23 results on '"Comberiati, Pasquale"'
Search Results
2. SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children
- Author
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Caffarelli, Carlo, Franceschini, Fabrizio, Caimmi, Davide, Mori, Francesca, Diaferio, Lucia, Di Mauro, Dora, Mastrorilli, Carla, Arasi, Stefania, Barni, Simona, Bottau, Paolo, Caimmi, Silvia, Cardinale, Fabio, Comberiati, Pasquale, Crisafulli, Giuseppe, Liotti, Lucia, Pelosi, Umberto, Saretta, Francesca, Marseglia, Gianluigi, Duse, Marzia, and Paravati, Francesco
- Published
- 2018
- Full Text
- View/download PDF
3. 'Too high, too low': the complexities of using thresholds in isolation to inform precautionary allergen ('may contain') labels
- Author
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Turner, Paul J, Baumert, Joseph L, Beyer, Kirsten, Brooke-Taylor, Simon, Comberiati, Pasquale, Crevel, René W R, Gerdts, Jennifer D, Gowland, M Hazel, Houben, Geert F, Hourihane, Jonathan O'B, Konstantinou, George N, La Vieille, Sébastien, Moya, Beatriz, Muraro, Antonella, Mills, E N Clare, Patel, Nandinee, Podestà, Marcia, Popping, Bert, Reese, Imke, Roberts, Graham, Said, Maria, Santos, Alexandra F, Schnadt, Sabine, Taylor, Steve L, Vlieg-Boerstra, Berber, and Remington, Benjamin C
- Subjects
Anaphylaxis ,eliciting dose ,food allergy ,precautionary allergen labelling ,reference dose, thresholds ,Allergy ,EAACI Taskforce on Food allergen thresholds ,Immunology ,thresholds ,reference dose ,Allergens ,Food Labeling ,1107 Immunology ,Immunology and Allergy ,Humans ,Food Hypersensitivity - Published
- 2021
4. A practical toolbox for the effective transition of adolescents and young adults with asthma and allergies: An EAACI position paper.
- Author
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Vazquez‐Ortiz, Marta, Gore, Claudia, Alviani, Cherry, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Garriga‐Baraut, Teresa, Gowland, M. Hazel, Egmose, Britt, Knibb, Rebecca, Khaleva, Ekaterina, Mortz, Charlotte G., Pfaar, Oliver, Pite, Helena, Podesta, Marcia, Santos, Alexandra F., Sanchez‐Garcia, Silvia, and Timmermans, Frans
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YOUNG adults ,ALLERGIES ,MEDICAL personnel ,ASTHMA ,TEENAGERS - Abstract
Introduction: Adolescence is a critical stage of rapid biological, emotional and social change and development. Adolescents and young adults (AYA) with asthma and allergies need to develop the knowledge and skills to self‐manage their health independently. Healthcare professionals (HCP), parents and their wider network play an essential role in supporting AYA in this process. Previous work showed significant limitations in transition care across Europe. In 2020, the first evidence‐based guideline on effective transition for AYA with asthma and allergies was published by EAACI. Aim: We herein summarize practical resources to support this guideline's implementation in clinical practice. Methods: For this purpose, multi‐stakeholder Task Force members searched for resources in peer review journals and grey literature. These resources were included if relevant and of good quality and were pragmatically rated for their evidence‐basis and user friendliness. Results: Resources identified covered a range of topics and targeted healthcare professionals, AYA, parents/carers, schools, workplace and wider community. Most resources were in English, web‐based and had limited evidence‐basis. Conclusions: This position paper provides a valuable selection of practical resources for all stakeholders to support effective transitional care for AYA with asthma and allergies. Future research should focus on developing validated, patient‐centred tools to further assist evidence‐based transition care. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Current transition management of adolescents and young adults with allergy and asthma
- Author
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Khaleva, Ekaterina, Vazquez-Ortiz, Marta, Comberiati, Pasquale, Dunngalvin, Audrey, Pite, Helena, Blumchen, Katharina, Garriga-Baraut, Teresa, Hox, Valerie, Santos, Alexandra F., Gore, Claudia, Knibb, Rebecca C., Alviani, Cherry, Mortz, Charlotte G., Angier, Elizabeth, Duca, Bettina, Jensen, Britt, Sanchez-Garcia, Silvia, Gowland, M. Hazel, Timmermans, Frans, Pfaar, Oliver, Roberts, Graham, Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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Pulmonary and Respiratory Medicine ,Healthcare professional ,Young adult ,Adolescent ,Allergy ,SDG 3 - Good Health and Well-being ,education ,Transition ,Immunology ,Immunology and Allergy ,humanities - Abstract
Background: Transition from parent-delivered to self-management is a vulnerable time for adolescents and young adults (AYA) with allergy and asthma. There is currently no European guideline available for healthcare professionals (HCPs) on transition of these patients and local/national protocols are also mostly lacking. Methods: European HCPs working with AYA with allergy and asthma were invited to complete an online survey assessing challenges of working with these patients, current transition practices and access to specific healthcare resources. Results: A total of 1179 responses from 41 European countries were collected. Most HCPs (86%) reported a lack of a transition guideline and a lack of a transition process (20% paediatric HCPs, 50% of adult HCPs, 56% HCP seeing all ages). Nearly half (48%) acknowledged a lack of an established feedback system between paediatric and adult medical services. Many respondents never routinely asked about mental health issues such as self-harm or depression and are not confident in asking about self-harm (66.6%), sexuality (64%) and depression (43.6%). The majority of HCPs (76%) had not received specific training in the care of AYA although 87% agreed that transition was important for AYA with allergy and asthma. Conclusion: Although there was agreement that transition is important for AYA with allergy and asthma, there are crucial limitations and variations in the current provision of transition services across Europe. Standardisation of AYA management and specific training are required. This should improve management and continuity of care during adolescence and into adulthood to achieve the best healthcare outcomes.[Figure not available: See fulltext.] publishersversion published
- Published
- 2020
6. A systematic review
- Author
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Vazquez-Ortiz, Marta, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Gore, Claudia, Hox, Valérie, Jensen, Britt, Pite, Helena, Santos, Alexandra F., Sanchez, Silvia, Alviani, Cherry, Garriga-Baraut, Teresa, Knibb, Rebecca, Mortz, Charlotte G., Gowland, M. Hazel, Timmermans, Frans, Roberts, Graham, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)
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food allergy ,SDG 3 - Good Health and Well-being ,adolescent ,Immunology ,rhinoconjunctivitis ,transition ,young adult ,Immunology and Allergy ,asthma ,allergy - Abstract
Background: Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions. Methods: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative meta-synthesis was undertaken. Results: A total of 108 papers describing 106 studies were retrieved, most focused on asthma. Five themes were identified across studies: (a) Health-related quality of life—impairment was associated with poor disease control, psychosocial issues, adolescent-onset allergic disease and female sex; (b) Psychological factors—asthma and food allergy were associated with anxiety and depression, atopic dermatitis was associated with suicidal ideation, and that parental emotional support may be protective; (c) Adherence—suboptimal adherence was associated with older age, barriers to medication usage, poor symptom perception and failure to take responsibility, and positive factors were routines, simpler treatment regimes, better knowledge and perceptions about medications; (d) Self-management—facilitated by education, knowledge and a positive attitude; and (e) Supportive relationships—families could modify barriers to adherence and foster positive views about self-management, adolescents suggested that their peers should be more involved in supporting them, and adolescents also wished to have support from nonjudgemental healthcare professionals. Conclusions: We have some understanding of the challenges faced by adolescents with asthma, less so for other allergic conditions. This knowledge will be used to support guidelines for managing adolescents. publishersversion published
- Published
- 2020
7. A systematic review
- Author
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Knibb, Rebecca C., Alviani, Cherry, Garriga-Baraut, Teresa, Mortz, Charlotte G., Vazquez-Ortiz, Marta, Angier, Elizabeth, Blumchen, Katerina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Gore, Claudia, Hox, Valerie, Jensen, Britt, Pite, Helena, Santos, Alexandra F., Sanchez-Garcia, Silvia, Gowland, M. Hazel, Timmermans, Frans, Roberts, Graham, Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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adolescent ,Immunology ,young adult ,Immunology and Allergy ,asthma ,allergy ,interventions - Abstract
Background: This systematic review aimed to review the literature on interventions for improving self-management and well-being in adolescents and young adults (11-25 years) with asthma and allergic conditions. Methods: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative synthesis was undertaken. Results: A total of 30 papers reporting data from 27 studies were included. Interventions types were psychological (k = 9); e-health (k = 8); educational (k = 4); peer-led (k = 5); breathing re-training (k = 1). All interventions were for asthma. Psychological interventions resulted in significant improvements in the intervention group compared with the control group for self-esteem, quality of life, self-efficacy, coping strategies, mood and asthma symptoms. E-Health interventions reported significant improvements for inhaler technique, adherence and quality of life. General educational interventions demonstrated significantly improved quality of life, management of asthma symptoms, controller medication use, increased use of a written management plan and reduction in symptoms. The peer-led interventions included the Triple A (Adolescent Asthma Action) programme and a peer-led camp based on the Power Breathing Programme. Improvements were found for self-efficacy, school absenteeism and quality of life. Conclusion: Although significant improvements were seen for all intervention types, many were small feasibility or pilot studies, few studies reported effect sizes and no studies for allergic conditions other than asthma met the inclusion criteria. Research using large longitudinal interventional designs across the range of allergic conditions is required to strengthen the evidence base. publishersversion published
- Published
- 2020
8. A compendium answering 150 questions on COVID-19 and SARS-CoV-2
- Author
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Riggioni, Carmen, Comberiati, Pasquale, Giovannini, Mattia, Agache, Ioana, Akdis, Muebeccel, Alves-Correia, Magna, Anto, Josep M., and KKÜ
- Subjects
coronavirus disease 2019 ,SARS-CoV-2 ,COVID-19 ,severe acute respiratory syndrome-related coronavirus 2 ,allergy - Abstract
Jimenez-Saiz, Rodrigo/0000-0002-0606-3251; O'Mahony, Liam/0000-0003-4705-3583; Comberiati, Pasquale/0000-0001-5209-9733; O'Hehir, Robyn/0000-0002-3489-7595; de las Vecillas Sanchez, Leticia/0000-0003-4969-5678; RIGGIONI, CARMEN/0000-0002-8745-0228; Correia, Magna/0000-0002-7676-5558; AZKUR, DILEK/0000-0002-4396-9087 WOS:000550399700001 PubMed: 32535955 In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in similar to 9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease. EAACI The authors thank EAACI for the support to the Junior Member Assembly (JMA), the sections, interest groups, and working groups that enabled the generation of this paper. The authors recognize Dr Anna Globinska for graphic design and Dr Laura Alberch for a critical review of the manuscript.
- Published
- 2020
9. IgE to cyclophilins in pollen-allergic children: Epidemiologic, clinical, and diagnostic relevance of a neglected panallergen.
- Author
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Matricardi, Paolo Maria, Potapova, Ekaterina, Panetta, Valentina, Lidholm, Jonas, Mattsson, Lars, Scala, Enrico, Bernardini, Roberto, Caffarelli, Carlo, Casani, Antonella, Cervone, Rosa, Chini, Loredana, Comberiati, Pasquale, De Castro, Giovanna, Miraglia del Giudice, Michele, Dello Iacono, Iride, Di Rienzo Businco, Andrea, Gallucci, Marcella, Giannetti, Arianna, Moschese, Viviana, and Varin, Elena
- Abstract
[Display omitted] Cyclophilins are ubiquitous panallergens whose epidemiologic, diagnostic, and clinical relevance is largely unknown and whose sensitization is rarely examined in routine allergy practice. We investigated the epidemiologic, diagnostic, and clinical relevance of cyclophilins in seasonal allergic rhinitis and its comorbidities. We examined a random sample of 253 (25%) of 1263 Italian children with seasonal allergic rhinitis from the Panallergens in Pediatrics (PAN-PED) cohort with characterized disease phenotypes. Nested studies of sensitization prevalence, correlation, and allergen extract inhibition were performed in patients sensitized to birch pollen extract but lacking IgE to Bet v 1/2/4 (74/1263) or with highest serum level of IgE to Bet v 1 (26/1263); and in patients with sensitization to various extracts (ragweed, mugwort, pellitory, Plantago , and plane tree), but not to their respective major allergenic molecule, profilins, and polcalcins. IgE to cyclophilin was detected with recombinant Bet v 7, and extract inhibition tests were performed with the same rBet v 7. IgE to rBet v 7 was detected in 43 (17%) of 253 patients. It was associated with asthma (P <.028) and oral allergy syndrome (P <.017) in univariate but not multivariate analysis adjusted for IgE to profilins (Phl p 12), PR-10s (Bet v 1), and lipid transfer proteins (Pru p 3). IgE to rBet v 7 was also highly prevalent (47/74, 63%) among patients with unexplained sensitization to birch pollen extract. In patients with unexplained sensitization to ragweed, mugwort, pellitory, Plantago and plane tree pollen, the levels of IgE to those extracts correlated with the levels of IgE to rBet v 7, and they were also significantly inhibited by rBet v 7 (inhibition range 45%-74%). IgE sensitization to cyclophilin is frequent in pollen-allergic patients living in temperate areas and can produce "false" positive outcomes in skin prick and IgE tests to pollen extracts. Molecular diagnostic guidelines should include this panallergen family. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. Perceptions of adolescents and young adults with allergy and/or asthma and their parents on EAACI guideline recommendations about transitional care: A European survey.
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Khaleva, Ekaterina, Knibb, Rebecca, DunnGalvin, Audrey, Vazquez‐Ortiz, Marta, Comberiati, Pasquale, Alviani, Cherry, Garriga‐Baraut, Teresa, Gowland, Mary Hazel, Gore, Claudia, Angier, Elizabeth, Blumchen, Katharina, Duca, Bettina, Hox, Valérie, Jensen, Britt, Mortz, Charlotte G., Pite, Helena, Pfaar, Oliver, Santos, Alexandra F., Sanchez‐Garcia, Silvia, and Timmermans, Frans
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YOUNG adults ,TRANSITIONAL care ,MEDICAL personnel ,PARENTS ,ASTHMATICS - Abstract
Background: The European Academy of Allergy and Clinical Immunology has developed a guideline to provide evidence‐based recommendations for healthcare professionals to support the transitional care of adolescents and young adults (AYA) with allergy and/or asthma. The goal of this work was to ensure that the draft recommendations are also important for patients. Methods: We surveyed patients aged 11–25 years with allergy and/or asthma and their parents across Europe between 17 February and 16 March 2020. The multilingual survey was distributed through national allergy and asthma patient organizations in Europe as well as through social media. Results: A total of 1210 responses from 24 European countries were collected. There were 415 (34.3%) AYA and 795 (65.7%) parents. The majority of AYA (72.3%) and parents (81.9%) were female. Patients had a history of asthma (61.1%), allergic rhinoconjunctivitis (54.1%), food allergy (53.8%), atopic eczema (42.6%) and anaphylaxis (28.8%). All recommendations achieved the median score of either 'important' or 'very important'. The least supported recommendations were the use of joint clinics with both paediatric and adult physicians attending and the use of web‐based or mobile technologies for communication with the AYA. The most supported recommendation was checking that the AYA is knowledgeable and compliant with their prescribed medication. Qualitative analysis revealed conditional approval for some recommendations. Conclusions: There was agreement from patients and parents on the importance of the draft recommendations on transitional care for AYA with allergy and/or asthma and their parents. The recommendations now need to be implemented into clinical practice across Europe. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
11. Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report
- Author
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Pajno, Gb, Bernardini, R, Peroni, Diego, Arasi, S, Martelli, Arianna, Landi, M, Passalacqua, G, Muraro, Alessandra, La Grutta, S, Fiocchi, A, Indinnimeo, L, Caffarelli, C, Calamelli, E, Comberiati, Pasquale, Duse, M, Akdis, C, Akdis, M, Arrigoni, Sara, Barberi, S, Baviera, G, Boner, Attilio, Calvani, M, Calzone, L, Caminiti, L, Capristo, A, Capristo, C, Chiera, F, Cravidi, C, Crisafulli, G, De Castro, G, DE SIMONE, Martina, Dello Iacono, I, Dondi, A, Galli, Enrico, Guglielmo, F, Maiello, N, Marseglia, G, Matricardi, Pm, Meglio, P, Minasi, D, Del Giudice, Mm, Panasci, G, Paravati, F, Pelosi, U, Pingitore, G, Ricci, G, Scala, G, Terracciano, L, Tosca, M, Tripodi, S, Verga, Mc, Wahn, U., Pajno, Giovanni Battista, Bernardini, Roberto, Peroni, Diego, Arasi, Stefania, Martelli, Alberto, Landi, Massimo, Passalacqua, Giovanni, Muraro, Antonella, La Grutta, Stefania, Fiocchi, Alessandro, Indinnimeo, Luciana, Caffarelli, Carlo, Calamelli, Elisabetta, Comberiati, Pasquale, and Duse, Marzia
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Pediatrics ,Allergy ,medicine.medical_treatment ,Administration, Oral ,Dermatitis ,Review ,Desensitization ,0302 clinical medicine ,Immunologic ,030212 general & internal medicine ,Child ,Children ,Societies, Medical ,Randomized Controlled Trials as Topic ,Clinical Trials as Topic ,Subcutaneous immunotherapy ,Subcutaneous ,Atopic dermatitis ,Perinatology and Child Health ,Atopic dermatiti ,Clinical Practice ,Treatment Outcome ,allergen-specific immunotherapy ,allergy ,asthma ,atopic dermatitis ,children ,food allergy ,sub-lingual immunotherapy ,subcutaneous immunotherapy ,pediatrics, perinatology and child health ,Italy ,Administration ,Practice Guidelines as Topic ,Sub-lingual immunotherapy ,Food Hypersensitivity ,Oral ,medicine.medical_specialty ,Consensus ,Injections, Subcutaneous ,Atopic ,Dermatitis, Atopic ,Injections ,03 medical and health sciences ,Pharmacotherapy ,Food allergy ,Medical ,medicine ,Humans ,Medical prescription ,Asthma ,Allergen-specific immunotherapy ,business.industry ,Immunotherapy ,medicine.disease ,030228 respiratory system ,Desensitization, Immunologic ,Pediatrics, Perinatology and Child Health ,Societies ,business - Abstract
Allergen-specific immunotherapy (AIT) is currently recognized as a clinically effective treatment for allergic diseases, with a unique disease-modifying effect. AIT was introduced in clinical practice one century ago, and performed in the early years with allergenic extracts of poor quality and definition. After the mechanism of allergic reaction were recognized, the practice of AIT was refined, leading to remarkable improvement in the efficacy and safety profile of the treatment. Currently AIT is accepted and routinely prescribed worldwide for respiratory allergies and hymenoptera venom allergy. Both the subcutaneous (SCIT) and sublingual (SLIT) routes of administration are used in the pediatric population. AIT is recommended in allergic rhinitis/conjunctivitis with/without allergic asthma, with an evidence of specific IgE-sensitization towards clinically relevant inhalant allergens. Long-term studies provided evidence that AIT can also prevent the onset of asthma and of new sensitizations. The favorable response to AIT is strictly linked to adherence to treatment, that lasts 3–5 years. Therefore, several factors should be carefully evaluated before starting this intervention, including the severity of symptoms, pharmacotherapy requirements and children and caregivers’ preference and compliance. In recent years, there have been increasing interest in the role of AIT for the treatment of IgE-associated food allergy and extrinsic atopic dermatitis. A growing body of evidence shows that oral immunotherapy represents a promising treatment option for IgE-associated food allergy. On the contrary, there are still controversies on the effectiveness of AIT for patients with atopic dermatitis. This consensus document was promoted by the Italian Society of Pediatric Allergy and Immunology (SIAIP) to provide evidence-based recommendations on AIT in order to implement and optimize current prescription practices of this treatment for allergic children.
- Published
- 2017
12. EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma.
- Author
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Roberts, Graham, Vazquez‐Ortiz, Marta, Knibb, Rebecca, Khaleva, Ekaterina, Alviani, Cherry, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Garriga‐Baraut, Teresa, Gore, Claudia, Gowland, M. Hazel, Hox, Valérie, Jensen, Britt, Mortz, Charlotte G., Pfaar, Oliver, Pite, Helena, Santos, Alexandra F., and Sanchez‐Garcia, Silvia
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YOUNG adults ,MEDICAL personnel ,TEENAGERS ,TRANSITIONAL care ,ASTHMA ,ALLERGIES - Abstract
Adolescent and young adult (AYA) patients need additional support, while they experience the challenges associated with their age. They need specific training to learn the knowledge and skills required to confidently self‐manage their allergies and/or asthma. Transitional care is a complex process, which should address the psychological, medical, educational and vocational needs of AYA in the developmentally appropriate way. The European Academy of Allergy and Clinical Immunology has developed a clinical practice guideline to provide evidence‐based recommendations for healthcare professionals to support the transitional care of AYA with allergy and/or asthma. This guideline was developed by a multidisciplinary working panel of experts and patient representatives based on two recent systematic reviews. It sets out a series of general recommendations on operating a clinical service for AYA, which include the following: (a) starting transition early (11‐13 years), (b) using a structured, multidisciplinary approach, (c) ensuring AYA fully understand their condition and have resources they can access, (d) active monitoring of adherence and (e) discussing any implications for further education and work. Specific allergy and asthma transition recommendations include (a) simplifying medication regimes and using reminders; (b) focusing on areas where AYA are not confident and involving peers in training AYA patients; (c) identifying and managing psychological and socio‐economic issues impacting disease control and quality of life; (d) enrolling the family in assisting AYA to undertake self‐management; and (e) encouraging AYA to let their friends know about their allergies and asthma. These recommendations may need to be adapted to fit into national healthcare systems. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
13. The effectiveness of interventions to improve self‐management for adolescents and young adults with allergic conditions: A systematic review.
- Author
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Knibb, Rebecca C., Alviani, Cherry, Garriga‐Baraut, Teresa, Mortz, Charlotte G., Vazquez‐Ortiz, Marta, Angier, Elizabeth, Blumchen, Katerina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Gore, Claudia, Hox, Valerie, Jensen, Britt, Pite, Helena, Santos, Alexandra F., Sanchez‐Garcia, Silvia, Gowland, M. Hazel, Timmermans, Frans, and Roberts, Graham
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YOUNG adults ,TEENAGERS ,META-analysis ,SCHOOL absenteeism ,PSYCHOLOGICAL typologies ,ALLERGIC conjunctivitis - Abstract
Background: This systematic review aimed to review the literature on interventions for improving self‐management and well‐being in adolescents and young adults (11‐25 years) with asthma and allergic conditions. Methods: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative synthesis was undertaken. Results: A total of 30 papers reporting data from 27 studies were included. Interventions types were psychological (k = 9); e‐health (k = 8); educational (k = 4); peer‐led (k = 5); breathing re‐training (k = 1). All interventions were for asthma. Psychological interventions resulted in significant improvements in the intervention group compared with the control group for self‐esteem, quality of life, self‐efficacy, coping strategies, mood and asthma symptoms. E‐Health interventions reported significant improvements for inhaler technique, adherence and quality of life. General educational interventions demonstrated significantly improved quality of life, management of asthma symptoms, controller medication use, increased use of a written management plan and reduction in symptoms. The peer‐led interventions included the Triple A (Adolescent Asthma Action) programme and a peer‐led camp based on the Power Breathing Programme. Improvements were found for self‐efficacy, school absenteeism and quality of life. Conclusion: Although significant improvements were seen for all intervention types, many were small feasibility or pilot studies, few studies reported effect sizes and no studies for allergic conditions other than asthma met the inclusion criteria. Research using large longitudinal interventional designs across the range of allergic conditions is required to strengthen the evidence base. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
14. Understanding the challenges faced by adolescents and young adults with allergic conditions: A systematic review.
- Author
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Vazquez‐Ortiz, Marta, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Gore, Claudia, Hox, Valérie, Jensen, Britt, Pite, Helena, Santos, Alexandra F., Sanchez, Silvia, Alviani, Cherry, Garriga‐Baraut, Teresa, Knibb, Rebecca, Mortz, Charlotte G., Gowland, M. Hazel, Timmermans, Frans, and Roberts, Graham
- Subjects
YOUNG adults ,TEENAGERS ,ADOLESCENCE ,QUALITY of life ,MEDICAL personnel ,ATTITUDES toward sex - Abstract
Background: Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions. Methods: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative meta‐synthesis was undertaken. Results: A total of 108 papers describing 106 studies were retrieved, most focused on asthma. Five themes were identified across studies: (a) Health‐related quality of life—impairment was associated with poor disease control, psychosocial issues, adolescent‐onset allergic disease and female sex; (b) Psychological factors—asthma and food allergy were associated with anxiety and depression, atopic dermatitis was associated with suicidal ideation, and that parental emotional support may be protective; (c) Adherence—suboptimal adherence was associated with older age, barriers to medication usage, poor symptom perception and failure to take responsibility, and positive factors were routines, simpler treatment regimes, better knowledge and perceptions about medications; (d) Self‐management—facilitated by education, knowledge and a positive attitude; and (e) Supportive relationships—families could modify barriers to adherence and foster positive views about self‐management, adolescents suggested that their peers should be more involved in supporting them, and adolescents also wished to have support from nonjudgemental healthcare professionals. Conclusions: We have some understanding of the challenges faced by adolescents with asthma, less so for other allergic conditions. This knowledge will be used to support guidelines for managing adolescents. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
15. EAACI Allergen Immunotherapy User's Guide.
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Alvaro‐Lozano, Montserrat, Akdis, Cezmi A., Akdis, Mubeccel, Alviani, Cherry, Angier, Elisabeth, Arasi, Stefania, Arzt‐Gradwohl, Lisa, Barber, Domingo, Bazire, Raphaëlle, Cavkaytar, Ozlem, Comberiati, Pasquale, Dramburg, Stephanie, Durham, Stephen R., Eifan, Aarif O., Forchert, Leandra, Halken, Susanne, Kirtland, Max, Kucuksezer, Umut C., Layhadi, Janice A., and Matricardi, Paolo Maria
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IMMUNOTHERAPY ,SUBLINGUAL immunotherapy ,ALLERGENS ,SUPPRESSOR cells ,PATIENT compliance ,MEDICAL personnel ,RESPIRATORY allergy - Abstract
Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and downplaying the immune response induced by allergens. Clinical indications have been well documented for respiratory allergy in the presence of rhinitis and/or allergic asthma, to pollens and dust mites. Patients who have had an anaphylactic reaction to hymenoptera venom are also good candidates for allergen immunotherapy. Administration of allergen is currently mostly either by subcutaneous injections or by sublingual administration. Both methods have been extensively studied and have pros and cons. Specifically in children, the choice of the method of administration according to the patient's profile is important. Although allergen immunotherapy is widely used, there is a need for improvement. More particularly, biomarkers for prediction of the success of the treatments are needed. The strength and efficiency of the immune response may also be boosted by the use of better adjuvants. Finally, novel formulations might be more efficient and might improve the patient's adherence to the treatment. This user's guide reviews current knowledge and aims to provide clinical guidance to healthcare professionals taking care of children undergoing allergen immunotherapy. [ABSTRACT FROM AUTHOR]
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- 2020
- Full Text
- View/download PDF
16. Microbiome Composition and Its Impact on the Development of Allergic Diseases.
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Peroni, Diego G., Nuzzi, Giulia, Trambusti, Irene, Di Cicco, Maria Elisa, and Comberiati, Pasquale
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ALLERGIES ,FOOD allergy ,ATOPIC dermatitis ,HUMAN microbiota ,THERAPEUTICS - Abstract
Allergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported over the last few years has closely paralleled substantial environmental changes both on a macro and micro scale, which have led to reduced microbial exposure in early life and perturbation of the human microbiome composition. Increasing evidence shows that early life interactions between the human microbiome and the immune cells play a pivotal role in the development of the immune system. Therefore, the process of early colonization by a "healthy" microbiome is emerging as a key determinant of life-long health. In stark contrast, the perturbation of such a process, which results in changes in the host-microbiome biodiversity and metabolic activities, has been associated with greater susceptibility to immune-mediated disorders later in life, including allergic diseases. Here, we outline recent findings on the potential contribution of the microbiome in the gastrointestinal tract, skin, and airways to the development of FA, AD, and asthma. Furthermore, we address how the modulation of the microbiome composition in these different body districts could be a potential strategy for the prevention and treatment of allergic diseases. [ABSTRACT FROM AUTHOR]
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- 2020
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17. The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever
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Stringari, Giovanna, Tripodi, Salvatore, Caffarelli, Carlo, Dondi, Arianna, Asero, Riccardo, Businco Andrea Di Rienzo, Bianchi, Annamaria, Candelotti, Paolo, Ricci, Giampaolo, Bellini, Federica, Maiello, Nunzia, Giudice Michele Miraglia del, Frediani, Tullio, Sodano, Simona, Iacono Iride Dello, Macrì, Francesco, Peparini, Ilaria, Dascola Carlotta Povesi, Patria Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Matricardi Paolo Maria, Network The Italian Pediatric Allergy, Stringari, Giovanna, Tripodi, Salvatore, Caffarelli, Carlo, Dondi, Arianna, Asero, Riccardo, Di Rienzo Businco, Andrea, Bianchi, Annamaria, Candelotti, Paolo, Ricci, Giampaolo, Bellini, Federica, Maiello, Nunzia, Miraglia Del Giudice, Michele, Frediani, Tullio, Sodano, Simona, Dello Iacono, Iride, Macrì, Francesco, Peparini, Ilaria, Povesi Dascola, Carlotta, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Matricardi, Paolo Maria, and MIRAGLIA DEL GIUDICE, Michele
- Subjects
Male ,Allergy ,component-resolved diagnosis ,Profilin ,Gene Expression ,Immunoglobulin E ,Allergic rhinitis ,Profilins ,Mugwort ,Outpatient clinic ,Immunology and Allergy ,Child ,Sensitization ,panallergens ,biology ,Skin Test ,Allergen ,Medicine (all) ,Plants ,medicine.anatomical_structure ,panallergen ,pollen ,Child, Preschool ,Hay fever ,Cross Reaction ,Female ,IgE ,Allergic rhinitis, children, component-resolved diagnosis, IgE, panallergens, pollen, profilin, specific immunotherapy ,specific immunotherapy ,Human ,medicine.medical_specialty ,Adolescent ,Immunology ,Cross Reactions ,component-resolved diagnosi ,NO ,children ,Internal medicine ,medicine ,Allergic rhiniti ,Humans ,Medical prescription ,Skin Tests ,Settore MED/38 - Pediatria Generale e Specialistica ,business.industry ,Rhinitis, Allergic, Seasonal ,Plant ,Allergens ,medicine.disease ,Desensitization, Immunologic ,biology.protein ,Allergists ,profilin ,business - Abstract
Background Sensitization to profilins and other cross-reacting molecules might hinder proper specific immunotherapy (SIT) prescription in polysensitized patients with pollen-related allergic rhinitis (AR). In these patients, component-resolved diagnosis (CRD) might modify SIT prescription by improving the identification of the disease-eliciting pollen sources. Objectives We sought to measure the effect of CRD on SIT prescription in children with pollen-related AR. Methods Children (n = 651) with moderate-to-severe pollen-related AR were recruited between May 2009 and June 2011 in 16 Italian outpatient clinics. Skin prick test (SPT) reactivity to grass, cypress, olive, mugwort, pellitory, and/or Betulaceae pollen was considered clinically relevant if symptoms occurred during the corresponding peak pollen season. IgE sensitization to Phl p 1, Phl p 5, Bet v 1, Cup a 1, Art v 1, Ole e 1, Par j 2, and Phl p 12 (profilin) was measured by using ImmunoCAP. SIT prescription was modeled on SPT responses first and then remodeled considering also CRD according to GA2LEN-European Academy of Allergology and Clinical Immunology guidelines and the opinions of 14 pediatric allergists. Results No IgE to the respective major allergens was detected in significant proportions of patients with supposed clinically relevant sensitization to mugwort (45/65 [69%]), Betulaceae (146/252 [60%]), pellitory (78/257 [30%]), olive (111/390 [28%]), cypress (28/184 [15%]), and grass (56/568 [10%]). IgE to profilins, polcalcins, or both could justify 173 (37%) of 464 of these SPT reactions. After CRD, the SPT-based decision on SIT prescription or composition was changed in 277 (42%) of 651 or 315 (48%) of 651 children according to the European or American approach, respectively, and in 305 (47%) of 651 children according to the opinion of the 14 local pediatric allergists. Conclusions In children with pollen-related AR, applying CRD leads to changes in a large proportion of SIT prescriptions as opposed to relying on clinical history and SPT alone. The hypothesis that CRD-guided prescription improves SIT efficacy deserves to be tested. © 2014 American Academy of Allergy, Asthma and Immunology.
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- 2014
18. Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report.
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Battista Pajno, Giovanni, Bernardini, Roberto, Peroni, Diego, Arasi, Stefania, Martelli, Alberto, Landi, Massimo, Passalacqua, Giovanni, Muraro, Antonella, La Grutta, Stefania, Fiocchi, Alessandro, Indinnimeo, Luciana, Caffarelli, Carlo, Calamelli, Elisabetta, Comberiati, Pasquale, and Duse, Marzia
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ALLERGY treatment ,ATOPIC dermatitis treatment ,FOOD allergy ,RESPIRATORY allergy ,ALLERGENS ,ALLERGY desensitization ,CONSENSUS (Social sciences) ,IMMUNOGLOBULINS ,MEDICAL protocols ,PATIENT compliance ,PEDIATRICS ,TREATMENT duration ,SUBLINGUAL immunotherapy ,CHILDREN - Abstract
Allergen-specific immunotherapy (AIT) is currently recognized as a clinically effective treatment for allergic diseases, with a unique disease-modifying effect. AIT was introduced in clinical practice one century ago, and performed in the early years with allergenic extracts of poor quality and definition. After the mechanism of allergic reaction were recognized, the practice of AIT was refined, leading to remarkable improvement in the efficacy and safety profile of the treatment. Currently AIT is accepted and routinely prescribed worldwide for respiratory allergies and hymenoptera venom allergy. Both the subcutaneous (SCIT) and sublingual (SLIT) routes of administration are used in the pediatric population. AIT is recommended in allergic rhinitis/conjunctivitis with/without allergic asthma, with an evidence of specific IgE-sensitization towards clinically relevant inhalant allergens. Long-term studies provided evidence that AIT can also prevent the onset of asthma and of new sensitizations. The favorable response to AIT is strictly linked to adherence to treatment, that lasts 3-5 years. Therefore, several factors should be carefully evaluated before starting this intervention, including the severity of symptoms, pharmacotherapy requirements and children and caregivers' preference and compliance. In recent years, there have been increasing interest in the role of AIT for the treatment of IgE-associated food allergy and extrinsic atopic dermatitis. A growing body of evidence shows that oral immunotherapy represents a promising treatment option for IgE-associated food allergy. On the contrary, there are still controversies on the effectiveness of AIT for patients with atopic dermatitis. This consensus document was promoted by the Italian Society of Pediatric Allergy and Immunology (SIAIP) to provide evidence-based recommendations on AIT in order to implement and optimize current prescription practices of this treatment for allergic children. [ABSTRACT FROM AUTHOR]
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- 2017
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19. Cow's Milk Substitutes for Children: Nutritional Aspects of Milk from Different Mammalian Species, Special Formula and Plant-Based Beverages.
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Verduci, Elvira, D'Elios, Sofia, Cerrato, Lucia, Comberiati, Pasquale, Calvani, Mauro, Palazzo, Samuele, Martelli, Alberto, Landi, Massimo, Trikamjee, Thulja, and Peroni, Diego G
- Abstract
Cow's milk and dairy are commonly consumed foods in the human diet and contribute to maintaining a healthy nutritional state, providing unique sources of energy, calcium, protein, and vitamins, especially during early childhood. Milk formula is usually made from cow's milk and represents the first food introduced into an infant's diet when breastfeeding is either not possible or insufficient to cover nutritional needs. Very recently, increased awareness of cow's milk protein allergy and intolerance, and higher preference to vegan dietary habits have influenced parents towards frequently choosing cows' milk substitutes for children, comprising other mammalian milk types and plant-based milk beverages. However, many of these milk alternatives do not necessarily address the nutritional requirements of infants and children. There is a strong need to promote awareness about qualitative and quantitative nutritional compositions of different milk formulas, in order to guide parents and medical providers selecting the best option for children. In this article, we sought to review the different compositions in terms of macronutrients and micronutrients of milk from different mammalian species, including special milk formulas indicated for cow's milk allergy, and of plant-based milk alternatives. [ABSTRACT FROM AUTHOR]
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- 2019
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20. Prevalence and Clinical Relevance of IgE Sensitization to Profilin in Childhood: A Multicenter Study
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Dondi, A, Tripodi, S, Panetta, V, Asero, R, Businco, Ad, Bianchi, A, Carlucci, A, Ricci, G, Bellini, F, Maiello, N, del Giudice, Mm, Frediani, T, Sodano, S, Dello Iacono, I, Macrì, F, Massaccesi, V, Caffarelli, C, Rinaldi, L, Patria, Mf, Varin, E, Peroni, Diego, Chinellato, I, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Tosca, M, Paravati, F, La Grutta, S, Meglio, P, Calvani, M, Plebani, M, Matricardi, Pm, Asero, Riccardo, Tripodi, Salvatore, Dondi, Arianna, Di Rienzo Businco, Andrea, Sfika, Ifigenia, Bianchi, Annamaria, Candelotti, Paolo, Caffarelli, Carlo, Povesi Dascola, Carlotta, Ricci, Giampaolo, Calamelli, Elisabetta, Maiello, Nunzia, MIRAGLIA DEL GIUDICE, Michele, Frediani, Tullio, Frediani, Simone, Macri, Francesco, Moretti, Matteo, Iacono, Iride Dello, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Plebani, Mario, Verga, Carmen, Matricardi, Paolo Maria, and Del Giudice, Michele Miraglia
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Male ,Allergy ,Profilin ,Prevalence ,Immunoglobulin E ,Allergic rhinitis ,Children ,Component-resolved diagnosis ,IgE ,Oral allergy syndrome ,Panallergens ,Pollen ,Allergens ,Antigens, Plant ,Carrier Proteins ,Child ,Cross Reactions ,Cucumis sativus ,Female ,Fruit ,Humans ,Hypersensitivity ,Italy ,Poaceae ,Profilins ,Rhinitis, Allergic, Seasonal ,Risk Factors ,Skin Tests ,Immunology and Allergy ,Immunology ,Medicine (all) ,Epidemiology ,Outpatient clinic ,Sensitization ,Rhinitis ,Skin Test ,biology ,Allergen ,food and beverages ,General Medicine ,medicine.anatomical_structure ,Cross Reaction ,Human ,medicine.medical_specialty ,Allergic rhinitis, Children, Component-resolved diagnosis, IgE , Oral allergy syndrome, Panallergens, Pollen, Profilin ,Socio-culturale ,macromolecular substances ,Component-resolved diagnosi ,Allergic ,Allergic rhiniti ,medicine ,Antigens ,Settore MED/38 - Pediatria Generale e Specialistica ,Seasonal ,business.industry ,Risk Factor ,Plant ,medicine.disease ,Cucumis sativu ,biology.protein ,Panallergen ,Carrier Protein ,business - Abstract
Background: Little is known about the prevalence and clinical relevance of hypersensitivity to the plant panallergen profilin in children. Objectives: The present study aimed to investigate prevalence, risk factors and clinical relevance of profilin sensitization in a large cohort of Italian children of different ages living in different geographic areas. Methods: Children with pollen allergy enrolled by 16 pediatric outpatient clinics sited in three main geographic areas of Italy were studied. SPT were carried out with commercial pollen extracts and a commercial purified date palm pollen profilin. IgE specific for allergenic pollen molecules, Phl p 12 (grass profilin) and Pru p 3 (peach lipid transfer protein) were tested by ImmunoCAP FEIA. Results: IgE to Phl p 12 (≥0.35 kU/l) was observed in 296 of the 1,271 participants (23%), including 17 of the 108 (16%) preschool children. Profilin SPT was positive (≥3 mm) in 320/1,271 (25%) participants. The two diagnostic methods were concordant in 1,151 (91%, p < 0.0001) cases. Phl p 12 IgE prevalence declined from northern to southern Italy and was directly associated with IgE to Phl p 1 and/or Phl p 5 and Ole e 1. Among children with IgE to Phl p 12, OAS was provoked by kiwi, melon, watermelon, banana, apricot and cucumber. Conclusions: Profilin sensitization is very frequent among pollen-allergic children, occurs at a very young age and contributes to the development of childhood OAS with a typical pattern of offending foods. Pediatricians should always consider IgE sensitization to profilin while examining pollen-allergic children, even if they are at preschool age.
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- 2015
21. Utility of Specific IgE to Ara h 2 in Italian Allergic and Tolerant Children Sensitized to Peanut
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Pasquale Comberiati, Colavita, L., Minniti, F., Paiola, G., Capristo, C., Incorvaia, C., Peroni, D. G., Comberiati, Pasquale, Colavita, Laura, Minniti, Federica, Paiola, Giulia, Capristo, Carlo, Incorvaia, Cristoforo, and Peroni, Diego Giampiero
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Allergy ,Ara h 2 ,specific IgE ,food and beverages ,Original Article ,peanut - Abstract
Emerging data suggest that measurement of serum IgE to peanut components can be clinically helpful and more accurate than IgE to whole peanut to predict peanut allergy. Not all studies have used prospective samples, multiple components and oral challenges. Currently, there are no data on this topic involving Italian children. 32 patients (23 males; median age 9 years) with reported history for peanut allergy and evidence of peanut sensitization (skin prick test to peanut extract ≥ 3mm) have been analyzed for serum IgE to whole peanut and recombinant allergen components Ara h 1, 2, 3, 8, and 9 with Immuno CAP and completed an open oral food challenge with peanut. 12 (37.5%) children had a positive challenge to peanut and were considered allergic. No differences were seen between the median values of IgE to peanut, Ara h 1, 3, 8 and 9 in allergic and tolerant children to peanut challenge. Noteworthy, 5 of 20 tolerant children had IgE to peanut> 15 kUA/l which is commonly considered a predictive value of peanut allergy. Conversely, a significant difference was seen when comparing the median value of IgE to Ara h 2 in the two groups: 0.75 kUA/l (IQR: 0.22-4.34 kUA/l) in allergic children versus 0.1 kUA/l (IQR: 0.1-0.12 kUA/l) in tolerant ones (P< 0.001). IgE levels to Ara h 2 are significantly higher in children that react to oral peanut challenge. Our findings in Italian children have been in line with recent reports in various populations of Northern Europe, the US and Australia and add confirmatory evidence that analysis of IgE to Ara h 2 could reduce the need for peanut challenge in suspected allergic patients.
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- 2016
22. Diagnosis and treatment of pediatric food allergy: an update
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Pasquale Comberiati, Cristina Host, Daniela Posa, Diego Peroni, Francesca Cipriani, Alina Schwarz, Comberiati, Pasquale, Cipriani, Francesca, Schwarz, Alina, Posa, Daniela, Host, Cristina, and Peroni, Diego G
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Component-resolved diagnosis ,medicine.medical_specialty ,Allergy ,MEDLINE ,Socio-culturale ,Wheat Hypersensitivity ,Review ,medicine.disease_cause ,Specific oral tolerance induction ,Anaphylaxis ,Avoidance ,Children ,Food allergy ,Quality of life (healthcare) ,Allergen ,Humans ,Medicine ,Disease management (health) ,Child ,Egg Hypersensitivity ,Intensive care medicine ,business.industry ,Anaphylaxis, Avoidance, Children, Component-resolved diagnosis, Food allergy, Specific oral tolerance induction ,medicine.disease ,Immunology ,Nut Hypersensitivity ,Milk Hypersensitivity ,business ,Food Hypersensitivity ,Human - Abstract
The prevalence of pediatric food allergy and anaphylaxis has increased in the last decades, especially in westernized countries where this emerging phenomenon was marked as a “second wave” of the allergic epidemic. Over recent years great advances have been achieved in the field of in vitro allergy testing and component-resolved diagnosis has increasingly entered clinical practice. Testing for allergen components can contribute to a more precise diagnosis by discriminating primary from cross-reactive sensitizations and assessing the risk of severe allergic reactions. The basic concept of the management of food allergy in children is also changing. Avoidance of the offending food is still the mainstay for disease management, especially in primary health care settings, but it severely affects the patients’ quality of life without reducing the risk of accidental allergic reactions. There is a growing body of evidence to show that specific oral tolerance induction can represent a promising treatment option for food allergic patients. In parallel, education of food allergic patients and their caregivers as well as physicians about anaphylaxis and its treatment is becoming recognized a fundamental need. International guidelines have recently integrated these new evidences and their broad application all over Europe represents the new challenge for food allergy specialists.
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- 2015
23. Therapeutic Effects of Vitamin D in Asthma and Allergy
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Carlo Capristo, Diego Peroni, Attilio Boner, Cecilia Benetti, Pasquale Comberiati, Benetti, Cecilia, Comberiati, Pasquale, Capristo, Carlo, Boner, Attilio L., and Peroni, Diego G. .
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Allergy ,vitamin D ,Dermatitis ,vitamin D deficiency ,Atopic ,Dermatitis, Atopic ,Food allergy ,Drug Discovery ,medicine ,Vitamin D and neurology ,Hypersensitivity ,Humans ,Risk factor ,Vitamin D ,Allergy, asthma, atopic dermatitis, food allergy, therapy, vitamin D ,Asthma ,Pharmacology ,Pregnancy ,food allergy ,therapy ,Clinical Trials as Topic ,atopic dermatitis ,business.industry ,General Medicine ,Atopic dermatitis ,medicine.disease ,Dietary Supplements ,Food Hypersensitivity ,Immunology ,business - Abstract
In recent years, low vitamin D status has been proposed as a putative risk factor for allergic diseases. A growing body of literature reports low vitamin D levels in atopic patients and supports an association between vitamin D deficiency and risk of adverse asthma and allergies outcomes. Therefore, it has been speculated that vitamin D supplementation may either prevent or reduce the risk of allergic diseases. Birth cohort studies addressing the role of vitamin D intake during pregnancy have shown conflicting results regarding allergy outcomes in offspring. Currently, only a few studies have tried to supplement vitamin D in asthmatic patients, often as an add-on therapy to standard asthma controller medications, and results are not all consistent. There is emerging data to show that vitamin D can enhance the antiinflammatory effects of glucocorticoids and potentially be used as adjuvant therapy in steroid-resistant asthma. Recent in vivo data suggest that vitamin D supplementation may also reduce the severity of atopic dermatitis. This review examines the existing relevant literature focusing on vitamin D supplementation in the treatment of allergic diseases.
- Published
- 2015
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