1. para-Selective C-H Amidation of Simple Arenes with Nitriles.
- Author
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Xiang, Shi ‐ Kai, Li, Jin ‐ Mei, Huang, He, Feng, Chun, Ni, Hai ‐ Liang, Chen, Xiao ‐ Zhen, Wang, Bi ‐ Qin, Zhao, Ke ‐ Qing, Hu, Ping, and Redshaw, Carl
- Subjects
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AROMATIC compounds , *CATALYSIS , *CHEMICAL industry , *CHEMICAL reactions , *ORGANIC chemistry - Abstract
A para-selective C¢H amidation of simple arenes with nitriles has been developed. By increasing the amount of arenes, a further meta-selective C¢H arylation of the produced amides occurred. Both steric and electronic effects are utilized to control the selectivity, resulting in only para-selective amidation products. The readily available nitriles as amidation reagents instead of amides makes the synthesis of N-arylamides more accessible. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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