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1. New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.

Author

Cirauqui N, Ceras J, Galiano S, Pérez-Silanes S, Juanenea L, Rivera G, Aldana I, and Monge A

Subjects
Animals, CHO Cells, Cricetinae, Cricetulus, Humans, Indicators and Reagents, Solvents, Structure-Activity Relationship, Amides chemical synthesis, Amides pharmacology, Anti-Obesity Agents chemical synthesis, Anti-Obesity Agents pharmacology, Receptors, Somatostatin antagonists & inhibitors
Abstract

Melanin-concentrating hormone (MCH) is a recently discovered central nervous system (CNS) target for treating obesity. Two novel series of amide derivatives were synthesized and evaluated biologically as MCH-R1 (melanin-concentrating hormone receptor 1) antagonists. The results showed that diphenyl substituents on the amide lead to better activity than biphenyl substituents.

Published
2008
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