1. Penaeus monodon tropomyosin induces CD4 T-cell proliferation in shrimp-allergic patients
- Author
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Wang, Shuping, Delgado, Julio C., Ravkov, Eugene, Eckels, David D., Georgelas, Ann, Pavlov, Igor Y., Cusick, Matthew, Sebastian, Kate, Gleich, Gerald J., and Wagner, Lori A.
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PENAEUS monodon , *TROPOMYOSINS , *ALLERGIES , *CYTOTOXIC T cells , *CELL proliferation , *SHELLFISH , *IMMUNOLOGIC diseases - Abstract
Abstract: Shellfish allergy affects approximately 2% of the population and can cause immediate hypersensitivity reactions such as urticaria, swelling, difficulty breathing, and, in some cases, anaphylaxis. Tropomyosin is the major shrimp allergen and binds IgE in two-thirds of patients. A total of 38 shrimp-allergic patients and 20 negative control subjects were recruited and evaluated on the basis of history, skin prick testing, specific immunoglobulin E (IgE) levels, and peripheral blood mononuclear cell proliferation in response to shrimp tropomyosin or shrimp tropomyosin–derived peptides. Of the classically allergic patients by history, 59% tested positive for serum shrimp IgE antibodies. Of patients with shrimp-specific IgE in sera, 70% also had significant IgE levels specific for shrimp tropomyosin. Peripheral blood mononuclear cells from classically shrimp-allergic patients proliferated in a dose-dependent manner in response to to tropomyosin. In addition, a T-cell line derived from a shrimp-allergic patient proliferated specifically in response to tropomyosin-derived peptides. These studies suggest a strategy for immunotherapy using a tropomyosin-derived T-cell epitope vaccination. [Copyright &y& Elsevier]
- Published
- 2012
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