1. Manganese‐Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols: A Remarkable Macrocyclic Ligand Effect.
- Author
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Li, Faju, Long, Linhong, He, Yan‐Mei, Li, Zeyu, Chen, Hui, and Fan, Qing‐Hua
- Subjects
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ALLYL alcohol , *HYDROAMINATION , *KETONES , *HYDROGEN bonding , *MANGANESE , *ISOPROPYL alcohol - Abstract
A unique family of chiral peraza N6‐macrocyclic ligands, which are conformationally rigid and have a tunable saddle‐shaped cavity, is described. Utilizing their manganese(I) complexes, the first example of earth‐abundant transition metal‐catalyzed asymmetric formal anti‐Markovnikov hydroamination of allylic alcohols was realized, providing a practical access to synthetically important chiral γ‐amino alcohols in excellent yields and enantioselectivities (up to 99 % yield and 98 % ee). The single‐crystal structure of a MnI complex indicates that the manganese atom coordinates with the chiral dialkylamine moiety in a bidentate fashion. Further DFT calculations revealed that five of the six nitrogen atoms in the ligand were engaged in multiple noncovalent interactions with Mn, an isopropanol molecule, and a β‐amino ketone intermediate via coordination, hydrogen bonding, and/or CH⋅⋅⋅π interactions in the transition state, showing a remarkable role of the macrocyclic framework. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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