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1. Lithium-induced accentuation of extrapyramidal symptoms in individuals with Alzheimer's disease.

Author

Kelwala S, Pomara N, Stanley M, Sitaram N, and Gershon S

Subjects
Acute Disease, Aged, Alzheimer Disease blood, Alzheimer Disease complications, Basal Ganglia Diseases blood, Basal Ganglia Diseases complications, Erythrocytes analysis, Female, Humans, Lithium blood, Lithium Carbonate, Male, Middle Aged, Alzheimer Disease drug therapy, Basal Ganglia Diseases chemically induced, Lithium adverse effects
Abstract

Lithium treatment in 9 elderly individuals with Alzheimer's disease led to a marked accentuation of extra-pyramidal symptoms (EPS) in 5 of 6 patients with preexisting EPS. EPS scores significantly correlated with plasma and RBC lithium levels. Lithium treatment had no such effects in the 3 patients without preexisting extrapyramidal symptoms.

Published
1984

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