Search

Your search keyword '"Stirpe, Paola"' showing total 10 results
Start Over Author "Stirpe, Paola" Topic alzheimer disease
10 results on '"Stirpe, Paola"'

1. Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases.

Author

Babiloni C, Del Percio C, Pascarelli MT, Lizio R, Noce G, Lopez S, Rizzo M, Ferri R, Soricelli A, Nobili F, Arnaldi D, Famà F, Orzi F, Buttinelli C, Giubilei F, Salvetti M, Cipollini V, Franciotti R, Onofrj M, Stirpe P, Fuhr P, Gschwandtner U, Ransmayr G, Aarsland D, Parnetti L, Farotti L, Marizzoni M, D'Antonio F, De Lena C, Güntekin B, Hanoğlu L, Yener G, Emek-Savaş DD, Triggiani AI, Taylor JP, McKeith I, Stocchi F, Vacca L, Hampel H, Frisoni GB, De Pandis MF, and Bonanni L

Subjects
Aged, Female, Humans, Male, Alpha Rhythm, Alzheimer Disease complications, Cerebral Cortex physiopathology, Cognitive Dysfunction etiology, Cognitive Dysfunction physiopathology, Lewy Body Disease complications, Rest physiology
Abstract

Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2019
Full Text
View/download PDF

2. Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study.

Author

Babiloni C, Del Percio C, Lizio R, Noce G, Lopez S, Soricelli A, Ferri R, Nobili F, Arnaldi D, Famà F, Aarsland D, Orzi F, Buttinelli C, Giubilei F, Onofrj M, Stocchi F, Stirpe P, Fuhr P, Gschwandtner U, Ransmayr G, Garn H, Fraioli L, Pievani M, Frisoni GB, D'Antonio F, De Lena C, Güntekin B, Hanoğlu L, Başar E, Yener G, Emek-Savaş DD, Triggiani AI, Franciotti R, Taylor JP, Vacca L, De Pandis MF, and Bonanni L

Subjects
Aged, Cerebral Cortex diagnostic imaging, Cortical Synchronization physiology, Dementia diagnosis, Dementia physiopathology, Female, Humans, Male, Alzheimer Disease complications, Cerebral Cortex physiology, Cognition physiology, Dementia etiology, Dementia psychology, Electroencephalography, Lewy Body Disease complications, Rest physiology
Abstract

Previous evidence showed abnormal posterior sources of resting-state delta (<4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Nold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values >0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2018
Full Text
View/download PDF

3. Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases.

Author

Babiloni C, Del Percio C, Lizio R, Noce G, Lopez S, Soricelli A, Ferri R, Pascarelli MT, Catania V, Nobili F, Arnaldi D, Famà F, Orzi F, Buttinelli C, Giubilei F, Bonanni L, Franciotti R, Onofrj M, Stirpe P, Fuhr P, Gschwandtner U, Ransmayr G, Garn H, Fraioli L, Pievani M, D'Antonio F, De Lena C, Güntekin B, Hanoğlu L, Başar E, Yener G, Emek-Savaş DD, Triggiani AI, Taylor JP, De Pandis MF, Vacca L, Frisoni GB, and Stocchi F

Subjects
Aged, Alzheimer Disease diagnosis, Alzheimer Disease psychology, Cognitive Dysfunction diagnosis, Cognitive Dysfunction psychology, Female, Humans, Male, Neuropsychological Tests, Parkinson Disease diagnosis, Parkinson Disease psychology, Rest physiology, Retrospective Studies, Alpha Rhythm physiology, Alzheimer Disease physiopathology, Cerebral Cortex physiology, Cognitive Dysfunction physiopathology, Electroencephalography methods, Parkinson Disease physiopathology
Abstract

Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold)., Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals., Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70-0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups., Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels., Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment., (Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)

Published
2018
Full Text
View/download PDF

4. Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases.

Author

Babiloni C, Del Percio C, Lizio R, Noce G, Lopez S, Soricelli A, Ferri R, Pascarelli MT, Catania V, Nobili F, Arnaldi D, Famà F, Aarsland D, Orzi F, Buttinelli C, Giubilei F, Onofrj M, Stocchi F, Vacca L, Stirpe P, Fuhr P, Gschwandtner U, Ransmayr G, Garn H, Fraioli L, Pievani M, Frisoni GB, D'Antonio F, De Lena C, Güntekin B, Hanoğlu L, Başar E, Yener G, Emek-Savaş DD, Triggiani AI, Franciotti R, Taylor JP, De Pandis MF, and Bonanni L

Subjects
Aged, Alzheimer Disease complications, Alzheimer Disease diagnosis, Alzheimer Disease drug therapy, Brain drug effects, Cognitive Dysfunction diagnosis, Cognitive Dysfunction drug therapy, Cognitive Dysfunction etiology, Educational Status, Female, Humans, Lewy Body Disease complications, Lewy Body Disease diagnosis, Lewy Body Disease drug therapy, Male, Psychotropic Drugs therapeutic use, Rest, Retrospective Studies, Signal Processing, Computer-Assisted, Alzheimer Disease physiopathology, Brain physiopathology, Cognitive Dysfunction physiopathology, Electroencephalography, Lewy Body Disease physiopathology
Abstract

The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC >0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers.

Published
2018
Full Text
View/download PDF

5. Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study.

Author

Babiloni C, Del Percio C, Lizio R, Noce G, Cordone S, Lopez S, Soricelli A, Ferri R, Pascarelli MT, Nobili F, Arnaldi D, Aarsland D, Orzi F, Buttinelli C, Giubilei F, Onofrj M, Stocchi F, Stirpe P, Fuhr P, Gschwandtner U, Ransmayr G, Caravias G, Garn H, Sorpresi F, Pievani M, Frisoni GB, D'Antonio F, De Lena C, Güntekin B, Hanoğlu L, Başar E, Yener G, Emek-Savaş DD, Triggiani AI, Franciotti R, De Pandis MF, and Bonanni L

Subjects
Aged, Female, Humans, Male, Ocular Physiological Phenomena, Rest physiology, Retrospective Studies, Alzheimer Disease physiopathology, Cerebral Cortex physiopathology, Cortical Synchronization physiology, Electroencephalography, Lewy Body Disease physiopathology
Abstract

The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini-Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85-0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
Full Text
View/download PDF

6. Abnormalities of Cortical Neural Synchronization Mechanisms in Subjects with Mild Cognitive Impairment due to Alzheimer's and Parkinson's Diseases: An EEG Study.

Author

Babiloni C, Del Percio C, Lizio R, Noce G, Cordone S, Lopez S, Soricelli A, Ferri R, Pascarelli MT, Nobili F, Arnaldi D, Famà F, Aarsland D, Orzi F, Buttinelli C, Giubilei F, Onofrj M, Stocchi F, Stirpe P, Fuhr P, Gschwandtner U, Ransmayr G, Caravias G, Garn H, Sorpresi F, Pievani M, D'Antonio F, De Lena C, Güntekin B, Hanoğlu L, Başar E, Yener G, Emek-Savaş DD, Triggiani AI, Franciotti R, Frisoni GB, Bonanni L, and De Pandis MF

Subjects
Aged, Aged, 80 and over, Electroencephalography, Female, Humans, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Retrospective Studies, Spectrum Analysis, Alzheimer Disease complications, Brain Waves physiology, Cerebral Cortex physiopathology, Cognitive Dysfunction etiology, Cognitive Dysfunction pathology, Parkinson Disease complications
Abstract

The aim of this retrospective and exploratory study was that the cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and Parkinson's disease (PDMCI) as compared to healthy subjects. Clinical and rsEEG data of 75 ADMCI, 75 PDMCI, and 75 cognitively normal elderly (Nold) subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) was matched between the ADMCI and PDMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROC) classified these sources across individuals. Results showed that compared to the Nold group, the posterior alpha2 and alpha3 source activities were more abnormal in the ADMCI than the PDMCI group, while the parietal delta source activities were more abnormal in the PDMCI than the ADMCI group. The parietal delta and alpha sources correlated with MMSE score and correctly classified the Nold and diseased individuals (area under the ROC = 0.77-0.79). In conclusion, the PDMCI and ADMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test these rsEEG markers for clinical applications and drug discovery.

Published
2017
Full Text
View/download PDF

7. Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Author

Maria Francesca De Pandis, Laura Bonanni, Moira Marizzoni, Maria Teresa Pascarelli, Susanna Lopez, Roberta Lizio, Giuseppe Noce, Fabrizio Stocchi, Raffaele Ferri, Marco Rizzo, Lucia Farotti, Carlo de Lena, Görsev Yener, Lutfu Hanoglu, Flavio Nobili, Claudio Babiloni, Bahar Güntekin, Gerhard Ransmayr, Raffaella Franciotti, H. Hampel, Francesco Orzi, Andrea Soricelli, Marco Salvetti, Peter Fuhr, Franco Giubilei, Fabrizia D'Antonio, Giovanni B. Frisoni, Ian G. McKeith, Derya Durusu Emek-Savaş, Dario Arnaldi, Paola Stirpe, Carla Buttinelli, Marco Onofrj, Francesco Famà, Lucilla Parnetti, Virginia Cipollini, Dag Aarsland, John-Paul Taylor, Claudio Del Percio, Antonio Ivano Triggiani, Laura Vacca, Ute Gschwandtner, Frisoni, Giovanni, Babiloni, Claudio, Del Percio, Claudio, Pascarelli, Maria Teresa, Lopez, Susanna Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Ple A Moro 5, I-00185 Rome, Italy, De Pandis, Maria Francesca Hosp San Raffaele Cassino, Cassino, FR, Italy, Rizzo, Marco, Ferri, Raffaele Oasi Res Inst IRCCS, Troina, Italy, Lizio, Roberta, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Nobili, Flavio, Arnaldi, Dario IRCCS Osped Policlin San Martino, Clin Neurol, Genoa, Italy, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dipartimento Neurosci Oftalmol Genet Riabilitaz &, Genoa, Italy, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Salvetti, Marco, Cipollini, Virginia Sapienza Univ Rome, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Salvetti, Marco IRCCS Ist Neurol Mediterraneo INM Neuromed Pozzil, Neuromed, Isernia, Italy, Franciotti, Raffaella, Onofrjt, Marco, Bonanni, Laura Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Bonanni, Laura Univ G dAnnunzio, CESI, Chieti, Italy, Stirpe, Paola, Stocchi, Fabrizio, Vacca, Laura IRCCS San Raffaele Pisana, Rome, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Neurol 2, Med Campus 3, Linz, Austria, Aarsland, Dag Kings Coll Univ, Dept Old Age Psychiat, London, England, Parnetti, Lucilla, Farotti, Lucia Univ Perugia, Ctr Memory Disturbances, Sect Neurol, Lab Clin Neurochem, Perugia, Italy, Marizzoni, Moira, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Human Neurosci, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Int Sch Med, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Istanbul Medipol Univ, Sch Med, Dept Neurol, Istanbul, Turkey, Yener, Gorsev Dokuz Eylul Univ, Dept Neurosci, Med Sch, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, Dept Neurol, Med Sch, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul, McKeith, Ian Newcastle Univ, Inst Neurosci, Newcastle, NSW, Australia, Hampel, Harald Brain & Spine Inst ICM, Inst Memory & Alzheimers Dis IM2A, Dept Neurol, Paris, France, Frisoni, Giovanni B. Univ Hosp, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, nobili, flavio -- 0000-0001-9811-0897, Ferri, Raffaele -- 0000-0001-6937-3065, Aarsland, Dag -- 0000-0001-6314-216X, triggiani, antonio ivano -- 0000-0003-3291-9452, and Babiloni, Claudio -- 0000-0002-5245-9839

Subjects
0301 basic medicine, Lewy Body Disease, Male, medicine.medical_specialty, Aging, Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to dementia with Lewy body (DLBMCI), Resting state EEG rhythms, Aged, Alzheimer Disease, Cerebral Cortex, Cognitive Dysfunction, Female, Humans, Rest, Alpha Rhythm, Alpha (ethology), Alzheimer's Disease (ADMCI), Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to dementia with Lewy body (DLBMCI), Resting state EEG rhythms, Neuroscience (all), Aging, Neurology (clinical), Developmental Biology, Geriatrics and Gerontology, Audiology, 03 medical and health sciences, 0302 clinical medicine, mental disorders, Mild Cognitive Impairment Due To, Medicine, Dementia, Mini–Mental State Examination, Neuroscience (all), Lewy body, Resting state fMRI, medicine.diagnostic_test, Receiver operating characteristic, business.industry, General Neuroscience, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Cerebral cortex, ddc:618.97, Neurology (clinical), Alzheimer's disease, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, functional brain connectivity, mild cognitive impairment due to Alzheimer's disease (ADMCI), mild cognitive impairment due to dementia with Lewy body (DLBMCI), resting state EEG rhythms, neuroscience (all), aging, neurology (clinical), developmental biology, geriatrics and gerontology, Developmental Biology
Abstract

WOS: 000465302200012 PubMed ID: 30797169 Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (

Published
2019

8. Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases

Author

Susanna Lopez, Lutfu Hanoglu, Raffaele Ferri, Raffaella Franciotti, Lucia Fraioli, Heinrich Garn, Francesco Famà, Dag Aarsland, Fabrizia D'Antonio, Bahar Güntekin, Andrea Soricelli, Peter Fuhr, Maria Francesca De Pandis, Görsev Yener, Marco Onofrj, Maria Teresa Pascarelli, Laura Bonanni, Carla Buttinelli, Francesco Orzi, Valentina Catania, Claudio Babiloni, Franco Giubilei, Erol Başar, Giuseppe Noce, Gerhard Ransmayr, John-Paul Taylor, Michela Pievani, Giovanni B. Frisoni, Claudio Del Percio, Antonio Ivano Triggiani, Carlo de Lena, Flavio Nobili, Laura Vacca, Derya Durusu Emek-Savaş, Ute Gschwandtner, Roberta Lizio, Dario Arnaldi, Paola Stirpe, Fabrizio Stocchi, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy, Stocchi, Fabrizio, Vacca, Laura, Stirpe, Paola IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neuroscience DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS AOU S Martino IST, Genoa, Italy, Aarsland, Dag Kings Coll Univ, Dept Old Age Psychiat, London, England, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Onofrj, Marco, Franciotti, Raffaella, Bonanni, Laura Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Bonanni, Laura Univ G dAnnunzio, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Med Fac, Kepler Univ Hosp, Dept Neurol 2, Med Campus 3, Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia Hosp San Raffaele Cassino, Cassino, Italy, Pievani, Michela, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, Frisoni, Giovanni B. Univ Hosp Geneva, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp Geneva, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Basar, Erol, Yener, Gorsev Dokuz Eylul Univ, IBG, Dept Neurol, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, IBG, Dept Neurosci, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, England, Guntekin, Bahar -- 0000-0002-0860-0524, Ferri, Raffaele -- 0000-0001-6937-3065, Pievani, Michela -- 0000-0002-1794-8987, triggiani, antonio ivano -- 0000-0003-3291-9452, Taylor, John-Paul -- 0000-0001-7958-6558, and Aarsland, Dag -- 0000-0001-6314-216X

Subjects
0301 basic medicine, Male, Audiology, 0302 clinical medicine, mild cognitive impairment due to dementia with Lewy bodies, media_common, resting state electroencephalographic rhythms, medicine.diagnostic_test, Exact low resolution brain electromagnetic source tomography (eLORETA), General Neuroscience, Brain, Electroencephalography, Signal Processing, Computer-Assisted, General Medicine, Psychiatry and Mental health, Clinical Psychology, mild cognitive impairment due to Alzheimer’s disease, receiver operating characteristic curve, Educational Status, Female, Alzheimer's disease, Vigilance (psychology), Lewy Body Disease, medicine.medical_specialty, media_common.quotation_subject, Rest, 03 medical and health sciences, Exact low resolution brain electromagnetic source tomography (eLORETA), mild cognitive impairment due to Alzheimer's disease, mild cognitive impairment due to dementia with Lewy bodies, receiver operating characteristic curve, resting state electroencephalographic rhythms, Alzheimer Disease, medicine, Humans, Cognitive Dysfunction, Aged, Retrospective Studies, Psychotropic Drugs, Mini–Mental State Examination, Resting state fMRI, Lewy body, Dementia with Lewy bodies, business.industry, medicine.disease, Mild Cognitive Impairment Due to Alzheimer's Disease, 030104 developmental biology, Delta Rhythm, ddc:618.97, Geriatrics and Gerontology, Occipital lobe, business, 030217 neurology & neurosurgery
Abstract

WOS: 000424245200019 PubMed ID: 29439335 The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC > 0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers. H2020 Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Bodies. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-itn-etn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.

Published
2018

9. Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

Author

Franco Giubilei, Ute Gschwandtner, Raffaella Franciotti, Roberta Lizio, Gerhard Ransmayr, Fabrizio Stocchi, Dag Aarsland, John-Paul Taylor, Giuseppe Noce, Bahar Güntekin, Laura Vacca, Claudio Babiloni, Raffaele Ferri, Peter Fuhr, Antonio Ivano Triggiani, Dario Arnaldi, Lucia Fraioli, Claudio Del Percio, Paola Stirpe, Susanna Lopez, Lutfu Hanoglu, Francesco Orzi, Marco Onofrj, Laura Bonanni, Maria Francesca De Pandis, Carlo de Lena, Flavio Nobili, Andrea Soricelli, Michela Pievani, Giovanni B. Frisoni, Derya Durusu Emek-Savaş, Carla Buttinelli, Francesco Famà, Erol Başar, Heinrich Garn, Görsev Yener, Fabrizia D'Antonio, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy, Stocchi, Fabrizio, Stirpe, Paola, Vacca, Laura IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS, SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele IRCCS, Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neurosci DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS, AOU S Martino IST, Genoa, Italy, Aarsland, Dag Kings Coll Univ, Dept Old Age Psychiat, London, England, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Onofrj, Marco, Franciotti, Raffaella, Bonanni, Laura Univ G Annunzio Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Bonanni, Laura Univ G Annunzio Chieti Pescara, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spita Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Gen Hosp City Linz, Dept Neurol & Psychiat, Linz, Austria, Ransmayr, Gerhard Johannes Kepler Univ Linz, Gen Hosp City Linz, Fac Med, Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia, De Pandis, Maria Francesca Hosp San Raffaele Cassino, Cassino, Italy, Pievani, Michela, Frisoni, Giovanni B. IRCCS, Ist Ctr San Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, Frisoni, Giovanni B. Univ Hosp, Lab Neuroimaging Aging, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp, Lab Neuroimaging Aging, LANVIE, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Bazar, Erol, Yener, Gorsev Dokuz Eyliil Univ, IBG, Dept Neurol, Izmir, Turkey, Yener, Gorsev Dokuz Eyliil Univ, IBG, Dept Neurosci, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eyliil Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eyliil Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, NSW, Australia, Vacca, Laura Casa Cura Privata Policlin CCPP Milano SpA, Milan, Italy, Guntekin, Bahar -- 0000-0002-0860-0524, Pievani, Michela -- 0000-0002-1794-8987, triggiani, antonio ivano -- 0000-0003-3291-9452, Ferri, Raffaele -- 0000-0001-6937-3065, Stocchi, Fabrizio -- 0000-0002-5763-0033, Babiloni, Claudio -- 0000-0002-5245-9839, Emek-Savas, Derya Durusu -- 0000-0001-7042-697X, Taylor, John-Paul -- 0000-0001-7958-6558, nobili, flavio -- 0000-0001-9811-0897, and Aarsland, Dag -- 0000-0001-6314-216X

Subjects
0301 basic medicine, Male, Aging, Parkinson's disease, Resting-state EEG rhythms, Dementia with Lewy bodies, Audiology, Electroencephalography, neuroscience, 0302 clinical medicine, Cognition, Resting State EEG Rhythms, Cortical Synchronization, Cognition/physiology, Cerebral Cortex, medicine.diagnostic_test, General Neuroscience, Neurodegenerative diseases, Alzheimer's disease, 16. Peace & justice, Dementia/diagnosis/etiology/physiopathology/psychology, Cortical Synchronization/physiology, Female, Alzheimer’s disease, Lewy Body Disease, medicine.medical_specialty, animal structures, Alzheimer Disease/complications, Rest, Alpha (ethology), behavioral disciplines and activities, 03 medical and health sciences, Lewy Body Disease/complications, Alzheimer Disease, mental disorders, medicine, Dementia, Humans, Dementia with Lewy Bodies, Functional brain connectivity, Neuroscience (all), Neurology (clinical), Developmental Biology, Geriatrics and Gerontology, Resting state EEG rhythms, dementia, dementia with Lewy bodies, functional brain connectivity, neurodegenerative diseases, resting-state EEG rhythms, aging, neurology (clinical), developmental biology, geriatrics and gerontology, Aged, Mini–Mental State Examination, Lewy body, Resting state fMRI, Rest/physiology, medicine.disease, nervous system diseases, 030104 developmental biology, ddc:618.97, Parkinson’s disease, Cerebral Cortex/diagnostic imaging/physiology, 030217 neurology & neurosurgery
Abstract

WOS: 000428233700003 PubMed ID: 29407464 Previous evidence showed abnormal posterior sources of resting-state delta (< 4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Hold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values > 0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels. (C) 2017 Elsevier Inc. All rights reserved. H2020 Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the consortia are reported in the cover page of this manuscript. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bddiag-itn-etn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.

Published
2018
Full Text
View/download PDF

10. Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases

Author

Raffaele Ferri, Susanna Lopez, Lutfu Hanoglu, Lucia Fraioli, Ute Gschwandtner, Francesco Orzi, Görsev Yener, Marco Onofrj, Gerhard Ransmayr, Laura Vacca, John-Paul Taylor, Raffaella Franciotti, Laura Bonanni, Bahar Güntekin, Andrea Soricelli, Michela Pievani, Giovanni B. Frisoni, Francesco Famà, Fabrizia D'Antonio, Peter Fuhr, Roberta Lizio, Giuseppe Noce, Maria Francesca De Pandis, Dario Arnaldi, Valentina Catania, Carlo de Lena, Antonio Ivano Triggiani, Flavio Nobili, Claudio Babiloni, Claudio Del Percio, Paola Stirpe, Erol Başar, Fabrizio Stocchi, Maria Teresa Pascarelli, Heinrich Garn, Derya Durusu Emek-Savaş, Franco Giubilei, Carla Buttinelli, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Ple A Moro 5, I-00185 Rome, Italy, Stirpe, Paola, Stocchi, Fabrizio IRCCS San Raffaele Pisana Roma & Cassino, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neurosci DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS AOU S Martino IST, Genoa, Italy, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Bonanni, Laura, Franciotti, Raffaella, Onofrj, Marco Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Onofrj, Marco Univ G dAnnunzio, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Petersgraben 4, CH-4031 Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Neurol 2, Med Campus 3,Krankenhausstr 9, A-4020 Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia, De Pandis, Maria Francesca Hosp San Raffaele Cassino, Cassino, Italy, Pievanim, Michela, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, D'Antonio, Fabrizia, De Lena, Carlo Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Basar, Erol, Yener, Gorsev, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, Med Sch, Dept Neurol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, England, Vacca, Laura CCPP Milano SpA, Milan, Italy, Frisoni, Giovanni B. Univ Hosp Geneva, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp Geneva, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, Pievani, Michela -- 0000-0002-1794-8987, Ferri, Raffaele -- 0000-0001-6937-3065, Guntekin, Bahar -- 0000-0002-0860-0524, triggiani, antonio ivano -- 0000-0003-3291-9452, Taylor, John-Paul -- 0000-0001-7958-6558, nobili, flavio -- 0000-0001-9811-0897, Emek-Savas, Derya Durusu -- 0000-0001-7042-697X, and Stocchi, Fabrizio -- 0000-0002-5763-0033

Subjects
0301 basic medicine, Male, functional brain connectivity, mild cognitive impairment due to Alzheimer's disease (ADMCI), mild cognitive impairment due to Parkinson's disease (PDMCI), resting state EEG rhythms, sensory systems, neurology, physiology, Audiology, Neuropsychological Tests, 0302 clinical medicine, Mild Cognitive Impairment Due To, Beta Rhythm, Functional Brain Connectivity, Resting State EEG Rhythms, Cognitive impairment, Cerebral Cortex, Electroencephalography, Parkinson Disease, Sensory Systems, 3. Good health, Alpha Rhythm, Neurology, Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to Parkinson's disease (PDMCI), Resting state EEG rhythms, Sensory Systems, Neurology, Neurology (clinical), Physiology (medical), Female, Alzheimer's disease, Abnormality, medicine.medical_specialty, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Rest, Alpha (ethology), Alzheimer's Disease (ADMCI), Mild cognitive impairment due to Parkinson's disease (PDMCI), 03 medical and health sciences, Alpha rhythm, Alzheimer Disease, Physiology (medical), medicine, Humans, Cognitive Dysfunction, Resting state EEG rhythms, Aged, Retrospective Studies, Resting state fMRI, Receiver operating characteristic, business.industry, Functional brain connectivity, Parkinson's Disease (PDMCI), medicine.disease, Neurology (clinical), 030104 developmental biology, ddc:618.97, business, 030217 neurology & neurosurgery
Abstract

WOS: 000427485900009 PubMed ID: 29448151 Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70-0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. H Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. Dr. Erol Basar passed away due to health problems on October 28th (November 18th 1938-October 28th 2017) in Istanbul, during the editorial processing of this manuscript. Until the end of his life, he had been working to the development of EEG science and its application in Clinical Neurophysiology. He leaves to all us an invaluable scientific legacy in the Science of Brain Rhythms and Human Cognition. He also leaves a permanent reminder of scientific passion, academic soul, and social responsibility to all fortunate people who met and knew him during his intense life. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-ITNetn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results