1. Alkyne Difunctionalization by Dual Gold/Photoredox Catalysis.
- Author
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Tlahuext‐Aca, Adrian, Hopkinson, Matthew N., Garza‐Sanchez, R. Aleyda, and Glorius, Frank
- Subjects
ALKYNES ,CATALYSIS ,NUCLEOPHILIC addition (Chemistry) ,OXIDATION ,AROMATIC compounds - Abstract
Highly selective tandem nucleophilic addition/cross-coupling reactions of alkynes have been developed using visible-light-promoted dual gold/photoredox catalysis. The simultaneous oxidation of Au
I and coordination of the coupling partner by photo-generated aryl radicals, and the use of catalytically inactive gold precatalysts allows for high levels of selectivity for the cross-coupled products without competing hydrofunctionalization or homocoupling. As demonstrated in representative arylative Meyer-Schuster and hydration reactions, this work expands the scope of dual gold/photoredox catalysis to the largest class of substrates for gold catalysts and benefits from the mild and environmentally attractive nature of visible-light activation. [ABSTRACT FROM AUTHOR]- Published
- 2016
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