1. Metabolic profiling of serum in patients with cartilage tumours using
- Author
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Liliana, López-Garrido, Angel E, Bañuelos-Hernández, Elizabeth, Pérez-Hernández, Romeo, Tecualt-Gómez, Jorge, Quiroz-Williams, Armando, Ariza-Castolo, Elvia, Becerra-Martínez, and Nury, Pérez-Hernández
- Subjects
Adult ,Male ,Serum ,Magnetic Resonance Spectroscopy ,Chondrosarcoma ,Discriminant Analysis ,Pilot Projects ,Middle Aged ,Molecular Dynamics Simulation ,Cartilage ,Multivariate Analysis ,Biomarkers, Tumor ,Humans ,Metabolomics ,Female ,Chondroma ,Metabolic Networks and Pathways ,Aged ,Neoplasm Staging - Abstract
Cartilage-forming lesions include tumours that can vary in severity from benign enchondromas to high-grade malignant chondrosarcomas. Chondrosarcoma is the second most frequent malignant bone tumour, accounting for 20-30% of all malignant bone neoplasms. Surgery is the standard treatment for cartilage tumours (CTs); however, their incidental diagnosis and the difficult differentiation of low-grade lesions like chondrosarcoma grade I from benign entities like enchondroma are challenges for clinical management. In this sense, the search for circulating biomarkers for early detection and prognosis is an ongoing interest. Targeted metabolomics is a powerful tool that can propose potential biomarkers in biological fluids as well as help to discover disturbed metabolic pathways to reveal tumour pathogenesis. In this context, the aim of this study was to investigate the
- Published
- 2019