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Your search keyword '"Rapini, Gabriella"' showing total 7 results
Start Over Author "Rapini, Gabriella" Topic alexithymia
7 results on '"Rapini, Gabriella"'

1. Alexithymia, suicide ideation, affective temperaments and homocysteine levels in drug naïve patients with post-traumatic stress disorder: an exploratory study in the everyday ‘real world’ clinical practice: an exploratory study in the everyday 'real world' clinical practice

Author

De Berardis, Domenico, Vellante, Federica, Fornaro, Michele, Anastasia, Annalisa, Olivieri, Luigi, Rapini, Gabriella, Serroni, Nicola, Orsolini, Laura, Valchera, Alessandro, Carano, Alessandro, Tomasetti, Carmine, Varasano, Paola Annunziata, Pressanti, Gabriella Lucidi, Bustini, Massimiliano, Pompili, Maurizio, Serafini, Gianluca, Perna, Giampaolo, Martinotti, Giovanni, Di Giannantonio, Massimo, and RS: MHeNs - R2 - Mental Health

Subjects
Alexithymia, RISK, SYMPTOMS, CHARACTER, PTSD, temperaments, homocysteine, MAJOR DEPRESSION, ASSOCIATION, suicide ideation, COGNITIVE DECLINE, SERUM-LIPID LEVELS, post-traumatic stress disorder, feelings, METAANALYSIS, SCALE
Abstract

Objective: The present exploratory study aimed to investigate relationships between alexithymia, suicide ideation, affective temperaments and homocysteine levels among drug-naive adult outpatients with Post-Traumatic Stress Disorder (PTSD) in an everyday 'real world' clinical setting. Method: Sixty-four adult outpatients with PTSD were evaluated using the Davidson Trauma Scale (DTS), the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation (SSI), the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire. As well, homocysteine levels were measured. Results: Alexithymic subjects showed higher values on all scales but not homocysteine levels. Partial correlations showed that almost all studied variables were correlated with each other, except homocysteine levels. Regression analysis showed that higher disorder severity as measured by DTS and TAS-20 'Difficulty in Identifying Feelings' dimension was associated with higher SSI scores. Conclusions: In conclusion, alexithymic PTSD outpatients may be characterised by higher disorder severity and difficulty in identifying feelings that may be linked to increased suicide ideation, regardless of affective temperaments or homocysteine levels. Homocysteine levels were not related to any studied variable. However, study limitations are discussed and must be considered.Keypoints Patients with alexithymia showed increased PTSD severity, a higher score on TEMPS-A subscales, and more severe suicide ideation. The Difficulty in Identifying Feelings (DIF) dimension of TAS-20 was associated with suicide ideation in patients with PTSD. Homocysteine did not correlate with any studied variables. This study was exploratory and cross-sectional: further larger and prospective studies are needed.

Published
2020

2. Alexithymia, resilience, somatic sensations and their relationships with suicide ideation in drug naïve patients with first‐episode major depression: An exploratory study in the "real world" everyday clinical practice.

Author

De Berardis, Domenico, Fornaro, Michele, Valchera, Alessandro, Rapini, Gabriella, Di Natale, Serena, De Lauretis, Ida, Serroni, Nicola, Orsolini, Laura, Tomasetti, Carmine, Bustini, Massimiliano, Carano, Alessandro, Vellante, Federica, Perna, Giampaolo, Core, Laura, Alessandrini, Marco, Fraticelli, Silvia, Martinotti, Giovanni, and Di Giannantonio, Massimo

Subjects
SOMATIC sensation, MENTAL depression, ALEXITHYMIA, SUICIDE risk factors, PSYCHOLOGICAL resilience, SUICIDAL ideation
Abstract

Aim: The present study is aimed at revaluating alexithymia, somatic sensations, resilience and their relationships with suicide ideation in drug naïve adult outpatients suffering from first episode major depression (MD). Methods: Data of 103 adult outpatients (49 men, 56 women) with a diagnostic and statistical manual of mental disorders, 4th edition, text revision (DSM‐IV‐TR) diagnosis of MD were analysed. Alexithymia was measured using the 20‐item Toronto Alexithymia Scale (TAS‐20) and resilience with the 25 items Connor‐Davidson Resilience Scale (CD‐RISC) whereas depression was evaluated using the 17‐item Hamilton Depression Rating Scale, somatic sensations with the Body Sensations Questionnaire and suicide ideation with Scale of Suicide Ideation (SSI). Results: Gender comparisons between all demographic and clinical variables showed no significant differences in all variables. Subjects who were found positive for alexithymia showed higher scores on all clinical variables controlling for age, gender and duration of the current episode. In a linear regression model, lower scores on CD‐RISC and Difficulty in Identifying Feelings dimension of TAS‐20 were significantly predictive of higher scores on SSI. Conclusions: Alexithymia and low resilience were significant predictors of increased suicide ideation in a first MD episode. However, study limitations must be considered and future research needs are being discussed. [ABSTRACT FROM AUTHOR]

Published
2020
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3. Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the "Real World" Clinical Practice.

Author

De Berardis, Domenico, Olivieri, Luigi, Rapini, Gabriella, Di Natale, Serena, Serroni, Nicola, Fornaro, Michele, Orsolini, Laura, Valchera, Alessandro, Carano, Alessandro, Vellante, Federica, Varasano, Paola Annunziata, Pressanti, Gabriella Lucidi, Serafini, Gianluca, Pompili, Maurizio, Martinotti, Giovanni, and Di Giannantonio, Massimo

Subjects
HOMOCYSTEINE, MENTAL depression, HAMILTON Depression Inventory, ALEXITHYMIA, SUICIDE
Abstract

Objective: This study was performed to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naïve outpatients with major depressive disorder (MDD). Methods: Sixty seven outpatients with MDD with melancholic features were evaluated by the means of the Hamilton Depression Rating Scale, the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation, and homocysteine levels. Results: Alexithymic subjects showed higher scores on all scales and higher homocysteine levels. Regression analysis shown higher homocysteine levels and TAS-20' "Difficulty in Describing Feelings" dimension, in turn being associated with higher suicide ideation. Conclusion: In conclusion, alexithymic MDD outpatients may characterize for homocysteine dysregulation that may be linked to suicide ideation, regardless depression' severity. However, study limitations are discussed and must be considered. [ABSTRACT FROM AUTHOR]

Published
2019
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4. Alexithymia, Suicide Ideation, C-Reactive Protein, and Serum Lipid Levels Among Outpatients with Generalized Anxiety Disorder.

Author

De Berardis, Domenico, Serroni, Nicola, Campanella, Daniela, Marini, Stefano, Rapini, Gabriella, Valchera, Alessandro, Iasevoli, Felice, Mazza, Monica, Fornaro, Michele, Perna, Giampaolo, Di Iorio, Giuseppe, Martinotti, Giovanni, and Di Giannantonio, Massimo

Subjects
GENERALIZED anxiety disorder, ALEXITHYMIA, SUICIDAL ideation, C-reactive protein, BLOOD lipids, DIAGNOSIS, CHOLESTEROL metabolism, MENTAL depression, HIGH density lipoproteins, LOW density lipoproteins, REGRESSION analysis, TRIGLYCERIDES, ANXIETY disorders, PSYCHOLOGY
Abstract

The aim of the present study was to investigate the relationships between alexithymia, suicide ideation, C-Reactive Protein (CRP), and serum lipid levels in adult outpatients with a DSM-IV diagnosis of Generalized Anxiety Disorder (GAD). Seventy consecutive patients with GAD were recruited and evaluated. Measures were the Hamilton Anxiety Scale, the Toronto Alexithymia Scale (TAS–20), the Scale of Suicide Ideation (SSI), and the Montgomery Åsberg Depression Rating Scale (MADRS). All patients were assessed for: CRP, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceridaemia (TG), and very-low-density lipoprotein cholesterol (VLDL-C). TC/HDL-C and LDL-C/HDL-C ratios were also evaluated. Alexithymic patients showed higher scores on almost all rating scales and altered serum CRP and lipid levels vs. non-alexithymics. In the hierarchical regression model, the presence of higher MADRS scores together with higher scores at the Difficulty in Identifying Feelings dimension of TAS-20 were associated with higher rates of suicide ideation. Although alexithymic subjects with GAD may show a CRP and cholesterol dysregulation, this latter seems independent on increased suicide ideation, rather to Difficulty in Identifying Feelings, and subthreshold depressive symptoms. Study limitations and future research implications are discussed. [ABSTRACT FROM PUBLISHER]

Published
2017
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5. Alexithymia, suicidal ideation, and serum lipid levels among drug-naïve outpatients with obsessive-compulsive disorder.

Author

De Berardis, Domenico, Serroni, Nicola, Marini, Stefano, Rapini, Gabriella, Carano, Alessandro, Valchera, Alessandro, Iasevoli, Felice, Mazza, Monica, Signorelli, Maria, Aguglia, Eugenio, Perna, Giampaolo, Martinotti, Giovanni, Varasano, Paola A., Lucidi Pressanti, Gabriella, and Di Giannantonio, Massimo

Subjects
*ALEXITHYMIA, *SUICIDAL ideation, *OBSESSIVE-compulsive disorder, *PSYCHIATRIC rating scales, *BLOOD lipids, *REGRESSION analysis
Abstract

Objective: As obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder with a significant suicide risk, the individuation of potential biomarkers of suicidality, such as cholesterol levels, may enable recognition of at-risk subjects. Therefore, the aims of this study were to: 1) evaluate potential differences in clinical and laboratory parameters between patients with and without alexithymia and compare them with healthy controls; and 2) investigate which clinical and laboratory variables were associated with suicidal ideation. Methods: 79 drug-naïve adult outpatients with a DSM-IV diagnosis of OCD were recruited. Alexithymia was measured with the 20-item Toronto Alexithymia Scale (TAS-20), suicidal ideation was assessed with the Scale for Suicide Ideation, and depressive symptoms were evaluated with the Montgomery-Åsberg Depression Rating Scale (MADRS). Serum lipid levels of 40 healthy controls were also evaluated. Results: Alexithymic patients had altered serum lipid levels in comparison with non-alexithymics and healthy controls. Using a linear regression model, the presence of symmetry/ordering obsessions and compulsions, lower HDL-C levels, and difficulty in identifying feelings dimension of the TAS-20 were associated with higher suicidal ideation. Conclusions: Alexithymic individuals with OCD may exhibit dysregulation of the cholesterol balance, which in turn may be linked to suicidal ideation. Further prospective studies are required to elucidate this potential association. [ABSTRACT FROM AUTHOR]

Published
2014
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6. Alexithymia, Suicide Ideation, C-Reactive Protein, and Serum Lipid Levels Among Outpatients with Generalized Anxiety Disorder

Author

Monica Mazza, Giuseppe Di Iorio, Michele Fornaro, Nicola Serroni, Domenico De Berardis, Giovanni Martinotti, Gabriella Rapini, Giampaolo Perna, Felice Iasevoli, Stefano Marini, Massimo Di Giannantonio, Alessandro Valchera, Daniela Campanella, De Berardis, Domenico, Serroni, Nicola, Campanella, Daniela, Marini, Stefano, Rapini, Gabriella, Valchera, Alessandro, Iasevoli, Felice, Mazza, Monica, Fornaro, Michele, Perna, Giampaolo, Di Iorio, Giuseppe, Martinotti, Giovanni, and Di Giannantonio, Massimo

Subjects
Alexithymia, Male, serum lipid levels, Cholesterol, VLDL, Poison control, Suicide prevention, Triglyceride, chemistry.chemical_compound, Toronto Alexithymia Scale, 0302 clinical medicine, medicine.diagnostic_test, Affective Symptom, Depression, Anxiety Disorders, Clinical Psychology, Cholesterol, Psychiatry and Mental Health, suicide ideation, Montgomery–Åsberg Depression Rating Scale, Linear Model, lipids (amino acids, peptides, and proteins), Female, Psychology, VLDL, Anxiety Disorder, Clinical psychology, Human, Adult, Generalized anxiety disorder, HDL, C-reactive protein, generalized anxiety disorder, Affective Symptoms, C-Reactive Protein, Cholesterol, HDL, Cholesterol, LDL, Humans, Linear Models, Triglycerides, Young Adult, Suicidal Ideation, LDL, 03 medical and health sciences, Rating scale, medicine, medicine.disease, 030227 psychiatry, serum lipid level, chemistry, 030217 neurology & neurosurgery
Abstract

The aim of the present study was to investigate the relationships between alexithymia, suicide ideation, C-Reactive Protein (CRP), and serum lipid levels in adult outpatients with a DSM-IV diagnosis of Generalized Anxiety Disorder (GAD). Seventy consecutive patients with GAD were recruited and evaluated. Measures were the Hamilton Anxiety Scale, the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation (SSI), and the Montgomery Åsberg Depression Rating Scale (MADRS). All patients were assessed for: CRP, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceridaemia (TG), and very-low-density lipoprotein cholesterol (VLDL-C). TC/HDL-C and LDL-C/HDL-C ratios were also evaluated. Alexithymic patients showed higher scores on almost all rating scales and altered serum CRP and lipid levels vs. non-alexithymics. In the hierarchical regression model, the presence of higher MADRS scores together with higher scores at the Difficulty in Identifying Feelings dimension of TAS-20 were associated with higher rates of suicide ideation. Although alexithymic subjects with GAD may show a CRP and cholesterol dysregulation, this latter seems independent on increased suicide ideation, rather to Difficulty in Identifying Feelings, and subthreshold depressive symptoms. Study limitations and future research implications are discussed.

Published
2017

7. Alexithymia, responsibility attitudes and suicide ideation among outpatients with obsessive-compulsive disorder: an exploratory study

Author

Barbara Feliziani, Nicola Serroni, Marco Di Nicola, Monica Mazza, Massimo Di Giannantonio, Domenico De Berardis, Carmine Tomasetti, Daniela Campanella, Gabriella Rapini, Felice Iasevoli, Alessandro Carano, Luigi Olivieri, Giampaolo Perna, Michele Fornaro, Giovanni Martinotti, Alessandro Valchera, De Berardis, Domenico, Serroni, Nicola, Campanella, Daniela, Rapini, Gabriella, Olivieri, Luigi, Feliziani, Barbara, Carano, Alessandro, Valchera, Alessandro, Iasevoli, Felice, Tomasetti, Carmine, Mazza, Monica, Fornaro, Michele, Perna, Giampaolo, Di Nicola, Marco, Martinotti, Giovanni, Di Giannantonio, Massimo, Psychiatrie & Neuropsychologie, and RS: MHeNs - R2 - Mental Health

Subjects
Adult, Male, Risk, medicine.medical_specialty, Obsessive-Compulsive Disorder, Adolescent, lcsh:RC435-571, Poison control, Neuropsychological Tests, Suicide prevention, Suicidal Ideation, Toronto Alexithymia Scale, Young Adult, Alexithymia, lcsh:Psychiatry, Injury prevention, Outpatients, medicine, Humans, Affective Symptoms, Young adult, Psychiatry, Suicidal ideation, Psychiatric Status Rating Scales, medicine.diagnostic_test, Affective Symptom, Depression, Outpatient, Psychiatric Status Rating Scale, Middle Aged, medicine.disease, Clinical Psychology, Attitude, Psychiatry and Mental Health, Montgomery–Åsberg Depression Rating Scale, Neuropsychological Test, Female, medicine.symptom, Psychology, Clinical psychology, Human
Abstract

Aims Obsessive-compulsive disorder (OCD) is psychiatric disorder with a significant suicide risk, and the presence of alexithymia may increase this risk. As several studies attribute an important role, in OCD, to responsibility, the aims of this study were to evaluate possible clinical differences between patients positive or not for alexithymia concerning disorder severity, responsibility attitudes and suicide ideation and investigate which variables were associated with increased suicide ideation. Methods 104 adult outpatients with OCD were recruited. Alexithymia was measured with Toronto Alexithymia Scale (TAS-20), attitude about responsibility was tested with Responsibility Attitude Scale (RAS), suicide ideation was assessed with Scale of Suicide Ideation (SSI) and depressive symptoms were evaluated with Montgomery Asberg Depression Rating Scale (MADRS). Score of item #11 on the Y-BOCS was considered as a measure of insight. Results Patients positive for alexithymia showed higher responsibility attitudes and more severe suicide ideation. In a blockwise regression model, the presence of lower insight, higher RAS scores and difficulty in identifying feelings dimension of TAS-20 were associated with higher SSI scores. Conclusions OCD patients with alexithymia may show higher disorder severity, lower insight and inflated responsibility, all related to suicide ideation, independently from depressive symptoms. Implications were discussed and study limitations considered and reported.

Published
2014

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