1. Aliphatic Organoimido Derivatives of Polyoxometalates Containing a Bioactive Ligand.
- Author
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She , Shan, Bian, Shengtai, Hao , Jian, Zhang, Jiangwei, Zhang , Jin, and Wei , Yongge
- Subjects
ALIPHATIC amines ,POLYOXOMETALATES ,LIGANDS (Chemistry) ,CELL proliferation ,MOLYBDENUM - Abstract
A series of aliphatic organoimido derivatives of hexamolybdate based on amantadine, namely (nBu
4 N)2 -[Mo6 O18 (≡NC10 H15 )] (1), (nBu4 N)2 {cis-[Mo6 O17 (≡NC10 H15 )2 ]} (2), (nBu4 N)2 {trans-[Mo6 O17 (≡NC10 H15 )2 ]} (3), and (nBu4 N)2 [Mo6 O16 - (≡NC10 H15 )3 ] (4), was synthesized in reasonable yield by dehydration with N,N'-dicyclohexylcarbodiimide (DCC). They were characterized by IR and UV/Vis spectroscopy, elemental analysis, ESI mass spectrometry, and single-crystal X-ray structure analysis. The spectral and structural similarities and differences between monosubstituted, cis-disubstituted, and transdisubstituted organoimido derivatives were elucidated and may provide guidance for related work on organoimido-functionalized Lindqvist-type polyoxometalates. In addition, trans-disubstituted and polysubstituted derivatives containing aliphatic organoimido ligands have not yet been reported, and the crystal structure of the trans isomer may lead us to a deeper understanding of disubstituted derivatives. Furthermore, proliferation and morphology of MCF-7 cells were studied with compound 1. The present results show that the DCC-dehydrating protocol could be an efficient approach to covalently graft bioactive ligands such as amantadine onto POMs and enhance their application in clinical cancer treatment. [ABSTRACT FROM AUTHOR]- Published
- 2014
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