1. White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta
- Author
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Freeze, W.M., Jacobs, H.I.L., Gronenschild, E.H., Jansen, J.F.A., Burgmans, S., Aalten, P., Clerx, L., Vos, S.J., Buchem, M.A. van, Barkhof, F., Flier, W.M. van der, Verbeek, M.M., Rikkert, M.O., Backes, W.H., Verhey, F.R., LeARN Project, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Neurology, Epidemiology and Data Science, Promovendi MHN, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Beeldvorming, MUMC+: DA BV Klinisch Fysicus (9), and MUMC+: MA Med Staf Spec Psychiatrie (9)
- Subjects
0301 basic medicine ,Male ,Pathology ,MILD COGNITIVE IMPAIRMENT ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,CEREBROVASCULAR-DISEASE ,Neuropsychological Tests ,Hippocampus ,0302 clinical medicine ,Cognition ,Hippocampus (mythology) ,education.field_of_study ,CEREBRAL MICROBLEEDS ,biology ,medicine.diagnostic_test ,cerebral small vessel disease ,General Neuroscience ,SUBCORTICAL VASCULAR DEMENTIA ,neurodegeneration ,General Medicine ,Organ Size ,CEREBROSPINAL-FLUID BIOMARKERS ,Middle Aged ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Magnetic Resonance Imaging ,White Matter ,ALZHEIMERS-DISEASE ,Psychiatry and Mental health ,Clinical Psychology ,medicine.anatomical_structure ,Female ,Alzheimer's disease ,Amyloid-beta ,Psychology ,medicine.medical_specialty ,Amyloid beta ,NORMATIVE DATA ,Population ,SMALL-VESSEL DISEASE ,White matter ,03 medical and health sciences ,Alzheimer Disease ,mental disorders ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,education ,A-BETA ,Aged ,Cerebral Hemorrhage ,Amyloid beta-Peptides ,Magnetic resonance imaging ,medicine.disease ,Hyperintensity ,nervous system diseases ,030104 developmental biology ,Cross-Sectional Studies ,Cerebral Small Vessel Diseases ,biology.protein ,Linear Models ,Perception ,Geriatrics and Gerontology ,CORTICAL THICKNESS ,030217 neurology & neurosurgery ,Biomarkers ,dementia - Abstract
Contains fulltext : 170424.pdf (Publisher’s version ) (Closed access) Cerebral small vessel disease (cSVD) and amyloid-beta (Abeta) deposition often co-exist in (prodromal) dementia, and both types of pathology have been associated with neurodegeneration. We examined whether cSVD and Abeta have independent or interactive effects on hippocampal volume (HV) in a memory clinic population. We included 87 individuals with clinical diagnoses of Alzheimer's disease (AD) (n = 24), mild cognitive impairment (MCI) (n = 26), and subjective cognitive complaints (SCC) (n = 37). cSVD magnetic resonance imaging markers included white matter hyperintensity (WMH) volume, lacunar infarct presence, and microbleed presence. Abeta pathology was assessed as cerebrospinal fluid-derived Abeta1 - 42 levels and dichotomized into normal or abnormal, and HV was determined by manual volumetric measurements. A linear hierarchical regression approach was applied for the detection of additive or interaction effects between cSVD and Abeta on HV in the total participant group (n = 87) and in the non-demented group (including SCC and MCI individuals only, n = 63). The results revealed that abnormal Abeta and lacunar infarct presence were independently associated with lower HV in the non-demented individuals. Interestingly, Abeta and WMH pathology interacted in the non-demented individuals, such that WMH had a negative effect on HV in individuals with abnormal CSF Abeta42 levels, but not in individuals with normal CSF Abeta42 levels. These associations were not present when individuals with AD were included in the analyses. Our observations suggest that relatively early on in the disease process older individuals with abnormal Abeta levels are at an increased risk of accelerated disease progression when concomitant cSVD is present.
- Published
- 2016
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