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1. [Age-related and clinical-pathogenetic features of colorectal cancer associated with status of K-ras gene].

Author

Beliaeva AV, Ianus GA, Suspithyn EN, Zaĭtseva OA, Iatsuk OS, Moiseenko AB, Guliaev AV, and Imianitov EN

Subjects
Adult, Aged, Aged, 80 and over, Aging pathology, Colonic Neoplasms epidemiology, Colonic Neoplasms pathology, Female, Humans, Male, Middle Aged, Mutation Rate, Polymerase Chain Reaction, Rectal Neoplasms epidemiology, Rectal Neoplasms pathology, Russia, Aging genetics, Colonic Neoplasms genetics, Genes, ras genetics, Mutation, Rectal Neoplasms genetics
Abstract

Activating mutation in K-ras gene is a key event in the pathogenesis of colon carcinoma. This study analyses frequency of this mutation in different age groups of colorectal cancer patients residing in North-Western Russia, and examines its relationship with essential clinical characteristics of tumor disease.

Published
2012

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