of individual foods or nutrients. We examined the influence of dietary pattern with colorectal cancer (CRC) among a Japanese population.A total of 93,062 subjects (43,591 men, 49,471 women) who participated in the Japan Public Health Center-based Prospective Study were followed from 1995-1998 to the end of 2012, during which 2482 cases of CRC (1514 men, 968 women) were newly identified. Dietary data was obtained from a validated food-frequency questionnaire between 1995 and 1998.Three dietary pattern was derived from principal components factor: prudent, westernized, and traditional pattern. After controlled for potential confounders, the prudent pattern showed a decreased association of CRC risk in men (HR for highest quintile vs lowest: 0.85; 95% CI: 0.72-1.00; P trend0.05), slightly more strongly with distal colon cancer (P trend0.05); but an increased risk of rectal cancer in women (P trend0.05). The westernized pattern showed a significant positive linear trend for colon (P trend0.05) and distal cancer (P trend0.05) in women. There was no apparent association of traditional Japanese dietary pattern on the overall or any specific sites risk of CRC.A prudent dietary pattern showed an inverse association with CRC risk in men, and a westernized pattern was related with a higher risk of colon and distal cancer in women.

Published
2018
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3. Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective Study

Author

Thomas, Svensson, Manami, Inoue, Norie, Sawada, Kazumasa, Yamagishi, Hadrien, Charvat, Isao, Saito, Yoshihiro, Kokubo, Hiroyasu, Iso, Noriyuki, Kawamura, Kenji, Shibuya, Masaru, Mimura, Shoichiro, Tsugane, S, Tsugane, N, Sawada, M, Iwasaki, S, Sasazuki, T, Shimazu, T, Yamaji, T, Hanaoka, J, Ogata, S, Baba, T, Mannami, A, Okayama, Y, Kokubo, K, Miyakawa, F, Saito, A, Koizumi, Y, Sano, I, Hashimoto, T, Ikuta, Y, Tanaba, H, Sato, Y, Roppongi, T, Takashima, Y, Miyajima, N, Suzuki, S, Nagasawa, Y, Furusugi, N, Nagai, Y, Ito, S, Komatsu, T, Minamizono, H, Sanada, Y, Hatayama, F, Kobayashi, H, Uchino, Y, Shirai, T, Kondo, R, Sasaki, Y, Watanabe, Y, Miyagawa, Y, Kobayashi, M, Machida, K, Kobayashi, M, Tsukada, Y, Kishimoto, E, Takara, T, Fukuyama, M, Kinjo, M, Irei, H, Sakiyama, K, Imoto, H, Yazawa, T, Seo, A, Seiko, F, Ito, F, Shoji, R, Saito, A, Murata, K, Minato, K, Motegi, T, Fujieda, S, Yamato, K, Matsui, T, Abe, M, Katagiri, M, Suzuki, M, Doi, A, Terao, Y, Ishikawa, T, Tagami, H, Sueta, H, Doi, M, Urata, N, Okamoto, F, Ide, H, Goto, N, Onga, H, Takaesu, M, Uehara, T, Nakasone, M, Yamakawa, F, Horii, I, Asano, H, Yamaguchi, K, Aoki, S, Maruyama, M, Ichii, M, Takano, Y, Tsubono, K, Suzuki, Y, Honda, K, Yamagishi, S, Sakurai, N, Tsuchiya, M, Kabuto, M, Yamaguchi, Y, Matsumura, S, Sasaki, S, Watanabe, M, Akabane, T, Kadowaki, M, Inoue, M, Noda, T, Mizoue, Y, Kawaguchi, Y, Takashima, Y, Yoshida, K, Nakamura, R, Takachi, J, Ishihara, S, Matsushima, S, Natsukawa, H, Shimizu, H, Sugimura, S, Tominaga, N, Hamajima, H, Iso, T, Sobue, M, Iida, W, Ajiki, A, Ioka, S, Sato, E, Maruyama, M, Konishi, K, Okada, I, Saito, N, Yasuda, S, Kono, and S, Akiba

Subjects
Male, Coping (psychology), medicine.medical_specialty, Myocardial Infarction, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Japan, Risk Factors, Internal medicine, Adaptation, Psychological, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Stroke, Aged, Proportional hazards model, business.industry, Incidence, Incidence (epidemiology), Hazard ratio, Avoidance coping, Middle Aged, medicine.disease, Cardiovascular Diseases, Cohort, Physical therapy, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Coping strategies may be significantly associated with health outcomes. This is the first study to investigate the association between baseline coping strategies and cardiovascular disease (CVD) incidence and mortality in a general population cohort. Methods and results The Japan Public Health Center-based prospective Study asked questions on coping in its third follow-up survey (2000–04). Analyses on CVD incidence and mortality included 57 017 subjects aged 50–79 without a history of CVD and who provided complete answers on approach- and avoidance-oriented coping behaviours and strategies. Cox regression models, adjusted for confounders, were used to determine hazard ratios (HRs) according to coping style. Mean follow-up time was 7.9 years for incidence and 8.0 years for mortality. The premorbid use of an approach-oriented coping strategy was inversely associated with incidence of stroke (HR = 0.85; 95% CI, 0.73–1.00) and CVD mortality (HR = 0.74; 95% CI, 0.55–0.99). Stroke subtype analyses revealed an inverse association between the approach-oriented coping strategy and incidence of ischaemic stroke (HR = 0.79; 95% CI, 0.64–0.98) and a positive association between the combined coping strategy and incidence of intra-parenchymal haemorrhage (HR = 2.03; 95% CI, 1.01–4.10). Utilizing an avoidance coping strategy was associated with increased mortality from ischaemic heart disease (IHD) only in hypertensive individuals (HR = 3.46; 95% CI, 1.07–11.18). The coping behaviours fantasizing and positive reappraisal were associated with increased risk of CVD incidence (HR = 1.24; 95% CI, 1.03–1.50) and reduced risk of IHD mortality (HR = 0.63; 95% CI, 0.40–0.99), respectively. Conclusion An approach-oriented coping strategy, i.e. proactively dealing with sources of stress, may be associated with significantly reduced stroke incidence and CVD mortality in a Japanese population-based cohort.

Published
2016
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4. Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study

Author

Kei Hamazaki, Hiroyasu Iso, Ehab S. Eshak, Satoyo Ikehara, Ai Ikeda, Motoki Iwasaki, Tomohito Hamazaki, Shoichiro Tsugane, S. Tsugane, N. Sawada, M. Iwasaki, S. Sasazuki, T. Yamaji, T. Shimazu, A. Goto, A. Hidaka, T. Hanaoka, J. Ogata, S. Baba, T. Mannami, A. Okayama, Y. Kokubo, K. Miyakawa, F. Saito, A. Koizumi, Y. Sano, I. Hashimoto, T. Ikuta, Y. Tanaba, H. Sato, Y. Roppongi, T. Takashima, H. Suzuki, Y. Miyajima, N. Suzuki, S. Nagasawa, Y. Furusugi, N. Nagai, Y. Ito, S. Komatsu, T. Minamizono, H. Sanada, Y. Hatayama, F. Kobayashi, H. Uchino, Y. Shirai, T. Kondo, R. Sasaki, Y. Watanabe, Y. Miyagawa, Y. Kobayashi, M. Machida, K. Kobayashi, M. Tsukada, Y. Kishimoto, E. Takara, T. Fukuyama, M. Kinjo, M. Irei, H. Sakiyama, K. Imoto, H. Yazawa, T. Seo, A. Seiko, F. Ito, F. Shoji, R. Saito, A. Murata, K. Minato, K. Motegi, T. Fujieda, S. Yamato, M. Doi, K. Matsui, T. Abe, M. Katagiri, M. Suzuki, A. Terao, Y. Ishikawa, T. Tagami, H. Sueta, H. Doi, M. Urata, N. Okamoto, F. Ide, H. Goto, R. Fujita, Y. Sou, N. Onga, H. Takaesu, M. Uehara, T. Nakasone, M. Yamakawa, F. Horii, I. Asano, H. Yamaguchi, K. Aoki, S. Maruyama, M. Ichii, M. Takano, Y. Tsubono, K. Suzuki, Y. Honda, K. Yamagishi, S. Sakurai, N. Tsuchiya, M. Kabuto, M. Yamaguchi, Y. Matsumura, S. Sasaki, S. Watanabe, M. Akabane, T. Kadowaki, M. Inoue, M. Noda, T. Mizoue, Y. Kawaguchi, Y. Takashima, Y. Yoshida, K. Nakamura, R. Takachi, J. Ishihara, S. Matsushima, S. Natsukawa, H. Shimizu, H. Sugimura, S. Tominaga, N. Hamajima, H. Iso, T. Sobue, M. Iida, W. Ajiki, A. Ioka, S. Sato, E. Maruyama, M. Konishi, K. Okada, I. Saito, N. Yasuda, S. Kono, S. Akiba, T. Isobe, and Y. Sato

Subjects
Adult, Male, medicine.medical_specialty, Coronary Disease, 030204 cardiovascular system & hematology, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, Japan, Risk Factors, Internal medicine, Surveys and Questionnaires, Fatty Acids, Omega-3, Fish Products, medicine, Odds Ratio, Humans, 030212 general & internal medicine, Myocardial infarction, Aged, chemistry.chemical_classification, Meal, business.industry, Odds ratio, Feeding Behavior, Middle Aged, medicine.disease, Confidence interval, Death, Sudden, Cardiac, chemistry, Quartile, Case-Control Studies, Cohort, Multivariate Analysis, Female, Public Health, Cardiology and Cardiovascular Medicine, business, Polyunsaturated fatty acid, Follow-Up Studies
Abstract

Background and aims Higher intake of fish or n-3 polyunsaturated fatty acids (PUFAs) has been associated with reduced risk of coronary heart disease (CHD). However, it is unclear whether increased blood levels of n-3 PUFAs are associated with reduced risk of CHD in the Japanese population. Methods The relationship between circulating levels of n-3 PUFAs (eicosapentaenoic acid + docosapentaenoic acid + docosahexaenoic acid) and risk of CHD was examined in a nested case-control study among participants in the Japan Public Health Center (JPHC)-based Study Cohort. Plasma n-3 PUFA phospholipid levels were measured at baseline by gas chromatography in 209 cases with CHD and 418 controls matched for sex, age, date of blood draw, time elapsed since last meal before blood collection, and study location. The CHD cases (n = 209) comprised 168 cases of myocardial infarction and 41 of sudden cardiac death, otherwise classified as 157 non-fatal and 52 fatal coronary events, respectively. Mean duration of follow-up was 13.5 years. Results Multivariate conditional logistic analysis showed no significant association between n-3 PUFAs and risk of total CHD. The odds ratio (OR) for the highest versus lowest quartiles of plasma n-3 PUFAs was 0.79 (95% confidence interval [95% CI]: 0.41–1.51, p for trend = 0.51). Subtype analysis of CHD revealed that the multivariate ORs for the highest versus lowest quartiles for n-3 PUFAs were 0.91 (95% CI: 0.43–1.89, p for trend = 0.90) for myocardial infarction, 0.08 (95% CI: 0.01–0.88, p for trend = 0.04) for sudden cardiac death, 0.89 (95% CI: 0.42–1.89, p for trend = 0.97) for nonfatal coronary events, and 0.12 (95% CI: 0.02–0.75, p for trend = 0.03) for fatal coronary events. Conclusions Plasma n-3 PUFA levels were not associated with risk of total CHD but were inversely associated with risks of sudden cardiac death and fatal coronary events among middle-aged Japanese individuals.

Published
2017

5. Modification of the Excess Risk of Coronary Heart Disease Due to Smoking by Seafood/Fish Intake

Author

E. S. Eshak, H. Iso, K. Yamagishi, Y. Kokubo, I. Saito, H. Yatsuya, N. Sawada, M. Inoue, S. Tsugane, T. Sobue, T. Hanaoka, J. Ogata, S. Baba, T. Mannami, A. Okayama, K. Miyakawa, F. Saito, A. Koizumi, Y. Sano, I. Hashimoto, T. Ikuta, Y. Miyajima, N. Suzuki, S. Nagasawa, Y. Furusugi, N. Nagai, H. Sanada, Y. Hatayama, F. Kobayashi, H. Uchino, Y. Shirai, T. Kondo, R. Sasaki, Y. Watanabe, Y. Miyagawa, Y. Kobayashi, Y. Kishimoto, E. Takara, T. Fukuyama, M. Kinjo, M. Irei, H. Sakiyama, K. Imoto, H. Yazawa, T. Seo, A. Seiko, F. Ito, F. Shoji, A. Murata, K. Minato, K. Motegi, T. Fujieda, K. Matsui, T. Abe, M. Katagiri, M. Suzuki, M. Doi, A. Terao, Y. Ishikawa, T. Tagami, H. Sueta, H. Doi, M. Urata, N. Okamoto, F. Ide, N. Onga, H. Takaesu, M. Uehara, F. Horii, I. Asano, H. Yamaguchi, K. Aoki, S. Maruyama, M. Ichii, M. Takano, Y. Tsubono, K. Suzuki, Y. Honda, S. Sakurai, M. Kabuto, M. Yamaguchi, Y. Matsumura, S. Sasaki, S. Watanabe, M. Akabane, T. Kadowaki, M. Noda, Y. Kawaguchi, Y. Takashima, K. Nakamura, S. Matsushima, S. Natsukawa, H. Shimizu, H. Sugimura, S. Tominaga, M. Iida, W. Ajiki, A. Ioka, S. Sato, E. Maruyama, M. Konishi, K. Okada, N. Yasuda, and S. Kono

Subjects
Male, medicine.medical_specialty, Time Factors, Epidemiology, Health Behavior, Protective factor, Coronary Disease, Sex Factors, Japan, Internal medicine, Environmental health, Humans, Medicine, Fish intake, Myocardial infarction, Risk factor, Aged, Dose-Response Relationship, Drug, business.industry, Smoking, Hazard ratio, Age Factors, Absolute risk reduction, food and beverages, Middle Aged, medicine.disease, Confidence interval, Coronary heart disease, Diet, Seafood, Cardiovascular Diseases, Cardiology, Female, business
Abstract

Seafood/fish intake has been regarded as a protective factor for coronary heart disease (CHD), while smoking is a strong risk factor. To examine whether associations between smoking and risk of CHD are modified by seafood/fish intake, we studied 72,012 Japanese men and women aged 45-74 years who completed 2 food frequency questionnaires, 5 years apart, during the period 1995-2009. After 878,163 person-years of follow-up, 584 incident cases of CHD (101 fatal and 483 nonfatal), including 516 myocardial infarctions, were documented. There was a clear dose-response association between smoking and CHD risk among subjects with a low seafood/fish intake (

Published
2014
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6. Association of green tea consumption with mortality due to all causes and major causes of death in a Japanese population: the Japan Public Health Center-based Prospective Study (JPHC Study)

Author

Eiko Saito, Manami Inoue, Norie Sawada, Taichi Shimazu, Taiki Yamaji, Motoki Iwasaki, Shizuka Sasazuki, Mitsuhiko Noda, Hiroyasu Iso, Shoichiro Tsugane, S. Tsugane, N. Sawada, M. Iwasaki, S. Sasazuki, T. Yamaji, T. Shimazu, T. Hanaoka, J. Ogata, S. Baba, T. Mannami, A. Okayama, Y. Kokubo, K. Miyakawa, F. Saito, A. Koizumi, Y. Sano, I. Hashimoto, T. Ikuta, Y. Tanaba, H. Sato, Y. Roppongi, T. Takashima, Y. Miyajima, N. Suzuki, S. Nagasawa, Y. Furusugi, N. Nagai, Y. Ito, S. Komatsu, T. Minamizono, H. Sanada, Y. Hatayama, F. Kobayashi, H. Uchino, Y. Shirai, T. Kondo, R. Sasaki, Y. Watanabe, Y. Miyagawa, Y. Kobayashi, M. Machida, K. Kobayashi, M. Tsukada, Y. Kishimoto, E. Takara, T. Fukuyama, M. Kinjo, M. Irei, H. Sakiyama, K. Imoto, H. Yazawa, T. Seo, A. Seiko, F. Ito, F. Shoji, R. Saito, A. Murata, K. Minato, K. Motegi, T. Fujieda, S. Yamato, K. Matsui, T. Abe, M. Katagiri, M. Suzuki, M. Doi, A. Terao, Y. Ishikawa, T. Tagami, H. Sueta, H. Doi, M. Urata, N. Okamoto, F. Ide, H. Goto, N. Onga, H. Takaesu, M. Uehara, T. Nakasone, M. Yamakawa, F. Horii, I. Asano, H. Yamaguchi, K. Aoki, S. Maruyama, M. Ichii, M. Takano, Y. Tsubono, K. Suzuki, Y. Honda, K. Yamagishi, S. Sakurai, N. Tsuchiya, M. Kabuto, M. Yamaguchi, Y. Matsumura, S. Sasaki, S. Watanabe, M. Akabane, T. Kadowaki, M. Inoue, M. Noda, T. Mizoue, Y. Kawaguchi, Y. Takashima, Y. Yoshida, K. Nakamura, R. Takachi, J. Ishihara, S. Matsushima, S. Natsukawa, H. Shimizu, H. Sugimura, S. Tominaga, N. Hamajima, H. Iso, T. Sobue, M. Iida, W. Ajiki, A. Ioka, S. Sato, E. Maruyama, M. Konishi, K. Okada, I. Saito, N. Yasuda, S. Kono, and S. Akiba

Subjects
Gerontology, Adult, Male, medicine.medical_specialty, Epidemiology, Population, Respiratory Tract Diseases, Poison control, Sex Factors, Asian People, Japan, Risk Factors, Environmental health, Cause of Death, Injury prevention, medicine, Humans, Prospective Studies, Mortality, education, Prospective cohort study, Aged, Proportional Hazards Models, education.field_of_study, Tea, Proportional hazards model, business.industry, Public health, Incidence, Hazard ratio, Middle Aged, Cardiovascular Diseases, Female, business, Cohort study
Abstract

We examined the association between green tea consumption and mortality due to all causes, cancer, heart disease, cerebrovascular disease, respiratory disease, injuries, and other causes of death in a large-scale population-based cohort study in Japan.We studied 90,914 Japanese (aged between 40 and 69 years) recruited between 1990 and 1994. After 18.7 years of follow-up, 12,874 deaths were reported. The association between green tea consumption and risk of all causes and major causes of mortality was assessed using the Cox proportional hazards regression model with adjustment for potential confounders.Hazard ratios for all-cause mortality among men who consumed green tea compared with those who drank less than 1 cup/day were 0.96 (0.89-1.03) for 1-2 cups/day, 0.88 (0.82-0.95) for 3-4 cups/day, and 0.87 (0.81-0.94) for more than 5 cups/day (P for trend.001). Corresponding hazard ratios for women were 0.90 (0.81-1.00), 0.87 (0.79-0.96), and 0.83 (0.75-0.91; P for trend.001). Green tea was inversely associated with mortality from heart disease in both men and women and mortality from cerebrovascular disease and respiratory disease in men. No association was found between green tea and total cancer mortality.This prospective study suggests that the consumption of green tea may reduce the risk of all-cause mortality and the three leading causes of death in Japan.

Published
2014

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