1. Muscle loss associated changes of oxylipin signatures during biological aging: an exploratory study from the PROOF cohort
- Author
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Alice Decourt, Cécile Coudy-Gandilhon, Annika I. Ostermann, Thade Konrad, Cécile Gladine, Daniel Béchet, Nils Helge Schebb, Céline Dalle, Léonard Féasson, Frédéric Roche, André Mazur, Jean-Claude Barthélémy, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Faculty of Mathematics and Natural Sciences, University of Wuppertal, University of Veterinary Medicine Hanover, Service de Physiologie Clinique et de l'Exercice, Faculté de Médecine Jacques Lisfranc, PRES Université de Lyon, Université Jean Monnet (Saint-Etienne), Université de Lyon, Service de Neurologie, Centre Hospitalier du Pays d'Aix, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), German Resaerch Foundation SCHE 1801Fondation Caisse d'Epargne Rhone-Alpes (CERA) 30French government IDEX-ISITE initiative 16-IDEX-0001 CAP 20-25French Ministry of Health, ProdInra, Archive Ouverte, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Institute for Food Toxicology, University of Veterinary Medicine, Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, service de chirurgie cardiaque, Centre Hospitalier Universitaire Gabriel Montpied, Service de Physiologie Clinique et de l'Exercice, CHU Nord, Faculté de Médecine Jacques Lisfranc, Unité de Myologie, Centre Référent Maladies Neuromusculaires Rares Rhône-Alpes, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Unité de Myologie, Centre Hospitalier Universitaire de Saint-Etienne, Service de Physiologie Clinique et de l'Exercice [CHU de Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Université Catholique de Louvain (UCLouvain). BEL., CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Institut Multidisciplinaire de Biochimie des Lipides (IMBL). FRA., Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), ANR-16-IDEX-0001,CAP 20-25,CAP 20-25(2016), Unité de Nutrition Humaine - Clermont Auvergne ( UNH ), Université Clermont Auvergne ( UCA ) -Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] ( INRA Auvergne/Rhône-Alpes ), and Centre Hospitalier Universitaire de Saint-Etienne ( CHU de Saint-Etienne )
- Subjects
0301 basic medicine ,Male ,Aging ,Sarcopenia ,[CHIM.ANAL] Chemical Sciences/Analytical chemistry ,[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition ,Lipid mediators ,Inflammation ,medicine.disease_cause ,Bioinformatics ,analyse métabolomique ,03 medical and health sciences ,0302 clinical medicine ,Metabolomics ,Absorptiometry, Photon ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,medicine ,Humans ,Longitudinal Studies ,Oxylipins ,Prospective Studies ,perte de muscle ,Aged, 80 and over ,business.industry ,Lipid signaling ,vieillissement ,Oxylipin ,medicine.disease ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,030104 developmental biology ,oxylipine ,Ageing ,ageing ,Cohort ,Eicosanoids ,Female ,Geriatrics and Gerontology ,medicine.symptom ,business ,étude de cohorte ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,030217 neurology & neurosurgery ,Oxidative stress ,Biomarkers - Abstract
L’Unité de Nutrition Humaine (UNH - Clermont-Ferrand) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème éditionL’Unité de Nutrition Humaine (UNH - Clermont-Ferrand) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème édition; Characterizations of the multiple mechanisms determining biological aging are required tobetter understand the etiology and identify early biomarkers of sarcopenia. Oxylipins are a largefamily of signaling lipids involved in the regulation of various biological processes that becomedysregulated during aging.To investigate whether comprehensive oxylipin profiling could provide an integrated and finecharacterisation of the early phases of sarcopenia, we performed a quantitative targetedmetabolomics of oxylipins in plasma of 81-year old subjects from the PROOF cohort withdecreased (n=12), stable (n=16) or increased appendicular muscle mass (n=14).Multivariate and univariate analyses identified significant and concordant changes of oxylipinprofiles according to the muscle status. Of note, 90% of the most discriminant oxylipins werederived from EPA and DHA and were increased in the sarcopenic subjects. The oxylipinssignatures of sarcopenic subjects revealed subtle activation of inflammatory resolutionpathways, coagulation processes and oxidative stress and the inhibition of angiogenesis. Heatmaps highlighted relationships between oxylipins and the cardiometabolic health parameterswhich were mainly lost in sarcopenic subjects.This exploratory study supports that targeted metabolomics of oxylipins could provide relevantand subtle characterization of early disturbances associated with muscle-loss during aging.
- Published
- 2019