1. The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis
- Author
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Mohammad Hashemi, G. R. Bardestani, Zahra Zakeri, Moazeni-Roodi A, DorMohammad Kordi-Tamandani, Saeid Ghavami, Mohsen Taheri, Aliakbar Fazaeli, and Mahnaz Sandoughi
- Subjects
Adult ,Male ,Antioxidant ,Genotype ,medicine.medical_treatment ,Polymerase Chain Reaction ,Arthritis, Rheumatoid ,chemistry.chemical_compound ,High-density lipoprotein ,Genetics ,Humans ,Medicine ,Genetic Predisposition to Disease ,Allele ,Molecular Biology ,Polymorphism, Genetic ,biology ,Aryldialkylphosphatase ,business.industry ,Paraoxonase ,General Medicine ,Middle Aged ,medicine.disease ,PON1 ,chemistry ,Rheumatoid arthritis ,Immunology ,biology.protein ,Female ,business ,Lipoprotein - Abstract
Paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that exhibits antioxidant and antiatherogenic activities. We examined a possible association between T172A (L55M) and T(-107)C polymorphisms and rheumatoid arthritis. These polymorphisms were determined in 88 rheumatoid arthritis patients and 78 healthy subjects, using the tetra-amplification refractory mutation system-PCR method. The prevalence of the PON1 55MM genotype was significantly greater among rheumatoid arthritis patients (17%) when compared to control subjects (5.2%) (odds ratio (OR) = 3.75; 95% confidence interval (CI) = 1.87-11.8, P = 0.025). In addition, the M allele was more frequent in rheumatoid arthritis patients (40%) than in healthy subjects (24.7%) (OR = 1.997; 95%CI = 1.243-3.210, P = 0.005). There were no significant differences in the -107C/T polymorphism in the promoter sequence of PON1 between rheumatoid arthritis and normal subjects (chi(2) = 0.861, P = 0.650). In conclusion, the PON1 55MM genotype is a risk factor for rheumatoid arthritis.
- Published
- 2010
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