1. Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass
- Author
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Daria, Starybrat, Rosanne, Jepson, Poppy, Bristow, Sarah, Peterson, Maha, Yerramilli, Murthy, Yerramilli, Yu-Mei, Chang, and Stefano, Cortellini
- Subjects
Cardiopulmonary Bypass ,General Veterinary ,clusterin ,creatinine ,CPB ,inosine ,Acute Kidney Injury ,Inosine ,BAIB ,Dogs ,C-Reactive Protein ,AKI ,Predictive Value of Tests ,cystatin B ,Creatinine ,SDMA ,Animals ,Prospective Studies ,Dog Diseases ,Cardiac Surgical Procedures ,CRP ,Biomarkers - Abstract
Objective: To assess the occurrence of acute kidney injury (AKI) in dogs undergoing cardiac surgery under cardiopulmonary bypass (CPB) and explore associations between traditional and novel serum and urinary biomarkers. Design: Prospective cohort study conducted between July 2018 and April 2019. Setting: University teaching hospital. Animals: Nineteen dogs undergoing cardiac surgery under CPB with preoperative serum creatinine 1, T 2, T 3, and T 4). AKI was defined as an increase in serum creatinine ≥26.4 μmol/L (≥0.3 mg/dl) above baseline within 48 hours. Serum creatinine, C-reactive protein (CRP), symmetric dimethylarginine (SDMA), inosine, beta-aminoisobutyric acid (BAIB), urinary clusterin (uClus), and urinary cystatin B (uCysB) were measured. Data were log-transformed (log 10) when appropriate and assessed using linear mixed-effects models. Measurements and Main Results: AKI occurred in 3 of 19 dogs (15.8%, 95% confidence interval: 0.047–0.384). Inosine increased at T 2 (adjusted mean ± standard error: 53 ± 5.6) in all dogs, and then gradually decreased. Log 10uCysB increased at T 2 (2.3 ± 0.1) in all dogs and remained high. Log 10CRP and log 10uClus increased significantly at T 3 (1.9 ± 0.1 and 3.6 ± 0.1, respectively) in all dogs and remained increased. There was a significant positive association between serum creatinine and SDMA (P 10CRP and log 10uClus (P
- Published
- 2022
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