1. Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe.
- Author
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Speranza G, Morelli CF, Tubaro A, Altinier G, Durì L, and Manitto P
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Chromones administration & dosage, Chromones therapeutic use, Croton Oil, Disaccharides administration & dosage, Disaccharides therapeutic use, Edema chemically induced, Edema diagnosis, Male, Mice, Mice, Inbred Strains, Plant Extracts administration & dosage, Plant Extracts pharmacology, Plant Extracts therapeutic use, Aloe, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Chromones pharmacology, Disaccharides pharmacology, Phytotherapy
- Abstract
A new diglucoside having a 5-methylchromone moiety was isolated from a commercial sample of Cape aloe, the dried exudate from Aloe ferox Miller, and named aloeresin I. Its structure was established as 1 on the basis of spectral and chemical evidence. Aloeresin I (1) (1 micromol/cm2) reduces in vivo the oedematous response (39 %) induced by Croton oil in the mouse ear with the same potency as aloesin, one of the most abundant Cape aloe constituents, and to a higher extent than aloeresin H (2). Indomethacin (0.3 micromol/cm2), the reference anti-inflammatory compound, provokes 61 % oedema inhibition.
- Published
- 2005
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