1. Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer.
- Author
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Mousazadeh, Navid, Seidi, Farzad, Ghaffarlou, Mohammadreza, Rashidzadeh, Hamid, Hosseinmirzaei, Ali, Mozafari, Faezeh, Danafar, Hossein, and Nosrati, Hamed
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SILVER sulfide , *CANCER radiotherapy , *ALGINIC acid , *SILVER nanoparticles , *CYTOCOMPATIBILITY , *X-rays - Abstract
A wide range of high-Z nanomaterials are fabricated to decrease radiation dose by sensitizing cells to irradiation through various mechanisms such as ROS generation enhancement. Alginate-coated silver sulfide nanoparticles (Ag 2 S@Alg) were synthesized and characterized by SEM, TEM, DLS, XRD, EPS, FT-IR, and UV–vis analysis techniques. Cytotoxicity of nanoparticles was tested against HFF-2, MCF-7, and 4 T1 cell lines for biocompatibility and radio enhancement ability evaluation, respectively. Moreover, the hemolysis assay demonstrated that the nanoparticles were biocompatible and nontoxic. In vitro intracellular ROS generation and calcein AM/PI co-staining unveiled cancerous cell death induction by nanoradiosensitizer, Ag 2 S@Alg. Further, histopathology results emphasized the tumor ablation capability of Ag 2 S@Alg. Silver anticancer properties were also recognized and combined with its radiosensitizing effect under X-ray irradiation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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