Search

Abstract: Four dihydrothiophene-condensed chromones including two new compounds oxalicumones D–E (1–2) and known oxalicumones A–B (3–4), along with five other known chromones were isolated from a culture broth of the marine gorgonian-associated fungus Penicillium oxalicum SCSGAF 0023. The structures of 1–2 were elucidated by spectroscopic analysis. Eleven derivatives 3a–3i and 4a–4b were obtained from the acylation of 3 and 4, respectively. Compounds 1–4, 3a–3e, 3g–3h, and 4b showed significant cytotoxicity against several carcinoma cell lines with IC50 ⩽10μM. And their structure–bioactivity relationship was discussed. [Copyright &y& Elsevier]