1. Effect of industrial point-source air pollutants on fractional exhaled nitric oxide in healthy volunteers.
- Author
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Cakmak S, Kauri L, Mahmud M, Shutt R, Liu L, Rigden M, Kumarathasan P, Vincent R, Thomson EM, and Dales R
- Subjects
- Adult, Cross-Over Studies, Healthy Volunteers, Humans, Particulate Matter, Young Adult, Air Pollutants, Air Pollution, Environmental Exposure, Nitric Oxide
- Abstract
Background: Few studies have examined the effects of industrial, fixed-site sources of air pollution on lung inflammation in nearby residents. We investigated the effects of short-term exposure to ambient air near a steel plant on the fractional exhaled concentration of nitric oxide (FeNO), a measure of airway inflammation, in healthy volunteers., Methods: A cross-over study design was used. Fifty-nine non-smoking participants (mean age 24 years) were randomly assigned to each of two 5-day exposure scenarios: breathing ambient air adjacent to a steel plant or 5 km away at a college campus site. FeNO and on-site air pollutants were measured daily. Mixed effects linear regression models were used for data analysis, adjusting for sex, temperature, humidity and day of week., Results: Compared with the college site, PM
2.5 , ultrafine PM, SO2 , NO2 and CO levels were significantly greater near the steel plant. FeNO was 15.3% (95% CI, 6.6%, 24.8%) higher near the plant compared to the college site., Conclusions: Exposure to ambient air near a steel plant was associated with increased airway inflammation as measured by exhaled nitric oxide., (Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.)- Published
- 2020
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