1. Allosteric modulation of nicotinic and GABA
- Author
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Ryan F, Yoshimura, Minhtam B, Tran, Derk J, Hogenkamp, Narielle L, Ayala, Timothy, Johnstone, Andrew J, Dunnigan, Timothy K, Gee, and Kelvin W, Gee
- Subjects
Male ,Behavior, Animal ,alpha7 Nicotinic Acetylcholine Receptor ,Autism Spectrum Disorder ,Mice, Transgenic ,Isoxazoles ,Motor Activity ,Receptors, GABA-A ,Grooming ,Mice, Inbred C57BL ,Disease Models, Animal ,Allosteric Regulation ,Animals ,Humans ,Anilides ,Social Behavior - Abstract
Autism spectrum disorder (ASD) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. There are no FDA-approved drugs for the core symptoms and the changes that underlie these behaviors are not fully understood. One hypothesis is an imbalance of the excitation (E)/inhibition (I) ratio with excessive E and diminished I occurring in specific neuronal circuits. Data suggests that both gamma-aminobutyric acid
- Published
- 2017