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(+)- and (-)-Tedanine [(+)-1 and (-)-1], a pair of new enantiomeric indolone alkaloids, along with nine compounds (2–10) were isolated from the marine sponge Tedania sp. The structures of (+)-1 and (-)-1 including absolute configurations were determined by spectroscopic analysis and quantum chemical calculation. Compounds (+)-1 and (-)-1 were the first examples of indolone alkaloids isolated from this genus. In addition, the cytotoxic and antibacterial activities of these compounds were also evaluated. [ABSTRACT FROM AUTHOR]

Two new alkaloids, spongimides A (1) and B (2), along with five known ones (3–7), were isolated from the marine sponge Spongia sp. The structures of 1 and 2 were determined by the spectroscopic methods (UV, IR, MS, and NMR) and X-ray diffraction analysis. Compounds 1, 3, and 4 were the first examples of 2,4-imidazolidinediones isolated from this genus. In addition, the cytotoxic and antibacterial activities of compounds 1 and 2 were also evaluated. [ABSTRACT FROM AUTHOR]

The phytochemical investigation on the fruits of Flueggea virosa resulted in the discovery of two new norsecurinine-derived alkaloid dimers, norsecurinamines A and B ( 1 and 2 ). Compound 1 is the first hetero-dimeric alkaloid possessing norsecurinine and donaxaridine units, and 2 represents the first example of NH -linked dimeric Securinega alkaloid. Their structures and absolute configuration were elucidated on the basis of extensive spectroscopic analysis as well as single-crystal X-ray diffraction method. A plausible biogenetic pathway of 1 was also proposed. [ABSTRACT FROM AUTHOR]

Astract Two new C 18 -diterpenoid alkaloids, sinomontadine ( 1 ) and sinomontanine N ( 2 ), were isolated from Aconitum sinomontanum . Their structures were determined by spectroscopic methods and X-ray crystallographic analysis. Sinomontadine ( 1 ) features an unprecedented skeleton containing a seven-membered ring (A-ring), while sinomontanine N ( 2 ) is chlorinated. A plausible biogenetic pathway for 1 was proposed. [ABSTRACT FROM AUTHOR]