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Total vascular impedance (TVI) characterizes the impediment presented by the arterial tree to the setting-up of the blood flow and pressure. Information provided by TVI could be of fundamental interest to haemodynamic studies or even as an instrument for clinical diagnosis. AIMS: 1-To evaluate the association of clinical and metabolic parameters with TVI. 2-To compare TVI between hyperglycaemic and normoglycaemic groups. METHODS: N=101, 22-89 years. 54/47 M/F ratio. 52, 5% DM2, 71,3% hypertensives, 25% smokers. BMI (kg/m2) and W(cm). Creat, gly, TG, LDL, HDL, total-Chol by HITACHI. Hyperglycaemia according to: American Diabetes Association. Glomerular Filtration Rate(GFR):Cokroft-Gault Equation. Endothelium and non-endothelium dependent (EDV;NEDV): Celermajer Extracellular matrix activity: COMP(U/L): ELISA.hs-CRP(mg/I):ELISA. Ambulatory Blood Pressure Monitoring: Spacelabs 90207.24-hour average systolic, diastolic and mean blood pressure (aSBP, aDBP, aMBP).HbA1c(%):HPLC. Total vascular impedance (dyne.sec.cm5): HDI/ PulseWave CR-2000. Statistical analysis: Mann-Whitney, Chi-squared and Student's T tests. Pearson's coefficient correlation. Multivariate linear regression. RESULTS: 1. TVI presented high correlation with age(p<0,001), with a linear regression slope of β=3,255(p<0,001). 2. Based on experimental data, the cut-off point for increased TVI was set at the 75 percentile. Comparing both groups, normal(TVI<230; n=76) vs increased(TVI≥230; n=25), statistically significant differences were found in age(p<0,001), percentage of fat mass(p=0,001), GFR(p=0,048), NEDV(p=0,012), aDBP(p=0,001), COMP (p=0,042) and hs-CRP (p=0,020). Multivariate linear regression analysis showed that NEDV(p=0,047), and aDBP(p=0,010) were directly related to TVI, adjusting by age and percentage of fat mass. 3. Comparing prediabetic-diabetic patients (n=40) vs non-diabetic patients (n=40), with similar age no significant differences were found in TVI. CONCLUSIONS: 1. Age is the most important factor implicated in TVI, measured by a cardiovascular profiling system. 2. aDBP and NEDV, but not GFR, COMP nor CRP, are directly related to TVI. 3. Unlike NEDV, EDV is not influenced by TVI. 4. Diabetic status, at similar age, does not influence TVI. ADA-Funded Research [ABSTRACT FROM AUTHOR]