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Your search keyword '"Mietta S."' showing total 3 results
Start Over Author "Mietta S." Topic allergens
3 results on '"Mietta S."'

1. Italian study on buckwheat allergy: prevalence and clinical features of buckwheat-sensitized patients in Italy.

Author

Badiu I, Olivieri E, Montagni M, Guida G, Mietta S, Pizzimenti S, Caminati M, Yacoub MR, Tombetti E, Preziosi D, Quecchia C, Minetti S, Facchetti S, Fassio F, Massaro I, Corradi L, Turi MC, Colagiovanni A, Pascolini L, Rossi FW, Losappio L, Sansone L, Imbesi S, Leto Barone S, Mistrello G, and Heffler E

Subjects
Adult, Female, Food Hypersensitivity diagnosis, Food Hypersensitivity immunology, Humans, Italy epidemiology, Male, Middle Aged, Predictive Value of Tests, Prevalence, Referral and Consultation, Skin Tests, Young Adult, Allergens, Fagopyrum adverse effects, Food Hypersensitivity epidemiology
Abstract

Buckwheat allergy is considered a rare food allergy outside of Asia. In Europe, buckwheat has been described mainly as a hidden allergen. Data on the prevalence of buckwheat hypersensitivity in non-Asian countries is very poor. The aim of this multicenter study was to evaluate the prevalence of buckwheat sensitization and its association with other sensitizations among patients referred to allergy clinics in different geographic areas of Italy. All patients referred to 18 Italian allergy clinics from February through April 2011 were included in the study and evaluated for sensitization to buckwheat and other allergens depending on their clinical history. A total of 1,954 patients were included in the study and 61.3 percent of them were atopic. Mean prevalence of buckwheat sensitization was 3.6 percent with significant difference between Northern (4.5 percent), Central (2.2 percent) and Southern (2.8 percent) regions. This is, to our knowledge, the largest epidemiological survey on buckwheat allergy reported outside of Asia. Buckwheat is an emerging allergen in Italy, being more frequently associated to sensitization in Northern regions.

Published
2013
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2. Innate and lymphocytic response of birch-allergic patients before and after sublingual immunotherapy.

Author

Guida G, Boita M, Scirelli T, Bommarito L, Heffler E, Badiu I, Bellone G, Mietta S, Mistrello G, and Rolla G

Subjects
Administration, Sublingual, Adult, Allergens administration & dosage, Antigens, Plant immunology, Coculture Techniques, Cytokines metabolism, Dendritic Cells cytology, Dendritic Cells immunology, Female, Humans, Lymphocyte Activation, Male, Middle Aged, Monocytes cytology, Monocytes immunology, Rhinitis, Allergic, Seasonal etiology, T-Lymphocytes, Regulatory immunology, Th1 Cells immunology, Treatment Outcome, Allergens immunology, Betula immunology, Desensitization, Immunologic methods, Immunity, Innate, Lymphocytes immunology, Rhinitis, Allergic, Seasonal immunology, Rhinitis, Allergic, Seasonal therapy
Abstract

Functional imbalance in Th1/Th2 cell response toward allergens is a recognized hallmark of allergic patients and a major role of dendritic cells (DCs) in redirecting T-cell phenotypes after specific immunotherapy has been suggested. This study investigates the proliferative and cytokine responses of T cells cocultured with monocyte-derived DCs (MoDCs) after allergen stimulation in birch-allergic patients compared with controls and investigates whether sublingual immunotherapy (SLIT) could change the DC-driven immune response. T cells were stimulated with the major birch pollen allergen (nBet v1) and MoDCs from eight birch-allergic patients with seasonal allergic rhinitis and eight nonallergic controls. Proliferation and cytokine production were measured before and after one course of SLIT with birch allergoid. Significantly lower levels of proinflammatory (IL-1beta, p = 0.027; IL-6, p = 0.030; TNF-alpha, p = 0.019) and Th1 (interferon gamma, p = 0.032; IL-12, p = 0.05) cytokines were measured in supernatants of T cells and MoDCs cultures from allergic patients compared with nonallergic controls. After SLIT, significant increase in IL-12 (p = 0.039), IL-1beta (p = 0.040), IL-6 (p = 0.041), TNF-α (p = 0.048), and IL-10 (p = 0.048) and significant decrease in IL-13 (p = 0.001) were observed. MoDCs/T-cell cocultures, pulsed with the specific allergen, produced lower quantities of proinflammatory and Th1 cytokines in allergic patients compared with healthy subjects, suggesting an allergen-specific impairment of natural immunity and Th1 immune response. A single course of SLIT was able to enhance allergen-specific innate immunity and to modify lymphocyte response, promoting Th1 and T-cell regulatory activity.

Published
2012
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3. Italian study on buckwheat allergy: prevalence and clinical features of buckwheat-sensitized patients in Italy

Author

A Colagiovanni, Laura Michelina Losappio, L Corradi, S Leto Barone, Sabrina Mietta, Giuseppe Guida, M.C. Turi, Stefano Pizzimenti, L Pascolini, Filippo Fassio, Enrico Tombetti, M Montagni, Iuliana Badiu, S Imbesi, L Sansone, Marco Caminati, F W Rossi, S Minetti, S Facchetti, Gianni Mistrello, Donatella Preziosi, Cristina Quecchia, Ilaria Massaro, Elisa Olivieri, Mona-Rita Yacoub, Enrico Heffler, Badiu, I, Olivieri, E, Montagni, M, Guida, G, Mietta, S, Pizzimenti, S, Caminati, M, Yacoub, Mr, Tombetti, E, Preziosi, D, Quecchia, C, Minetti, S, Facchetti, S, Fassio, F, Massaro, I, Corradi, L, Turi, Mc, Colagiovanni, A, Pascolini, L, Rossi, FRANCESCA WANDA, Losappio, L, Sansone, L, Imbesi, S, Leto Barone, S, Mistrello, G, and Heffler, E.

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Allergy, Immunology, Prevalence, medicine.disease_cause, Atopy, Young Adult, Allergen, Predictive Value of Tests, Food allergy, Environmental health, Epidemiology, medicine, Humans, Immunology and Allergy, Referral and Consultation, Sensitization, Skin Tests, Pharmacology, biology, business.industry, Fagopyrum, Female, Food Hypersensitivity, Italy, Middle Aged, Allergens, medicine.disease, biology.organism_classification, medicine.anatomical_structure, business
Abstract

Buckwheat allergy is considered a rare food allergy outside of Asia. In Europe, buckwheat has been described mainly as a hidden allergen. Data on the prevalence of buckwheat hypersensitivity in non-Asian countries is very poor. The aim of this multicenter study was to evaluate the prevalence of buckwheat sensitization and its association with other sensitizations among patients referred to allergy clinics in different geographic areas of Italy. All patients referred to 18 Italian allergy clinics from February through April 2011 were included in the study and evaluated for sensitization to buckwheat and other allergens depending on their clinical history. A total of 1,954 patients were included in the study and 61.3 percent of them were atopic. Mean prevalence of buckwheat sensitization was 3.6 percent with significant difference between Northern (4.5 percent), Central (2.2 percent) and Southern (2.8 percent) regions. This is, to our knowledge, the largest epidemiological survey on buckwheat allergy reported outside of Asia. Buckwheat is an emerging allergen in Italy, being more frequently associated to sensitization in Northern regions.

Published
2013

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