1. Biaryl amide glucagon receptor antagonists.
- Author
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Kurukulasuriya R, Sorensen BK, Link JT, Patel JR, Jae HS, Winn MX, Rohde JR, Grihalde ND, Lin CW, Ogiela CA, Adler AL, and Collins CA
- Subjects
- Amides chemistry, Animals, Haplorhini, Humans, Mice, Rats, Rats, Sprague-Dawley, Amides pharmacology, Receptors, Glucagon antagonists & inhibitors
- Abstract
Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.
- Published
- 2004
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