1. Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation
- Author
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Tan, Yu-Rong, Qi, Ming-Ming, Qin, Xiao-Qun, Xiang, Yang, Li, Xiang, Wang, Yue, Qu, Fei, Liu, Hui-Jun, and Zhang, Jian-Song
- Subjects
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AIRWAY (Anatomy) , *BRONCHI , *EPITHELIAL cells , *ANTISENSE nucleic acids - Abstract
Abstract: The present study was designed to investigate the role of bombesin receptor subtype 3 (BRS-3) in airway wound repair. The results showed that: (1) There was few expression of BRS-3 mRNA in the control group. In contrast, the expression of BRS-3 mRNA was gradually increased in the early 2 days, and peaked on the fourth day, and then decreased in the ozone-stressed AHR animal. BRS-3 mRNA was distributed in the ciliated columnar epithelium, monolayer columnar epithelium cells, scattered mesenchymal cells and Type II alveolar cells; (2) The wound repair and proliferation of bronchial epithelial cells (BECs) were accelerated in a concentration-dependent manner by BRS-3 activation with P3513, which could be inhibited by PKA inhibitor H89. The study demostrated that activation of BRS-3 may play an important role in wound repair of AHR. [Copyright &y& Elsevier]
- Published
- 2006
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