1. Review: Roles of human serum albumin in prediction, diagnoses and treatment of COVID-19
- Author
-
Sae-Young Ahn and Gulam Rabbani
- Subjects
HMA, human mercaptalbumin ,Serum Albumin, Human ,Disease ,Review ,Biochemistry ,ACE2, angiotensin-converting-enzyme 2 ,ROS, reactive oxygen species ,Structural Biology ,SARSCoV-2, severe acute respiratory syndrome coronavirus 2 ,Diabetes mellitus ,ACE, angiotensin (Ang)-converting enzyme ,DM, diabetes mellitus ,Coagulopathy ,medicine ,Humans ,Hypoalbuminemia ,Vascular Diseases ,Molecular Biology ,ARDS, acute respiratory distress syndrome ,ARB, angiotensin receptor blockers ,COVID-19, coronavirus disease 2019 ,Vascular disease ,business.industry ,SARS-CoV-2 ,Diabetes ,Albumin ,COVID-19 ,Human serum albumin ,General Medicine ,Blood Coagulation Disorders ,medicine.disease ,Blood proteins ,CVD, cardiovascular diseases ,HNA, human non-mercaptalbumin ,Immunology ,Angiotensin-Converting Enzyme 2 ,Disease Susceptibility ,business ,EGCG, epigallocatechin gallate ,HSA, human serum albumin ,medicine.drug - Abstract
The severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) keeps on destroying normal social integrity worldwide, bringing about extraordinary medical services, cultural and financial interruption. Individuals with diabetes have been demonstrated to be at higher risk of complications and even death when exposed to SARS-CoV-2. Regardless of pandemic scale infection, there is presently limited comprehension on the potential impact of SARS-CoV-2 on individuals with diabetes. Human serum albumin (HSA) is the most abundant circulating plasma protein in human serum and attracted more interest from researchers because most susceptible to non-enzymatic glycation reactions. Albumin down-regulates the expression of ACE2 that is the target receptor of COVID-19. Hypoalbuminemia, coagulopathy, and vascular disease have been connected in COVID-19 and appear to predict outcomes independent of age and morbidity. This review discusses the most recent evidence that the ACE/ACE2 ratio could influence by human serum albumin both the susceptibility of individuals to SARS-CoV-2 infection and the outcome of the COVID-19 disease.
- Published
- 2021