1. Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels.
- Author
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Martin NJ, Ferreiro SF, Barbault F, Nicolas M, Lecellier G, Paetz C, Gaysinski M, Alonso E, Thomas OP, Botana LM, and Raharivelomanana P
- Subjects
- Alkaloids isolation & purification, Animals, CHO Cells, Cricetulus, HEK293 Cells, Humans, Indole Alkaloids chemistry, Indole Alkaloids isolation & purification, Indoles isolation & purification, Molecular Docking Simulation, Molecular Structure, Plant Bark chemistry, Plant Extracts chemistry, Alkaloids chemistry, Ether-A-Go-Go Potassium Channels antagonists & inhibitors, Indoles chemistry, Rauwolfia chemistry
- Abstract
In addition to the already reported nukuhivensiums 1 and 2, 11 indole alkaloids were isolated from the bark of the plant Rauvolfia nukuhivensis, growing in the Marquesas archipelago. The known sandwicine (3), isosandwicine (4), spegatrine (8), lochneram (9), flavopereirine (13) have been found in this plant together with the norsandwicine (5), isonorsandwicine (6), Nb-methylisosandwicine (7), 10-methoxypanarine (10), nortueiaoine (11), tueiaoine (12). The structure elucidation was performed on the basis of a deep exploration of the NMR and HRESIMS data as well as comparison with literature data for similar compounds. Norsandwicine, 10-methoxypanarine, tueiaoine, and more importantly nukuhivensiums, were shown to significantly induce a reduction of IKr amplitude (HERG current). Molecular modelling through docking was performed in order to illustrate this result., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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