Search

Your search keyword '"Madsen EC"' showing total 1 results
Start Over Author "Madsen EC" Topic amides

Refine your results

1 results on '"Madsen EC"'

1. Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides.

Author

Toth JL, Price CA, Madsen EC, Handl HL, Hudson SJ, Hubbard RB 3rd, Bowen JP, Kiakos K, Hartley JA, and Lee M

Subjects
Alkylation, Amides chemistry, Base Sequence, Benzofurans chemistry, Binding Sites, Molecular Conformation, Substrate Specificity, Amides metabolism, Benzofurans metabolism, DNA genetics, DNA metabolism, Imidazoles chemistry, Pyrroles chemistry
Abstract

Conjugates of racemic seco-cyclopropaneindoline-2-benzofurancarboxamide (CI-Bf) and four diamides (ImIm 1, ImPy 2, PyIm 3, and PyPy 4, where Py is pyrrole, and Im is imidazole), linked by a gamma-aminobutyrate group were synthesized. In addition to alkylating at adenine-N3 positions within an A(5) sequence, the imidazole-containing compounds 1 and 2 were found to also alkylate purine-N3 positions within a sequence 3'-GGGGGGA(888)CTGCTC(894)-5'. A model for the binding of hairpin conjugates 1 and 2 with the 3'-GACT-5' sequence is proposed.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results