Search

Your search keyword '"Xu, Anyang"' showing total 1 results
Start Over Author "Xu, Anyang" Topic alk

Refine your results

1 results on '"Xu, Anyang"'

1. 3D-QSAR and molecular fragment replacement study on diaminopyrimidine and pyrrolotriazine ALK inhibitors.

Author

Ke, Zhipeng, Lu, Tao, Liu, Haichun, Yuan, Haoliang, Ran, Ting, Zhang, Yanmin, Yao, Sihui, Xiong, Xiao, Xu, Jinxing, Xu, Anyang, and Chen, Yadong

Subjects
*QSAR models, *MOLECULAR structure, *PYRIMIDINES, *TRIAZINES, *PREDICTION models
Abstract

Highlights: [•] We developed CoMFA, CoMSIA and Topomer CoMFA models for a series of ALK inhibitors. [•] Topomer Search was utilized for virtual screening to obtain suitable fragments. [•] Novel compounds were generated by molecular fragment replacement. [•] Novel compounds were evaluated by 3D-QSAR models prediction and docking analysis. [•] A set of novel derivatives with predicted activities were designed. [Copyright &y& Elsevier]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results