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4 results on '"J. Bernzen"'

1. Impaired serum cortisol stress response is a predictor of early relapse.

Author

Junghanns K, Backhaus J, Tietz U, Lange W, Bernzen J, Wetterling T, Rink L, and Driessen M

Subjects
Adult, Alcoholism complications, Analysis of Variance, Anxiety Disorders complications, Area Under Curve, Chi-Square Distribution, Humans, Male, Predictive Value of Tests, Recurrence, Temperance, Alcoholism blood, Anxiety Disorders blood, Hydrocortisone blood, Stress, Psychological complications
Abstract

Aims: to investigate a possible association of cortisol stress response during early abstention with relapse., Methods: Thirty-six alcohol-dependent males, half of them with a comorbid anxiety disorder, and 15 healthy controls were exposed to a standardized psychosocial stress test. Thirty-one of the patients were assessed for relapse 6 weeks after discharge., Results: The relapsers showed almost no cortisol responses in the stress test. Comorbid anxiety disorder influenced neither stress response nor relapse., Conclusions: During early abstention from alcohol, reduced stress-responsivity of the hypothalamo-pituitary-adrenocortical axis seems to be connected to early relapse.

Published
2003
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2. Comorbid anxiety and affective disorder in alcohol-dependent patients seeking treatment: the first Multicentre Study in Germany.

Author

Schneider U, Altmann A, Baumann M, Bernzen J, Bertz B, Bimber U, Broese T, Broocks A, Burtscheidt W, Cimander KF, Degkwitz P, Driessen M, Ehrenreich H, Fischbach E, Folkerts H, Frank H, Gurth D, Havemann-Reinecke U, Heber W, Heuer J, Hingsammer A, Jacobs S, Krampe H, Lange W, Lay T, Leimbach M, Lemke MR, Leweke M, Mangholz A, Massing W, Meyenberg R, Porzig J, Quattert T, Redner C, Ritzel G, Rollnik JD, Sauvageoll R, Schläfke D, Schmid G, Schröder H, Schwichtenberg U, Schwoon D, Seifert J, Sickelmann I, Sieveking CF, Spiess C, Stiegemann HH, Stracke R, Straetgen HD, Subkowski P, Thomasius R, Tretzel H, Verner LJ, Vitens J, Wagner T, Weirich S, Weiss I, Wendorff T, Wetterling T, Wiese B, and Wittfoot J

Subjects
Adult, Alcohol Drinking psychology, Alcoholism psychology, Anxiety psychology, Comorbidity, Female, Germany epidemiology, Humans, Male, Middle Aged, Mood Disorders psychology, Psychiatric Status Rating Scales, Socioeconomic Factors, Substance Withdrawal Syndrome psychology, Alcoholism epidemiology, Anxiety epidemiology, Mood Disorders epidemiology
Abstract

The goals of this study were to describe demographic variables, drinking history, and the 6-month prevalence of Axis I comorbidity among alcohol-dependent subjects in GERMANY: The variables: amount of alcohol consumption, age at onset of the first alcohol consumed, age at onset of daily alcohol consumption, age at onset of withdrawal symptoms and number of detoxifications were related to the different comorbid disorders and gender. In this study, 556 patients from 25 alcohol treatment centres were enrolled between 1 January 1999 and 30 April 1999. After a minimum of 10 days of sobriety patients who fulfilled ICD-10 and DSM-IV criteria of alcohol dependence were interviewed for data collection using the Mini-DIPS (German version of the Anxiety Disorders Interview Schedule) and a standardized psychosocial interview. The 6-month prevalence of comorbid Axis I disorders was 53.1%. Among the patients with comorbidity, affective and anxiety disorders were most frequent. Comorbid stress disorder was associated with an early start of drinking, an early beginning of withdrawal symptoms, highest number of detoxifications, and the highest amount of alcohol consumed. Female patients with anxiety disorder consumed more alcohol and started earlier than females without this comorbid disorder. The data do not answer the question of the pathogenesis of comorbid disorders and alcoholism, but indicate that stress disorders in alcoholic patients and anxiety disorders in female alcoholics influence the course and severity of alcoholism.

Published
2001
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3. IMPAIRED SERUM CORTISOL STRESS RESPONSE IS A PREDICTOR OF EARLY RELAPSE

Author

Wolfgang Lange, J. Bernzen, T. Wetterling, Lothar Rink, Klaus Junghanns, U. Tietz, Jutta Backhaus, and Martin Driessen

Subjects
Adult, Male, medicine.medical_specialty, Hydrocortisone, Temperance, Early Relapse, Fight-or-flight response, Predictive Value of Tests, Recurrence, Internal medicine, medicine, Humans, Psychiatry, Analysis of Variance, Chi-Square Distribution, General Medicine, Anxiety Disorders, Alcoholism, Predictive value of tests, Area Under Curve, Anxiety, Analysis of variance, medicine.symptom, Psychology, Chi-squared distribution, Serum cortisol, Stress, Psychological, medicine.drug
Abstract

— Aims: to investigate a possible association of cortisol stress response during early abstention with relapse. Methods: Thirty-six alcohol-dependent males, half of them with a comorbid anxiety disorder, and 15 healthy controls were exposed to a standardized psychosocial stress test. Thirty-one of the patients were assessed for relapse 6 weeks after discharge. Results: The relapsers showed almost no cortisol responses in the stress test. Comorbid anxiety disorder influenced neither stress response nor relapse. Conclusions: During early abstention from alcohol, reduced stress-responsivity of the hypothalamo–pituitary–adrenocortical axis seems to be connected to early relapse.

Published
2003

4. Comorbid anxiety and affective disorder in alcohol-dependent patients seeking treatment: The first multicentre study in Germany

Author

J Wittfoot, W Burtscheidt, W Lange, R Stracke, I Sickelmann, Here Folkerts, H H Stiegemann, M Driessen, U Schwichtenberg, H Schröder, A. Mangholz, J Porzig, Thilo Wagner, H Frank, Henning Krampe, J Bernzen, T Lay, A Altmann, M R Lemke, Hannelore Ehrenreich, W Heber, D Schläfke, A Hingsammer, J Seifert, R Meyenberg, U Bimber, M Leimbach, Rainer Thomasius, J D Rollnik, L J Verner, W Massing, K F Cimander, T Broese, H D Straetgen, J Heuer, Ursula Havemann-Reinecke, D Gurth, B Wiese, A Broocks, S Jacobs, T Wendorff, Dirk Schwoon, G Ritzel, P Subkowski, B Bertz, C Redner, E Fischbach, G Schmid, M Baumann, U Schneider, C Spiess, T Quattert, H Tretzel, T Wetterling, I Weiss, J Vitens, P Degkwitz, R Sauvageoll, M Leweke, S Weirich, and C F Sieveking

Subjects
Adult, Male, medicine.medical_specialty, Alcohol Drinking, Alcohol, Comorbidity, Anxiety, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Sobriety, Germany, medicine, Humans, Psychiatry, Psychiatric Status Rating Scales, Mood Disorders, Public health, Alcohol dependence, General Medicine, Middle Aged, medicine.disease, Substance Withdrawal Syndrome, 030227 psychiatry, 3. Good health, Alcoholism, Socioeconomic Factors, chemistry, Female, medicine.symptom, Psychology, Psychosocial, 030217 neurology & neurosurgery, Anxiety disorder
Abstract

The goals of this study were to describe demographic variables, drinking history, and the 6-month prevalence of Axis I comorbidity among alcohol-dependent subjects in Germany. The variables: amount of alcohol consumption, age at onset of the firs t alcohol consumed, age at onset of daily alcohol consumption, age at onset of withdrawal symptoms and number of detoxifications were related to the different comorbid disorders and gender. In this study, 556 patients from 25 alcohol treatment centres were enro lled between 1 January 1999 and 30 April 1999. After a minimum of 10 days of sobriety patients who fulfilled ICD-10 and DSM-IV crite ria of alcohol dependence were interviewed for data collection using the Mini-DIPS (German version of the Anxiety Disorders Intervi ew Schedule) and a standardized psychosocial interview. The 6-month prevalence of comorbid Axis I disorders was 53.1%. Among the patients with comorbidity, affective and anxiety disorders were most frequent. Comorbid stress disorder was associated with an early start of drinking, an early beginning of withdrawal symptoms, highest number of detoxifications, and the highest amount of alco hol consumed. Female patients with anxiety disorder consumed more alcohol and started earlier than females without this comorbid di s- order. The data do not answer the question of the pathogenesis of comorbid disorders and alcoholism, but indicate that stress d isorders in alcoholic patients and anxiety disorders in female alcoholics influence the course and severity of alcoholism.

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