1. Genome‐wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci
- Author
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Erik D Wiström, Nils Eiel Steen, Weiqiu Cheng, Olav B. Smeland, Srdjan Djurovic, Naz Karadag, Ole A. Andreassen, Anders M. Dale, Oleksandr Frei, Kevin S. O’Connell, Alexey A. Shadrin, Guy Hindley, Shahram Bahrami, and Aihua Lin
- Subjects
Genetics ,Bipolar Disorder ,Alcohol Drinking ,Medicine (miscellaneous) ,Genome-wide association study ,Alcohol use disorder ,Biology ,medicine.disease ,Polymorphism, Single Nucleotide ,Comorbidity ,Genetic architecture ,Alcoholism ,Psychiatry and Mental health ,Genetic Loci ,Schizophrenia ,mental disorders ,medicine ,Humans ,SNP ,Genetic Predisposition to Disease ,Bipolar disorder ,Genome-Wide Association Study ,Genetic association - Abstract
Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol consumption (AC) have been linked to greater illness severity. We aimed to identify genomic loci jointly associated with SCZ, BD, AUD and AC to gain further insights into their shared genetic architecture. Design We analysed summary data (P values and Z scores) from genome-wide association studies (GWAS) using conjunctional false discovery rate (conjFDR) analysis, which increases power to discover shared genomic loci. We functionally characterized the identified loci using publicly available biological resources. Setting AUD and AC data provided by the Million Veteran Program, derived from the United States Department of Veterans Affairs Healthcare System. SCZ and BD data provided by the Psychiatric Genomics Consortium, based on cohorts from countries in Europe, North America and Australia. Participants AUD (34 658 cases, 167 346 controls), AC (n = 200 680), SCZ (31 013 cases and 38 918 controls), BD (20 352 cases and 31 358 controls). All participants were of European ancestry. Measurements Genomic loci shared between alcohol traits, SCZ and BD at conjFDR
- Published
- 2021