Search

Your search keyword '"Staudinger/aza-Wittig"' showing total 2 results
Start Over Descriptor "Staudinger/aza-Wittig" Topic aldehydes
2 results on '"Staudinger/aza-Wittig"'

1. One-Pot Sequence of Staudinger/aza-Wittig/Castagnoli-Cushman Reactions Provides Facile Access to Novel Natural-like Polycyclic Ring Systems.

Author

Lebedev R, Dar'in D, Kantin G, Bakulina O, and Krasavin M

Subjects
Aldehydes, Anhydrides
Abstract

Realization of the one-pot Staudinger/aza-Wittig/Castagnoli-Cushman reaction sequence for a series of azido aldehydes and homophthalic anhydrides is described. The reaction proceeded at room temperature and delivered novel polyheterocycles related to the natural product realm in high yields and high diastereoselectivity. The methodology has been extended to three other cyclic anhydrides. These further unravel the potential of the Castagnoli-Cushman reaction in generating polyheterocyclic molecular scaffolds., Competing Interests: The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Published
2022
Full Text
View/download PDF

2. One-Pot Sequence of Staudinger/aza-Wittig/Castagnoli–Cushman Reactions Provides Facile Access to Novel Natural-like Polycyclic Ring Systems

Author

Rodion Lebedev, Dmitry Dar’in, Grigory Kantin, Olga Bakulina, and Mikhail Krasavin

Subjects
Aldehydes, Chemistry (miscellaneous), Organic Chemistry, Drug Discovery, Molecular Medicine, Pharmaceutical Science, Physical and Theoretical Chemistry, Staudinger/aza-Wittig, Castagnoli–Cushman, imine, homophthalic anhydride, lactam, azide, Anhydrides, Analytical Chemistry
Abstract

Realization of the one-pot Staudinger/aza-Wittig/Castagnoli–Cushman reaction sequence for a series of azido aldehydes and homophthalic anhydrides is described. The reaction proceeded at room temperature and delivered novel polyheterocycles related to the natural product realm in high yields and high diastereoselectivity. The methodology has been extended to three other cyclic anhydrides. These further unravel the potential of the Castagnoli–Cushman reaction in generating polyheterocyclic molecular scaffolds.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results