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Start Over Author "N I Misuno" Topic alpha-defensins
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1. [Effects of human defensin HNP-1 on the production of tumor necrosis factor-alpha by human blood monocytes in vitro]

Author

N I, Misuno, T S, Kolesnikova, R I, Lerer, T, Gants, and N N, Voĭtenok

Subjects
Defensins, Blood Bactericidal Activity, Staphylococcus aureus, alpha-Defensins, Neutrophils, Tumor Necrosis Factor-alpha, Leukocytes, Mononuclear, Humans, Tetradecanoylphorbol Acetate, Blood Proteins, Cells, Cultured, Stimulation, Chemical
Abstract

The influence of human defensin HNP-1 on the synthesis of tumor necrosis factor-alpha (TNF-alpha) by human blood monocytes was studied. It was shown that TNF-alpha production by human monocytes activated by SAC or PMA was augmented in the presence of HNP-1 concentrations of 10(-8)-10(-9) M. HNP-1 alone induced no synthesis of TNF-alpha. High concentration of HNP-1 (10(-4) M) was cytotoxic for human monocytes.

Published
1992

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