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A novel allele A*24:337 was identified in a Chinese individual by sequence-based typing., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

A novel allele DRB1*04:01:17 was identified in a Chinese individual by sequence-based typing method., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

A novel allele A*02:436 was identified in a Chinese individual by sequence-based typing method., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

The new allele A*02:01:119 was initially identified in a Chinese individual by sequence-based typing., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Adult body height is a quantitative trait for which genome-wide association studies (GWAS) have identified numerous loci, primarily in European populations. These loci, comprising common variants, explain <10% of the phenotypic variance in height. We searched for novel associations between height and common (minor allele frequency, MAF ≥5%) or infrequent (0.5% < MAF < 5%) variants across the exome in African Americans. Using a reference panel of 1692 African Americans and 471 Europeans from the National Heart, Lung, and Blood Institute's (NHLBI) Exome Sequencing Project (ESP), we imputed whole-exome sequence data into 13 719 African Americans with existing array-based GWAS data (discovery). Variants achieving a height-association threshold of P < 5E-06 in the imputed dataset were followed up in an independent sample of 1989 African Americans with whole-exome sequence data (replication). We used P < 2.5E-07 (=0.05/196 779 variants) to define statistically significant associations in meta-analyses combining the discovery and replication sets (N = 15 708). We discovered and replicated three independent loci for association: 5p13.3/C5orf22/rs17410035 (MAF = 0.10, β = 0.64 cm, P = 8.3E-08), 13q14.2/SPRYD7/rs114089985 (MAF = 0.03, β = 1.46 cm, P = 4.8E-10) and 17q23.3/GH2/rs2006123 (MAF = 0.30; β = 0.47 cm; P = 4.7E-09). Conditional analyses suggested 5p13.3 (C5orf22/rs17410035) and 13q14.2 (SPRYD7/rs114089985) may harbor novel height alleles independent of previous GWAS-identified variants (r(2) with GWAS loci <0.01); whereas 17q23.3/GH2/rs2006123 was correlated with GWAS-identified variants in European and African populations. Notably, 13q14.2/rs114089985 is infrequent in African Americans (MAF = 3%), extremely rare in European Americans (MAF = 0.03%), and monomorphic in Asian populations, suggesting it may be an African-American-specific height allele. Our findings demonstrate that whole-exome imputation of sequence variants can identify low-frequency variants and discover novel variants in non-European populations., (© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

A novel allele B*13:68 was identified in a Chinese individual by sequence-based typing method., (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

The new allele differs from MICA*008:01:01 by a single nucleotide substitution at position 591 of exon 3., (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

The novel allele B*46:01:07 was identified in a Chinese individual by sequence-based typing., (© 2012 John Wiley & Sons A/S.)

A novel allele A*11:97 was identified in a Chinese individual by sequence-based typing method., (© 2012 John Wiley & Sons A/S.)

The allele was identified in a Chinese individual by sequence-based typing. HLA-B*40:162 differs from B*40: 06:01 by a single nucleotide at position 272 C→T in exon 2., (© 2011 John Wiley & Sons A/S.)

In this report we describe a novel allele B*44:127, which was identified in a Chinese voluntary bone marrow donor by sequence-based typing. HLA-B*44:127 showed one nucleotide difference from G to A with HLA-B*44:02:01 at nucleotide 320., (© 2011 John Wiley & Sons A/S.)

Objective: To investigate the allelic frequency of histocompatibility leukocyte antigen (HLA)-DRB of gestational diabetes mellitus (GDM) women, in order to find out the susceptible or protective gene associated with GDM and the relationship between HLA-DRB genes and the clinical characteristic., Methods: Thirty GDM women served as study group, 40 normal pregnant women were selected as control group. The distribution of HLA-DRB alleles frequency of 30 GDM and 40 normalpregnant women was examed by polymerase chain reaction sequence specific primer (PCR-SSP)., Results: There was significantly increased gene frequency of HLA-DR6 (13) in GDM women compared with normal pregnancy (12% Vs 2%, P < 0.05, RR = 5.8). The frequency of HLA-DR3 and HLA-DR9 gene in GDM women were increased, but the statistical difference was not significant (8% Vs 4%, 23% Vs 16%, P > 0.05). A much lower frequency of HLA-DR2 (15), HLA-DR51 were observed in GDM women than in normal pregnancy (10% Vs 24%, P < 0.05; 10% Vs 38%, P < 0.05). There were relationship between HLA-DR3 gene or HLA-DR6 (13)/DR9 heterozygote and severe type of GDM, relative risk (RR) were 27.1 and 8.5 respectively; HLA-DR6 (13)/DR9 heterozygote or HLA-DR3 gene were also correlated with abnormal plasma glucose levels., Conclusions: Alleles HLA-DR6 (13) were significantly implicated in their susceptibility to GDM. Conversely, HLA-DR2 (15), HLA-DR51 alleles might confer protection against GDM. HLA-DR3 gene and HLA-DR6 (13)/DR9 heterozygote were associated with severity and prognosis of GDM. It may be a marker of grade and prognosis of GDM and may direct the treatment.

The novel allele A*26:89 was identified in a Chinese individual by sequence-based typing. [ABSTRACT FROM AUTHOR]

The novel allele A*24:233 was identified in a Chinese individual by sequence-based typing. [ABSTRACT FROM AUTHOR]

The new allele differs from MICA* 008:01:01 by a single nucleotide substitution at position 591 of exon 3. [ABSTRACT FROM AUTHOR]