1. An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment.
- Author
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Xia, Shijin, Zhang, Xinyan, Zheng, Songbai, Khanabdali, Ramin, Kalionis, Bill, Wu, Junzhen, Wan, Wenbin, and Tai, Xiantao
- Subjects
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ALZHEIMER'S disease prevention , *ALZHEIMER'S disease treatment , *IMMUNOSENESCENCE , *ATHEROSCLEROSIS , *HEART diseases , *DISEASE progression , *INFLAMMATION treatment , *INFLAMMATION prevention , *AGING , *CELLULAR signal transduction , *CYTOKINES , *DISEASE susceptibility , *INFLAMMATION , *OXIDATION-reduction reaction , *PHYSIOLOGICAL stress - Abstract
Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer's disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by which inflamm-aging affects pathological changes and disease development are still unclear. Here, we review studies of inflamm-aging that explore the concept, pathological features, mechanisms, intervention, and the therapeutic strategies of inflamm-aging in disease progression. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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