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1. The Effect of Tafamidis on Circulating Endothelial Progenitor Cells in Patients with Transthyretin Cardiac Amyloidosis

Author

Osnat, Itzhaki Ben Zadok, Dorit, Leshem-Lev, Tuvia, Ben-Gal, Ashraf, Hamdan, Nili, Schamroth Pravda, Tali, Steinmetz, Irit, Kandinov, Ilit, Ovadia, Ran, Kornowski, and Alon, Eisen

Subjects
Aged, 80 and over, Male, Vascular Endothelial Growth Factor A, Benzoxazoles, Humans, Prealbumin, Female, Amyloidosis, Cardiomyopathies, Vascular Endothelial Growth Factor Receptor-2, Aged, Endothelial Progenitor Cells
Abstract

Endothelial microvascular dysfunction is a known mechanism of vascular pathology in cardiac amyloidosis (CA). Scientific evidence regarding the possible protective role of the amyloid transthyretin (ATTR) stabilizer, tafamidis, is lacking. Circulating endothelial progenitor cells (cEPCs) have an important role in the process of vascular repair. We aimed to examine the effect of tafamidis on cEPCs.Study population included patients with ATTR-CA. cEPCs were assessed using flow cytometry by the expression of CD34Tafamidis induced the activation of the cEPCs pathway, possibly promoting endothelial repair in ATTR-CA.

Published
2021

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