1. Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles
- Author
-
Chang Hsien Tsai, Mei‐Huey Lin, Kung Yu Liang, Hau Chun Wu, Yi Syuan Li, Yu-Chun Chen, Hung Chang Hsiao, and Chung-Hao Chen
- Subjects
Alkylation ,Pharmaceutical Science ,chemistry.chemical_element ,Crystallography, X-Ray ,010402 general chemistry ,01 natural sciences ,coumarin ,Article ,Catalysis ,Analytical Chemistry ,Styrene ,lcsh:QD241-441 ,chemistry.chemical_compound ,lcsh:Organic chemistry ,Drug Discovery ,Molecule ,Organic chemistry ,Physical and Theoretical Chemistry ,Gallium ,indazoles ,regioselective alkylation ,Molecular Structure ,010405 organic chemistry ,Organic Chemistry ,styrene ,fluorescence ,Regioselectivity ,Coumarin ,0104 chemical sciences ,chemistry ,Chemistry (miscellaneous) ,Molecular Medicine - Abstract
A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography. The styrene- and coumarin-2H-indazoles produced by using the new method were found to have interesting fluorescence properties.
- Published
- 2016