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Immunologic Response, Dendritic Cell, Rhinitis, Allergic Rhinitis, Skin Testing Keywords: Immunologic Response; Dendritic Cell; Rhinitis; Allergic Rhinitis; Skin Testing EN Immunologic Response Dendritic Cell Rhinitis Allergic Rhinitis Skin Testing 1 1 1 03/02/21 20150627 NES 150627 Background Ole e 1 is one of the major allergens from olive tree pollen. Basophil activation tests (BAT) with OL and nOle e 1, along with dendritic cell (DC) maturation/proliferation studies in response to nOle e 1 stimulation, were carried out in all subjects. [Extracted from the article]

Allergic Rhinitis, Allergen Immunotherapy, Nasal Lavage, Dermatophagoides Pteronyssinus, Allergic Respiratory Disease Keywords: Allergic Rhinitis; Allergen Immunotherapy; Nasal Lavage; Dermatophagoides Pteronyssinus; Allergic Respiratory Disease EN Allergic Rhinitis Allergen Immunotherapy Nasal Lavage Dermatophagoides Pteronyssinus Allergic Respiratory Disease 1 1 1 03/02/21 20150627 NES 150627 Background Allergen immunotherapy (AIT) is the etiologic treatment of the allergic respiratory disease and has the ability to modify their natural course. [Extracted from the article]

Background: The measurement of nasal specific IgE (NsIgE) in local allergic rhinitis (LAR) patients is challenging and shows variability. The objective of this work was to evaluate a minimally‐invasive method of direct detection of NsIgE in patients with LAR to Dermatophagoides pteronyssinus (DP) using an automated immunoassay. Methods: Fifty patients participated (LAR, n = 14; allergic rhinitis (AR), n = 20; healthy controls [HC], n = 16). Detection of NsIgE was performed by direct application of the solid phase of a commercial DP ImmunoCAP® test 24 hours after DP nasal provocation. Results: There was no difference in the median volume of secretion absorbed by the solid phase of the ImmunoCAP test in the 3 studied groups (p = 0.17). According to receiver operating characteristic (ROC) curve analysis, NsIgE ≥0.1450 was the optimal cutoff point, obtaining in LAR patients 42.86% sensitivity with the highest specificity (100%), and 75% sensitivity and 100% specificity for AR. Conclusion: This study demonstrates the detection of NsIgE to DP in LAR by using a simple, commercial device with high specificity. [ABSTRACT FROM AUTHOR]