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Your search keyword '"Xue, Hongxiang"' showing total 2 results
Start Over Author "Xue, Hongxiang" Topic alkylation
2 results on '"Xue, Hongxiang"'

1. Visible‐Light‐Promoted C(sp 3 )−H Alkylation by Intermolecular Charge Transfer: Preparation of Unnatural α‐Amino Acids and Late‐Stage Modification of Peptides

Author

Rui Wang, Chao Wang, Xue Hongxiang, Rupeng Qi, Yaqiong Chen, Zhaoqing Xu, Yuxuan Shen, and Min Chang

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Salt (chemistry), Peptide, General Chemistry, General Medicine, Alkylation, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Amino acid, chemistry, Glycine, Electrophile, Photocatalysis, Visible spectrum
Abstract

Disclosed herein is the visible-light-promoted deaminative C(sp3 )-H alkylation of glycine and peptides using Katritzky salts as electrophiles. Simple reaction conditions and excellent functional-group tolerance provide a general strategy for the efficient preparation of unnatural α-amino acids and precise modification of peptides with unnatural α-amino-acid residues. Mechanistic studies suggest that visible-light-promoted intermolecular charge transfer within a glycine-Katritzky salt electron donor-acceptor (EDA) complex induces a single-electron transfer process without the assistance of photocatalyst.

Published
2020

2. Visible‐Light‐Promoted C(sp3)−H Alkylation by Intermolecular Charge Transfer: Preparation of Unnatural α‐Amino Acids and Late‐Stage Modification of Peptides.

Author

Wang, Chao, Qi, Rupeng, Xue, Hongxiang, Shen, Yuxuan, Chang, Min, Chen, Yaqiong, Wang, Rui, and Xu, Zhaoqing

Subjects
CHARGE transfer, ALKYLATION, PEPTIDES, ACIDS, MODIFICATIONS, CARBON-hydrogen bonds
Abstract

Disclosed herein is the visible‐light‐promoted deaminative C(sp3)−H alkylation of glycine and peptides using Katritzky salts as electrophiles. Simple reaction conditions and excellent functional‐group tolerance provide a general strategy for the efficient preparation of unnatural α‐amino acids and precise modification of peptides with unnatural α‐amino‐acid residues. Mechanistic studies suggest that visible‐light‐promoted intermolecular charge transfer within a glycine–Katritzky salt electron donor‐acceptor (EDA) complex induces a single‐electron transfer process without the assistance of photocatalyst. [ABSTRACT FROM AUTHOR]

Published
2020
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