1. Determining Complete Chromosomal Haplotypes by mLinker.
- Author
-
Sinha S and Zhang CZ
- Subjects
- Humans, Haplotypes genetics, Genotype, Chromosomes, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Algorithms, Genome, Human
- Abstract
Haplotype ("haploid genotype") phase is the combination of genotypes at sites of genetic variation along a chromosome [1]. We previously demonstrated that the complete chromosomal haplotype of diploid human genomes can be determined using molecular linkage from Hi-C sequencing and linked-reads sequencing [2]. In this chapter, we present a step-by-step guide to perform this analysis using mLinker, a software package for haplotype inference., (© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2023
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