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1. Alpha-1-antitrypsin deficiency resulting in a hitherto unseen presentation of hepatocellular carcinoma: polycythemia but with normal alpha fetoprotein.

Author

Owen DR, Sivakumar R, Suh ES, and Seevaratnam M

Subjects
Aged, Carcinoma, Hepatocellular diagnosis, Carcinoma, Hepatocellular etiology, Humans, Liver Neoplasms diagnosis, Liver Neoplasms etiology, Male, Carcinoma, Hepatocellular metabolism, Liver Neoplasms metabolism, Polycythemia etiology, alpha 1-Antitrypsin metabolism, alpha 1-Antitrypsin Deficiency metabolism, alpha-Fetoproteins metabolism
Abstract

Polycythemia is a known paraneoplastic manifestation of hepatoma, but only in the presence of alpha-fetopro (AFP). We present a case of polycythemia in the absence of AFP, and suggest concurrent alpha-1-antitrypsin deficiency as the cause for breaking this rule. We also suggest a reason for the apparent constant conjunction between polycythemia and AFP in hepatoma.

Published
2006
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