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Your search keyword '"Mesini, Philippe"' showing total 2 results
Start Over Author "Mesini, Philippe" Topic alkylation
2 results on '"Mesini, Philippe"'

1. DNA alkylation properties of CC-1065 and duocarmycin analogs incorporating the 2,3,10,10-a...

Author

Boger, Dale L. and Mesini, Philippe

Subjects
*ADENINE nucleotides, *ALKYLATION
Abstract

Identifies subtle structural features that contribute to the regioselectivity of the adenine N3 alkylation reaction. Details of some DNA alkylation properties; Analyses on the adenine N3 adduct obtained by thermal depurination; Benefit of the regiochemcial course of the adenine N3 DNA alkylation reaction; Features that complement regioselectivity.

Published
1995
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2. Chemical and structural comparison of N-BOC-CBQ and N-BOC-CBI: Identification and structural...

Author

Boger, Dale L. and Mesini, Philippe

Subjects
*ANTINEOPLASTIC antibiotics, *SOLVOLYSIS, *ALKYLATION, *CHEMICAL structure
Abstract

Compares the chemical and structural properties of antitumor antibiotics N-BOC-CBQ and N-BOC-CBI. Mechanism of DNA alkylation; Stereoelectronic control of the solvolysis and alkylation reactions; Linear relationship between the chemical stability and cytotoxic potency.

Published
1994
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