Search

Your search keyword '"Josa-Culleré, Laia"' showing total 1 results
Start Over Author "Josa-Culleré, Laia" Topic amide derivatives

Refine your results

1 results on '"Josa-Culleré, Laia"'

1. Chemoselective Formation and Reaction of Densely Functionalised Bicyclic Tetramic Acids and Their Biological Activity.

Author

Josa‐Culleré, Laia, Towers, Christopher, Thompson, Amber L., and Moloney, Mark G.

Subjects
*CHEMOSELECTIVITY, *TETRAMIC acids, *AMIDE derivatives, *RING formation (Chemistry), *CALCIUM
Abstract

Weinreb amide derivatives of tetramates may be effectively accessed by chemoselective Dieckmann reaction, and further react with Grignards in a fully chemoselective reaction, giving rise to unsaturated acyl derivatives not easily available by other routes. These systems are strong chelators of calcium, and some show potent activity against Gram positive bacteria, and one is a first-in-class proteasome inhibitor. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results