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Interstitial fibrosis in renal biopsy samples is a scarring tissue structure that may be visually quantified by pathologists as an indicator to the presence and extent of chronic kidney disease. The standard method of quantification by visual evaluation presents reproducibility issues in the diagnoses. This study proposes an automated quantification system for measuring the amount of interstitial fibrosis in renal biopsy images as a consistent basis of comparison among pathologists. The system extracts and segments the renal tissue structures based on colour information and structural assumptions of the tissue structures. The regions in the biopsy representing the interstitial fibrosis are deduced through the elimination of non-interstitial fibrosis structures from the biopsy area and quantified as a percentage of the total area of the biopsy sample. A ground truth image dataset has been manually prepared by consulting an experienced pathologist for the validation of the segmentation algorithms. The results from experiments involving experienced pathologists have demonstrated a good correlation in quantification result between the automated system and the pathologists’ visual evaluation. Experiments investigating the variability in pathologists also proved the automated quantification error rate to be on par with the average intra-observer variability in pathologists’ quantification. Background and Objective Interstitial fibrosis in renal biopsy samples is a scarring tissue structure that may be visually quantified by pathologists as an indicator to the presence and extent of chronic kidney disease. The standard method of quantification by visual evaluation presents reproducibility issues in the diagnoses due to the uncertainties in human judgement. Methods An automated quantification system for accurately measuring the amount of interstitial fibrosis in renal biopsy images is presented as a consistent basis of comparison among pathologists. The system identifies the renal tissue structures through knowledge-based rules employing colour space transformations and structural features extraction from the images. In particular, the renal glomerulus identification is based on a multiscale textural feature analysis and a support vector machine. The regions in the biopsy representing interstitial fibrosis are deduced through the elimination of non-interstitial fibrosis structures from the biopsy area. The experiments conducted evaluate the system in terms of quantification accuracy, intra- and inter-observer variability in visual quantification by pathologists, and the effect introduced by the automated quantification system on the pathologists’ diagnosis. Results A 40-image ground truth dataset has been manually prepared by consulting an experienced pathologist for the validation of the segmentation algorithms. The results from experiments involving experienced pathologists have demonstrated an average error of 9 percentage points in quantification result between the automated system and the pathologists’ visual evaluation. Experiments investigating the variability in pathologists involving samples from 70 kidney patients also proved the automated quantification error rate to be on par with the average intra-observer variability in pathologists’ quantification. Conclusions The accuracy of the proposed quantification system has been validated with the ground truth dataset and compared against the pathologists’ quantification results. It has been shown that the correlation between different pathologists’ estimation of interstitial fibrosis area has significantly improved, demonstrating the effectiveness of the quantification system as a diagnostic aide. [ABSTRACT FROM AUTHOR]

A multisine excitation signal enables fast and statistically robust measurement of the nonlinear behavior of analog devices under test. This paper describes the design considerations and constraints of a multisine excitation signal when it is applied to analog-to-digital converter testing. A novel phase-plane uniformity objective function followed by an optimization procedure is proposed to optimize the multisine excitation signal. Performance comparison between the proposed multisine design and other alternative multisine design is carried out. It is demonstrated that the proposed phase-space uniform multisine enables better representation of the conversion error distribution compared with existing multisine designs. This results in a more accurate assessment of the analog-to-digital converter performance. [ABSTRACT FROM PUBLISHER]

Alternating decision tree (ADTree) is a special decision tree representation that brings interpretability to boosting, a well-established ensemble algorithm. This has found success in wide applications. However, existing variants of ADTree are implementing univariate decision nodes where potential interactions between features are ignored. To date, there has been no multivariate ADTree. We propose a sparse version of multivariate ADTree such that it remains comprehensible. The proposed sparse ADTree is empirically tested on UCI datasets as well as spectral datasets from the University of Eastern Finland (UEF). We show that sparse ADTree is competitive against both univariate decision trees (original ADTree, C4.5, and CART) and multivariate decision trees (Fisher's decision tree and a single multivariate decision tree from oblique Random Forest). It achieves the best average rank in terms of prediction accuracy, second in terms of decision tree size and faster induction time than existing ADTree. In addition, it performs especially well on datasets with correlated features such as UEF spectral datasets. Thus, the proposed sparse ADTree extends the applicability of ADTree to a wider variety of applications. [ABSTRACT FROM AUTHOR]

High-volume production data shows that dies, which failed probe test on a semiconductor wafer, have a tendency to form certain unique patterns, i.e., defect clusters. Identifying such clusters is one of the crucial steps toward improvement of the fabrication process and design for manufacturing. This paper proposes a new technique for defect-cluster identification that combines data mining with a defect-cluster extraction using a Segmentation, Detection, and Cluster-Extraction algorithm. It offers high defect-extraction accuracy, without any significant increase in test time and cost. [ABSTRACT FROM PUBLISHER]