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BackgroundPreservatives are often necessary components of commercial products. Large-scale North American studies on preservative allergy are limited.ObjectiveTo evaluate demographics, positive patch test reactions (PPTRs), clinical relevance, and trends for preservatives tested by the North American Contact Dermatitis Group.MethodsWe conducted a retrospective cross-sectional analysis of North American Contact Dermatitis Group patch testing results of preservatives from 1994 through 2016.ResultsA total of 50,799 patients were tested; 11,338 (22.3%) had a PPTR to at least 1 preservative. The most frequent reactions were to methylisothiazolinone 0.2% aqueous (aq) (12.2%), formaldehyde 2% aq (7.8%), formaldehyde 1% aq (7.8%), quaternium-15 2% petrolatum (pet) (7.7%), and methyldibromo glutaronitrile/phenoxyethanol 2% pet (5.1%). Paraben mix 12% pet (1%), iodopropynyl butylcarbamate 0.1% pet (0.4%), benzyl alcohol 1% pet (0.3%), and phenoxyethanol 1% pet (0.2%) had the lowest PPTRs. Linear regression analysis of preservatives tested showed that only methylchloroisothiazolinone/methylisothiazolinone 0.01% aq (parameter estimate, 0.42; 95% CI, 0.17-0.66; P

Homemade "slime" is currently a popular childhood hobby that can cause allergic and irritant contact dermatitis. We describe a case of hand dermatitis due to homemade "slime" with a positive patch test to methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) and MI. The most common potential allergens in "slime" collected from a review of "slime" recipes found on the Internet are reviewed. Linked Content This article is linked to Jacob paper. To view this article visit https://doi.org/10.1111/pde.13810. [ABSTRACT FROM AUTHOR]

Background/Objectives Preservatives are important causes of allergic contact dermatitis. The frequency of allergy to preservatives in Australia has been unknown to date. Our objectives are to report the frequency of positive preservative patch test reactions in Australia, comparing them to the published international data, as well as exploring the current regulations in place for preservative use in Australia. Methods This was the first retrospective study of patch testing results, aggregated from four patch test clinics in three centres in Melbourne and Sydney. Results In all, 6845 patients were patch-tested during 1993-2006 and in this period the five most frequent preservative allergens were formaldehyde (4.6%), Euxyl K400 (containing methyldibromo glutaronitrile and phenoxyethanol) (3.3%), quaternium-15 (2.9%), diazolidinyl urea (2.4%), and methylchloroisothiazolinone/methylisothiazolinone (2.3%). These were followed by dimethylol dimethyl DMDM hydantoin (2.1%), chloroacetamide (2.1%) and imidazolidinyl urea (1.9%). The least frequent sensitisers were parabens (1.1%), 2-bromo-2-nitropropane-1, 3-diol (0.9%) and benzyl alcohol (0.4%). Conclusions Formaldehyde was the most prevalent preservative allergen. Chloroacetamide allergy was more commonly seen in Australia. Parabens, 2-bromo-2-nitropropane-1,3-diol and benzyl alcohol were the least frequent sensitisers. Household products in Australia are not required to list all ingredients preventing sensitised individuals from properly assessing their exposure. [ABSTRACT FROM AUTHOR]

Background: Allergic contact dermatitis is an increasingly recognized clinical problem in children. Objective: The aim of our study was to evaluate contact sensitization in patients younger than 3 years of age with suspected contact dermatitis. Methods: During a 6-year period (2002-2008), 321 children underwent routine patch testing with a screening pediatric standard series of 30 allergens. Results: Two hundred children (62.3%; 102 girls and 98 boys aged 3-36 months [mean age 27 + 5.6 months]) developed at least one positive reaction. The most frequent reactions were to nickel sulfate (26.8%), followed by potassium dichromate (9%), cocamidopropylbetaine (7.2%), cobalt chloride (6.2%), neomycin sulfate (5%), and methylchloroisothiazolinone/methylisothiazolinone (4.4%). The prevalence of contact sensitization was similar in children with (61.3%) and without (63%) atopic dermatitis. Limitations: The prevalence of contact sensitization in children younger than 3 years of age was not compared with the prevalence in older children. Conclusion: A high prevalence of contact sensitization was found in preschool children, even younger than 3 years of age. Patch testing should be considered in this age group when persistent dermatitis does not respond to conventional treatment. [Copyright &y& Elsevier]

A case study of 21-year-old non-atopic woman with face eczema was referred for allergy testing, is presented. It mentions patient's facial contact dermatitis caused by methylchloroisothiazolinone/methylisothiazolinone in a stainless steel aerosol spray. It also mentions the need of legal intervention in allergic contact dermatitis caused by MCI/MI in an occupational setting.

The article presents a case study of a 37-year old woman with an allergic reaction in both her axillae after using a new deodorant Mineral by Garnier & Co. in partnership with L'oreal Professionnel for two weeks. She had a jewelry skin intolerance history which she did not report. She was then treated with topical corticosteroids and there was a complete remission of her axillae lesions. The article discusses allergy, patch testing performed by Finn Chambers, and isothiazolinones.